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Gene mutations may explain the poorer outcomes in Hispanic and Latino children with leukemia

A combination of genetic mutations may explain the higher incidence of and poorer outcomes from pediatric leukemia in Hispanic and Latino children, according to Penn State College of Medicine researchers.

2 Feb 2021

New method identifies important mutations behind hereditary non-polyposis colorectal cancer

Colorectal cancer is the third most common form of cancer. While 90% of cases are in people older than 50, there is an as-yet unexplained rising incidence in younger people.

29 Jan 2021

Common anticoagulant drug could be repurposed to help alleviate Covid-19 infections

An international team of researchers led by the Universities of Keele and Liverpool, working with Public Health England, has found that the common anticoagulant drug heparin inhibits the SARS-Cov2virus spike protein, by reducing the virus' ability to attach to human cells and infect them.

28 Jan 2021

New method can help identify potential anti-cancer drugs at a high pace

The enzymes in human cells known as histone deacetylases, or HDACs, are targets for a handful of anticancer drugs because of their ability to affect gene expression.

25 Jan 2021

Second-generation double antibody protects from SARS-CoV-2 and its tested variants

The Institute for Research in Biomedicine (IRB; Bellinzona, Switzerland), affiliated to the Università della Svizzera italiana (USI) developed a second-generation 'double antibody' that protects from SARS-CoV-2, the virus causing COVID-19, and all its tested variants. It also prevents the virus from mutating to resist the therapy.

24 Jan 2021

A single genetic test can identify the presence and cause of mismatch repair deficiency

Researchers have developed a new integrated genetic/epigenetic DNA-sequencing protocol known as MultiMMR that can identify the presence and cause of mismatch repair (MMR) deficiency in a single test from a small sample of DNA in colon, endometrial, and other cancers.

21 Jan 2021

COVID-19 has transformed the world of vaccines

Researchers at GlaxoSmithKline (GSK) in Italy and Belgium say the coronavirus disease 2019 (COVID-19) pandemic is transforming the world of vaccinology by accelerating vaccine development and the availability of powerful technologies.

20 Jan 2021

Researchers develop FLASH ultra-high-dose rate radiation therapy beam for cancer treatment

A joint team of researchers from Radiation Oncology at Dartmouth's and Dartmouth-Hitchcock's Norris Cotton Cancer Center, Dartmouth Engineering, and Dartmouth-Hitchcock's Department of Surgery have developed a method to convert a standard linear accelerator, used for delivery of radiation therapy cancer treatment, to a FLASH ultra-high-dose rate radiation therapy beam.

19 Jan 2021

Australian scientists develop a new method for rapid synthesis of safe vaccines

With COVID-19 dominating medical science and human concern, our chemists have developed a method to quickly and safely synthesize protein vaccines for respiratory diseases for pre-clinical tests.

18 Jan 2021

MVA SARS-CoV-2 vaccine candidate shows strong immunogenicity in preclinical trials

A new study reports the preclinical testing of a recombinant MVA (rMVA) candidate vaccine against SARS-CoV-2, the agent that is causing the current COVID-19 pandemic.

14 Jan 2021

Engineered nanodroplets and ultrasound 'drill' can help eliminate tough blood clots

Engineering researchers have developed a new technique for eliminating particularly tough blood clots, using engineered nanodroplets and an ultrasound "drill" to break up the clots from the inside out.

7 Jan 2021

FDA takes first steps in bringing clarity to emerging area of individualized drug development

Advances in scientific knowledge and drug development technology have provided an opportunity for new approaches to drug development, including the development of drugs for the treatment of rare diseases.

4 Jan 2021

Kobe University and Sysmex conduct joint research on ELISPOT method for identifying COVID-19

Kobe University and Sysmex Corporation have been engaged in joint research on the ELISPOT method, a new blood test for identifying the novel coronavirus disease (COVID-19).

24 Dec 2020

Study paves the way to a potential new treatment for rare terminal childhood illness

Scientists at the University of Exeter have identified a way to "rescue" cells that have genetically mutated, paving the way to a possible new treatment for rare terminal childhood illness such as mitochondrial disease.

18 Dec 2020

Ohio State receives $10 million gift to establish new myeloma research center

The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute has received a $10 million gift from the Paula and Rodger Riney Foundation to establish the Riney Family Foundation Myeloma Center for Advanced Research Excellence.

17 Dec 2020

BAT advances COVID-19 vaccine candidate into phase-I clinical trial

The COVID-19 vaccine candidate (KBP-COVID-19; NCT04473690) will become one of a number of potential vaccines to have progressed beyond pre-clinical testing.

16 Dec 2020

Could wastewater surveillance help track SARS-COV-2 community outbreaks?

A team of US-based researchers recently conducted an illuminating study that explores this method and its potential uses. In doing so, they have underscored the potential utility of wastewater surveillance in managing SARS-CoV-2 outbreaks.

15 Dec 2020

Wastewater testing can detect COVID-19 cases weeks before people show clinical signs

A new study from Australia’s national science agency, CSIRO, and the University of Queensland provides further evidence that wastewater (untreated sewage) testing can detect COVID-19 in communities weeks before people display symptoms, suggesting this testing could provide a targeted early detection system as economies re-open and people become more mobile.

14 Dec 2020

Virginia Tech researchers awarded NIH grant to develop Zika virus vaccine

Flaviviruses -- a group of viruses transmitted by ticks or mosquitoes -- infect an estimated 400 million people annually with diseases like yellow fever, Dengue fever, West Nile virus, and, most recently, Zika virus.

9 Dec 2020

Nanomedicine's giant step into the fight against the COVID-19

A recent editorial in Nature Nanotechnology discusses the enormous feat of scientific innovation, with messenger RNA (mRNA)-based vaccines developed to deliver the gene sequence of specific SARS-CoV-2 viral proteins into host cells using nanotechnology platforms.

1 Dec 2020