Computational Modeling News and Research

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Collaborations and co-achievements of network of COST Actions on COVID-19

Addressing societal issues by enabling cross-disciplinary partnerships is an inherent part of a COST Actions' nature. But collaborations don't stop at the gate of these specific networks: multiple COST Actions have joined forces since the beginning of the pandemic to help advance research into COVID-19.

20 Oct 2021

Using AI in biology to unravel how cells fight off invaders

Imagine the day when any tissue or organ can be repaired or the replacements personalized to the patient.

7 Oct 2021

Patient-specific whole-heart computational models provide insights for personalized treatment

Whole-heart ventricular modeling has come a long way in recent years and is currently witnessing the evolution of a variety of computational approaches, especially within the realm of personalized technologies for patient-specific clinical applications.

29 Sep 2021

Decreased synaptic gain in people diagnosed with schizophrenia

Schizophrenia, which can cause disrupted thought and mood, delusions and hallucinations, is among the most debilitating mental disorders and the most mysterious.

23 Sep 2021

Characterizing the flexibility of SARS-CoV-2 variant of concern spike proteins

A novel protein modeling method assesses changes to the conformation of the SARS-CoV-2 spike protein that have been encountered by mutation.

19 Sep 2021

Washington University School of Medicine receives $7 million to investigate how human genome works

Washington University School of Medicine in St. Louis has received a $7 million grant from the National Institutes of Health to help lead national efforts to investigate how variations in the human genome sequence affect how the genome functions.

9 Sep 2021

IGVF consortium receives NIH funding to study how genomic variation influences biological function

The National Institutes of Health is providing approximately $185 million over five years to the Impact of Genomic Variation on Function consortium, initiated and funded by NIH's National Human Genome Research Institute.

9 Sep 2021

Study uses computational modeling of coronavirus spike proteins to examine dynamics responsible for immunogenicity and immune escape

A new study published on the bioRxiv* preprint server focused on the development of dynamic computational models for a large subset of S proteins of SARS-CoV, MERS-CoV, and SARS-CoV-2.

23 Aug 2021

SARS-CoV-2 lambda variant escapes immune response via spike mutations

A new study explores the mechanism by which the SARS-CoV-2 lambda variant has acquired immune evasion capabilities above that of the wildtype.

20 Aug 2021

Study offers molecular views on how olfactory receptors work

All senses must reckon with the richness of the world, but nothing matches the challenge faced by the olfactory system that underlies our sense of smell.

4 Aug 2021

Improvements in neural learning processes linked to reduced symptoms of depression

Virginia Tech scientists with the Fralin Biomedical Research Institute at VTC have identified neural learning processes to be associated with symptoms of depression and linked improvements in these processes to improved symptoms in research participants being treated for depression.

28 Jul 2021

Study assesses the impact of tic suppression on brain functional connectivity in Tourette syndrome

Tourette syndrome, a neurodevelopmental disorder, causes motor and phonic "tics" or uncontrollable repeated behaviors and vocalizations. People affected by Tourette syndrome can often suppress these tics for some time before the urges become overwhelming, and researchers have long wondered at the neural underpinnings of the suppression effort.

7 Jul 2021

Varenicline blocks SARS-CoV-2 infection in cells and animal models

A new paper released on the bioRxiv* preprint server suggests that the nicotinic acetylcholine receptor (nACHR) agonist, varenicline tartrate, has antiviral activity against the virus.

5 Jul 2021

New model identifies effective dissemination strategies for Type 2 diabetes guidelines

Health care workers often don't adopt new guidelines for best practices in medical care until well after those guidelines are established.

17 Jun 2021

Sophisticated brain models can predict language recovery in Hispanic stroke survivors

At Boston University, a team of researchers is working to better understand how language and speech is processed in the brain, and how to best rehabilitate people who have lost their ability to communicate due to brain damage caused by a stroke, trauma, or another type of brain injury.

7 Jun 2021

New study undermines the link between neural electrical activity and free will

For decades, researchers have debated whether the buildup of certain electrical activities in the brain indicates that human beings are unable to act out of free will.

4 Jun 2021

Hydroxychloroquine + Azithromycin therapy at a higher dose improved survival by nearly 200% in ventilated COVID patients

However, a fascinating new study posted to the medRxiv* preprint server suggests that such disappointment may have been both premature and unwarranted, based on a re-analysis of over 250 patients on invasive mechanical ventilation (IMV) during the first two months of the pandemic.

2 Jun 2021

Could GRP78 be a therapeutic target against COVID-19?

A new study by a team of researchers at the Keck School of Medicine, University of Southern California, USA, reports a potentially important therapeutic target in the form of a molecule called GRP78 that promotes the entry and protein production by many viruses. The team's paper has been published in the Journal of Biological Chemistry.

26 May 2021

Novel natural compounds may help treat COVID-19, study suggests

A new study in the journal Chemistry Europe reports two natural compounds identified by virtual screening and computational modeling as having great promise for the development of drugs against SARS-CoV-2.

24 May 2021

Virtual analysis identifies a potential natural inhibitor of SARS-CoV-2 Nsp15

A new paper reports the discovery of promising antiviral hit compounds through the use of computational modeling studies on natural compounds.

19 May 2021