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Exponential rise in COVID-19 hospitalization risk with age due to waning T cell immunity

The age-related increase in the risk of severe disease and death from COVID-19 mirrors earlier patterns seen with infections. Such trends may help understand the mechanisms underlying the clinical feature. A recent study published in the preprint server medRxiv* in August 2020 shows the effect of age and sex on COVID-19 hospitalization rates in the USA and helps understand how immune function is involved in this pandemic.

2 Sep 2020

Researchers report a liquid biopsy for COVID-19

A new study published on the preprint server medRxiv in July 2020 reports the potential of cell-free DNA as a marker of the severity of disease in COVID-19. This could help triage patients as well as provide a prognostic marker.

30 Jul 2020

Anti-inflammatory medication helps fight dangerous immune response in COVID-19 patients

Most patients hospitalized with COVID-19 (coronavirus) pneumonia experienced improvement after receiving a Food and Drug Administration-approved drug normally given for rheumatoid arthritis, according to an observational study at Cedars-Sinai.

15 Jul 2020

Producing CAR T cell therapy at a lower cost

Chimeric antigen receptor (CAR) T cell therapy is a new and in some cases highly effective form of immunotherapy to treat certain types of cancer of the blood and lymph system.

23 Jun 2020

Researchers call for caution of using CAR-T immunotherapy against AML

Acute myeloid leukemia is a hematological malignancy which incidence increases with age, that is biologically, phenotypically, and genetically very heterogeneous.

17 Jun 2020

New method to control inflammatory response induced by COVID-19

Severe COVID-19 illness can result in excessive inflammation throughout the body, including the lungs, heart and brain. University of Minnesota Twin Cities student Molly Gilligan recently published an article in the journal Cancer & Metastasis Reviews that studied the human body's robust inflammatory response to the SARS-CoV-2 virus, which is now recognized as a hallmark symptom.

13 May 2020

Study unravels mechanisms responsible for postnatal skin expansion

In adult tissue, the number of cells in each tissues and organs remains constant, and any new cells produced by cell division need to be compensated by the loss of other cells.

29 Apr 2020

Study marks a major step towards beta cell replacement therapy

The loss of insulin-secreting beta cells by autoimmune destruction leads to type 1 diabetes. Clinical islet cell transplantation has the potential to cure diabetes, but donor pancreases are rare.

28 Apr 2020

Study shows how tumor cells respond to lack of nutrients

Some solid tumors have a very high growth rate, which often leads to a lack of vascularization due to the impossibility to develop, at the same time, the blood vessels that accompany and nourish it.

21 Apr 2020

'Living drug factories' could be used to achieve long-term treatment of chronic diseases

One promising way to treat diabetes is with transplanted islet cells that produce insulin when blood sugar levels get too low.

30 Mar 2020

New method to treat blindness using retinal cell production

Scientists in Sweden have innovated a method of treating blindness using embryonic stem cells to produce retinal cells.

30 Mar 2020

Researchers reveal new vulnerability in MYC-driven lymphomas

Walter and Eliza Hall Institute researchers have revealed a new vulnerability in lymphomas that are driven by one of the most common cancer-causing changes in cells.

20 Feb 2020

Breakthrough discovery could open up new treatments for some blood cancers

Reversing runaway inflammation in the bone marrow could lead to major breakthroughs in treatments for some blood cancers, according to a new publication by scientists at Hackensack Meridian Health's Center for Discovery and Innovation.

16 Feb 2020

Growing eggs and sperm to treat infertility

Scientists at the University of California, Los Angeles, have reported, in the journal Cell Reports, the mechanism of how the very early precursor or stem cells which eventually give rise to the germ cells, eggs and sperm, are formed over the course of development. This could help create eggs and sperms under laboratory conditions to help infertile people who don’t have sperms, or eggs, for instance.

9 Feb 2020

Researchers reveal mutation's role in blood cancers

A genetic mutation that disrupts how DNA sends messages to the rest of a cell has been linked to a large number of blood cancers.

3 Feb 2020

Bone marrow chip provides new strategy for understanding Shwachman-Diamond syndrome

A new research tool that mimics the behavior of diseased bone marrow provides a new strategy for understanding the bone marrow disease, Shwachman-Diamond syndrome, and hopefully, developing new treatments.

28 Jan 2020

Scientists develop 3D atlas of bone marrow to help study blood diseases

The bone marrow, which is the spongy and viscous tissue that fills the bone, is the site of blood cell formation or hematopoiesis. If the bone marrow doesn’t work properly, it can lead to many blood diseases, including leukemia, sickle cell anemia, and lymphoma, among others.

23 Dec 2019