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Exploring evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates

Researchers performed high-throughput evolutionary analyses of genes encoding 334 SARS-CoV-2 viral-interacting proteins of modern humans, primates, and bats.

11 Apr 2022

The emergence and limited spread of the Mu SARS-CoV-2 variant

A recent report provides insights into the restricted worldwide spread of the SARS-CoV-2 Mu (B.1.621) variant.

4 Apr 2022

MERS-CoV-related viruses invade host cells via bat angiotensin-converting enzyme 2 receptors

A recent study discovered that near relatives of MERS-CoV utilize ACE2 as functional receptors.

31 Mar 2022

Newcastle disease virus-based trivalent vaccine found to be effective across SARS-CoV-2 variants in mice

In a new study, researchers tested the bi-, tri-, and tetravalent formulations of Newcastle disease virus (NDV)-based low-cost vaccine in mice.

29 Mar 2022

Study evaluates mutation-induced SARS-CoV-2 spike protein fold stability

Researchers evaluated the stability and expression of mutations in the spike protein of SARS-CoV-2.

24 Mar 2022

Study evaluates interactions between SARS-CoV-2 proteins and viral and host RNA

A new study investigated the interactions between SARS-CoV-2 proteins and viral and host ribonucleic acid in virus-infected cells.

22 Mar 2022

Origins and evolutions of SARS-CoV-2 Alpha variant in the UK

In a new study, researchers presented the origins and evolution of the SARS-CoV-2 lineage B.1.1.7 in the United Kingdom.

10 Mar 2022

A new view of SARS-CoV-2 genome structure

Researchers performed DMS mutational profiling with sequencing and DREEM clustering to determine the SARS-CoV-2 RNA secondary structure.

8 Mar 2022

UH researchers receive grant for developing new imaging technique to peer into ribosomes

Two University of Houston researchers are developing a type of spectroscopy to help understand how ribosomes make proteins deep within cells, the discovery of which could potentially guide drug design to treat cancers and viral infections.

8 Mar 2022

Development of RT-qPCR assays for differentiating SARS-CoV-2 Omicron BA.1 and BA.2 variants

In a recent study posted to the medRxiv*preprint server, a team of researchers from Israel developed and validated novel reverse transcriptase - quantitative polymerase chain reaction (RT-qPCR) assays. The new assays enable the rapid and high throughput identification and differentiation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.1 and BA.2 variants.

8 Mar 2022

Semarion raises £2.14 million GBP ($2.89 million USD) seed funding

Investors include Parkwalk Advisors, University of Cambridge Seed Funds, Martlet Capital, and angel investors.

From Semarion 24 Feb 2022

Research shows the impact of accessory genes deletion in SARS-CoV-2 evolution

In a recent study published in the journal PLoS ONE, researchers investigated the effect of genetic variability based on accessory gene deletions on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and the clinical severity of coronavirus disease 2019 (COVID-19).

22 Feb 2022

Study confirms SARS-CoV-2 Omicron variant has a decreased ability to enter lung cells

A large multinational group of researchers has shown how the Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has gained exceptional immune evasion properties but also a much lower propensity to enter cells such as those in lung alveoli, resulting in its reduced pathogenicity. Their paper is currently released as an unedited version of the manuscript prior to publication in the journal Nature.

1 Feb 2022

Mutational analysis of SARS-CoV-2 main protease

A new study discussed the findings of a comprehensive mutational analysis of the main protease (Mpro) of SARS-CoV-2.

1 Feb 2022

Ingenza collaborates with Johnson Matthey for efficient industrial enzyme synthesis

Biotechnology company Ingenza is excited to report the successful conclusion to its recent six-month project with Johnson Matthey.

1 Feb 2022

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

The Damon Runyon Cancer Research Foundation has announced its newest cohort of Damon Runyon Fellows, 13 outstanding postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.

29 Jan 2022

Impact of clustered mutations in SARS-CoV-2 Omicron spike function

In a new study, researchers explored the characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern (VOC) Omicron BA.1 sublineage clustered mutations.

24 Jan 2022

Exploring the kinetics of SARS-CoV-2 Marseille-4 variant

In a new study, researchers determined the nature and dynamics of mutations associated with the SARS-CoV-2 French Marseille-4 variant during 10 months from its onset, and concluded that the heterogenicity associated with a SARS-CoV-2 lineage can possibly predict the end of an outbreak.

11 Jan 2022

The impact of natural selection on sequence diversity in SARS-CoV-2

Recent genomic analysis demonstrates that the SARS-CoV-2 genome is under two distinct selective forces.

3 Jan 2022

P323L mutations in SARS-CoV-2 are highly predictive of the emergence of new variants

In a new study, findings suggest that in some cases, tracking the distribution and frequency of SARS-CoV-2 minor variant genomes at a population level would help in predicting the emergence of a new dominant viral genome sequence.

30 Dec 2021

Codon News and Research

Exploring evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates

The emergence and limited spread of the Mu SARS-CoV-2 variant

MERS-CoV-related viruses invade host cells via bat angiotensin-converting enzyme 2 receptors

Newcastle disease virus-based trivalent vaccine found to be effective across SARS-CoV-2 variants in mice

Study evaluates mutation-induced SARS-CoV-2 spike protein fold stability

Study evaluates interactions between SARS-CoV-2 proteins and viral and host RNA

Origins and evolutions of SARS-CoV-2 Alpha variant in the UK

A new view of SARS-CoV-2 genome structure

UH researchers receive grant for developing new imaging technique to peer into ribosomes

Development of RT-qPCR assays for differentiating SARS-CoV-2 Omicron BA.1 and BA.2 variants

Semarion raises £2.14 million GBP ($2.89 million USD) seed funding

Research shows the impact of accessory genes deletion in SARS-CoV-2 evolution

Study confirms SARS-CoV-2 Omicron variant has a decreased ability to enter lung cells

Mutational analysis of SARS-CoV-2 main protease

Ingenza collaborates with Johnson Matthey for efficient industrial enzyme synthesis

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

Impact of clustered mutations in SARS-CoV-2 Omicron spike function

Exploring the kinetics of SARS-CoV-2 Marseille-4 variant

The impact of natural selection on sequence diversity in SARS-CoV-2

P323L mutations in SARS-CoV-2 are highly predictive of the emergence of new variants

Innovations in baculovirus–insect cell expression systems

Compound Management and its Crucial Role in Early Pharmaceutical Research

Natural products: the next frontier in drug discovery

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