Convalescent Plasma News and Research

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Impeding SARS‑CoV‑2 evolution by targeting low-probability stochastic events

Researchers explore the emergence of more fit SARS-CoV-2 variants using a stochastic evolutionary modeling framework during long-term infections.

24 Nov 2021

Similar antibody responses to spike protein in COVID-19 survivors and vaccine recipients

Researchers conducted a study on COVID-19 convalescent patients and post-vaccinated populations to identify the minimal levels of antibody required to protect against SARS-CoV-2 infection.

24 Nov 2021

Comparing effectiveness of virus and patients-centered strategies to reduce COVID-19 mortality

Researchers from Sorbonne Université have been reviewing papers exploring different anti-COVID-19 drugs.

19 Nov 2021

Rapid finger stick test to detect antibodies against SARS-CoV-2 variants

A new preprint reports a semi-quantitative test that can measure neutralizing antibodies to the SARS-CoV-2 pathogen at the point of care, using a finger stick or venipuncture blood.

16 Nov 2021

Analysis of immunodeficient patients granted REGEN-COV under compassionate use COVID-19 program

A team of scientists describe the safety and response to REGEN-COV® for COVID-19 patients with immunodeficiency-associated antibody disorders.

11 Nov 2021

The SARS-CoV-2 Beta variant evades Fc effector function by ancestral strain, study says

A new study finds improved Fc cross-reactivity against certain SARS-CoV-2 variant of concern.

10 Nov 2021

Convalescent plasma post-vaccination increases binding and neutralizing antibodies against SARS-CoV-2 variants

A recent study assesses the boost in antibodies against SARS-CoV-2)variants post-vaccination in plasma samples from previously infected COVID-19 patients.

7 Nov 2021

Antibody response of COVID-19 patients to SARS-CoV-2 and seasonal coronaviruses

Scientists conducted a cohort study and measured the prevalence and the levels of antibody responses to the nucleocapsid protein of SARS-CoV-2 and four seasonal human coronaviruses.

3 Nov 2021

SARS-CoV-2 neutralizing antibodies discovered in a 20-year-old human antibody library

In an article published in the open-access journal Advance Engineering, a multinational team of researchers reported the selection and characterization of 3 potent SARS-CoV-2 antibodies - S-E6, S-B8, and S-D4 - from a pre-COVID-19 human combinatorial antibody library that was established 20 years ago.

3 Nov 2021

Isolation of potent neutralizing monoclonal antibodies using nanoparticles displaying SARS-CoV-2 S glycoprotein

A new study aimed to identify several potent neutralizing RBD-directed and NTD-directed mAbs that used a nanoparticle displaying the S glycoprotein to capture SARS-CoV-2-specific B cells.

2 Nov 2021

SARS-CoV-2 variants neutralized by camel nanobodies

Researchers from the US recently isolated two VHH nanobodies - 7A3 and 8A2 - from dromedary camels (Camelus dromedaries) using phage display. These nanobodies were found to have a high affinity for the spike RBD and broad neutralization abilities against SARS-CoV-2 and its variants.

2 Nov 2021

Evidence antibodies targeting HCoV-OC43 are robustly boosted in response to SARS-CoV-2 but not vaccination

The magnitude of cross-reactive antibodies correlated well with responses to the SARS-CoV-2 spike protein and the S2 subdomain.

1 Nov 2021

Emerging SARS-CoV-2 variant A.30 efficiently evades vaccine-induced immunity

A recent study published in the journal Cellular & Molecular Immunology shows that a new A.30 variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can evade vaccine-induced antibodies and might spread outside the lungs extraordinarily well, with important implications for our public health response.

1 Nov 2021

New Canadian serology solution for SARS-CoV-2 infections and vaccination

A new study developed a “Made-in-Canada” solution for enabling scalable and reproducible SARS-CoV-2 serology.

31 Oct 2021

SARS-CoV-2 cocktail with three antibodies potent in preclinical testing

Amidst growing concerns on the use and potential benefits of convalescent plasma therapy, a research group in the United States has identified three human antibodies (Abs) that, when combined, demonstrate both robust viral suppressive properties against all tested severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Variants of Concern (VoC) in vitro and profound antiviral efficacy in vivo.

22 Oct 2021

Serologic testing algorithm to detect disparities in SARS-CoV-2 infection prevalence and vaccination uptake

A new study recently published on the medRxiv* preprint server demonstrates the use of a serological testing algorithm for identifying disparities in infection rates and vaccine uptake amongst the study population to enable public health interventions.

17 Oct 2021

Convalescent Plasma News and Research

Impeding SARS‑CoV‑2 evolution by targeting low-probability stochastic events

Similar antibody responses to spike protein in COVID-19 survivors and vaccine recipients

Comparing effectiveness of virus and patients-centered strategies to reduce COVID-19 mortality

Rapid finger stick test to detect antibodies against SARS-CoV-2 variants

Analysis of immunodeficient patients granted REGEN-COV under compassionate use COVID-19 program

The SARS-CoV-2 Beta variant evades Fc effector function by ancestral strain, study says

Convalescent plasma post-vaccination increases binding and neutralizing antibodies against SARS-CoV-2 variants

Antibody response of COVID-19 patients to SARS-CoV-2 and seasonal coronaviruses

SARS-CoV-2 neutralizing antibodies discovered in a 20-year-old human antibody library

Isolation of potent neutralizing monoclonal antibodies using nanoparticles displaying SARS-CoV-2 S glycoprotein

SARS-CoV-2 variants neutralized by camel nanobodies

Evidence antibodies targeting HCoV-OC43 are robustly boosted in response to SARS-CoV-2 but not vaccination

Emerging SARS-CoV-2 variant A.30 efficiently evades vaccine-induced immunity

New Canadian serology solution for SARS-CoV-2 infections and vaccination

SARS-CoV-2 cocktail with three antibodies potent in preclinical testing

Serologic testing algorithm to detect disparities in SARS-CoV-2 infection prevalence and vaccination uptake

Ondansetron use associated with increased survival in mechanically ventilated COVID-19 patients

Accumulation of SARS-CoV-2 mutations reduces sensitivity to neutralizing antibodies

Powerful neutralizing antibody against SARS-CoV-2 variants of concern

Adapting biological research and development to COVID-19

Michael Stryker

The past, present and future of automation and digitalization in the life sciences laboratory

Arxspan BioDrive: A Versatile Solution for Molecular Biology

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