Central Nervous System News and Research

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Osimertinib plus chemotherapy shows significant PFS benefit in advanced EGFR-mutated NSCLC

Osimertinib plus chemotherapy demonstrated a statistically significant and clinically meaningful progression-free survival benefit compared to osimertinib alone, according to research presented today at the International Association for the Study of Lung Cancer (IASLC) 2023 World Conference on Lung Cancer in Singapore.

11 Sep 2023

Adagrasib shows durable clinical activity in KRAS-G12C-mutated NSCLC

The oral, selective KRAS G12C inhibitor The oral, selective KRAS G12C inhibitor KRAS-G12C inhibitor adagrasib demonstrated durable clinical activity, with a median overall survival of 14.1 months and approximately one in three patients alive at two years, according to research presented today at the International Association for the Study of Lung Cancer (IASLC) 2023 World Conference on Lung Cancer in Singapore.

11 Sep 2023

Senolytic therapy in mild Alzheimer’s disease shows safety in phase I trial

Researchers conducted the phase 1 trial of orally-administered senolytic therapy comprising quercetin (Q) and dasatinib (D) for symptomatic and early-stage Alzheimer's disease (AD) patients.

8 Sep 2023

Breakthrough genome-wide study uncovers new loci impacting apolipoprotein E levels and Alzheimer's risk

New genetic factors that affect the plasma apolipoprotein E levels.

8 Sep 2023

Is there an association between the COVID-19 pandemic and cancer incidence?

The COVID-19 pandemic influenced cancer incidence.

8 Sep 2023

Phase I trial of senolytic therapy shows promise in Alzheimer's disease

Alzheimer's disease is the most common cause of dementia that affects more than 6.5 million Americans, according to the Alzheimer's Association.

8 Sep 2023

Specialized astrocyte subpopulation discovery sheds light on brain health and treatment avenues

In a recent study published in Nature, researchers investigated whether glutamatergic gliotransmission was mediated by specialized astrocytes in the central nervous system.

7 Sep 2023

COVID-19 pandemic disrupted cancer diagnoses, raising alarms for future healthcare resilience

The COVID-19 pandemic led to a notable decline in new cancer diagnoses in Manitoba, Canada, particularly affecting breast, colon, and rectal cancers. The study highlights the urgent need for healthcare strategies to mitigate the impact of future disruptions on cancer detection and treatment.

6 Sep 2023

World-renowned menopause experts summarize the state of menopause knowledge and advocate for further research

In a recent review published in Cell, a group of authors delved into the complexities of menopause, assessed its global impacts on health, and evaluated the effectiveness and safety of current treatments, emphasizing the importance of further research.

6 Sep 2023

Review identifies future research directions for the study of a SARS-CoV-2 reservoir in PASC

Researchers reviewed the evidence for SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC).

6 Sep 2023

Study investigates the pathophysiological mechanisms of PASC after COVID-19

Researchers investigated early pathophysiological mechanisms potentially underlying PASC post-SARS-CoV-2 infection.

4 Sep 2023

Early life high fructose exposure is associated with increased prevalence of adolescent anxiety disorders

Researchers investigated whether exposure to high fructose in early life directly affects essential microglia function.

4 Sep 2023

Scientists discover new microglial population important for memory and learning

Following more than seven years of research, researchers at the University of Seville-IBiS (Institute of Biomedicine of Seville) have identified a new key cell type with a critical role in the developmental processes of memory and learning.

31 Aug 2023

Ciliopathies: A new understanding of the role of the NSL complex

The non-specific lethal (NSL) complex is a chromatin-associated factor that has been shown to regulate the expression of thousands of genes in both fruit flies and mammals.

25 Aug 2023

Study shows that CD98hc can be targeted to deliver biotherapeutics in brain

Researchers engineered and characterized a blood-brain barrier transport vehicle targeting the CD98 heavy chain of heterodimeric amino acid transporters.

24 Aug 2023

Study finds examining retinal structure could provide markers for Parkinson disease

A new paper examined the retinal data from Parkinson disease patients in attempt to identify disease markers.

24 Aug 2023

Associations between cardiorespiratory fitness in young men and the incidence of site-specific cancer

A recent study assessed the association between cardiorespiratory fitness and some cancers in healthy young men.

21 Aug 2023

Lorazepam linked to shorter progression-free survival in pancreatic cancer patients

Patients with pancreatic cancer who took the benzodiazepine lorazepam (Ativan), commonly prescribed to treat anxiety during cancer treatment, had a shorter progression-free survival than patients who did not, according to results published in Clinical Cancer Research, a journal of the American Association for Cancer Research (AACR).

17 Aug 2023

Sulfate groups on complex sugar molecules affect brain plasticity

Can you recognize someone you haven't seen in years, but forget what you had for breakfast yesterday? Our brains constantly rearrange their circuitry to remember familiar faces or learn new skills, but the molecular basis of this process isn't well understood.

16 Aug 2023

Study shows how brain rhythms can affect brain function by altering microglia and cytokines

Researchers used visual flickering sensory stimulation to reveal the underlying mechanisms governing microglial morphology and cytokine expression in mice.

16 Aug 2023

Central Nervous System News and Research

Osimertinib plus chemotherapy shows significant PFS benefit in advanced EGFR-mutated NSCLC

Adagrasib shows durable clinical activity in KRAS-G12C-mutated NSCLC

Senolytic therapy in mild Alzheimer’s disease shows safety in phase I trial

Breakthrough genome-wide study uncovers new loci impacting apolipoprotein E levels and Alzheimer's risk

Is there an association between the COVID-19 pandemic and cancer incidence?

Phase I trial of senolytic therapy shows promise in Alzheimer's disease

Specialized astrocyte subpopulation discovery sheds light on brain health and treatment avenues

COVID-19 pandemic disrupted cancer diagnoses, raising alarms for future healthcare resilience

World-renowned menopause experts summarize the state of menopause knowledge and advocate for further research

Review identifies future research directions for the study of a SARS-CoV-2 reservoir in PASC

Study investigates the pathophysiological mechanisms of PASC after COVID-19

Early life high fructose exposure is associated with increased prevalence of adolescent anxiety disorders

Scientists discover new microglial population important for memory and learning

Ciliopathies: A new understanding of the role of the NSL complex

Study shows that CD98hc can be targeted to deliver biotherapeutics in brain

Study finds examining retinal structure could provide markers for Parkinson disease

Associations between cardiorespiratory fitness in young men and the incidence of site-specific cancer

Lorazepam linked to shorter progression-free survival in pancreatic cancer patients

Sulfate groups on complex sugar molecules affect brain plasticity

Study shows how brain rhythms can affect brain function by altering microglia and cytokines

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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