Cryptorchidism News and Research

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Do environmental and occupational factors influence semen quality?

New research sheds light on how environmental and occupational factors impact male fertility, revealing that proximity to power lines may enhance semen quality while living near chemical factories could be detrimental. The study emphasizes the need for a deeper understanding of these factors in the context of rising infertility rates.

25 Sep 2023

Spasticity in the lower extremities linked to higher odds of cryptorchidism in boys with cerebral palsy

Cerebral Palsy has been linked to a condition called cryptorchidism in males-;when one or both of the testicles are not present in the scrotum.

7 Jun 2023

Study contributes to better understanding of rare KAT6A syndrome

A research team has described five new cases of a rare disease -known as KAT6A syndrome- of which there are only eighty dominant cases worldwide.

26 Feb 2020

Boys born small at higher risk of infertility

A new study published in the journal Human Reproduction on December 13, 2019, shows that baby boys who don’t grow as well as expected in the womb may grow up to be infertile as adults. The study showed a 55% or 85% higher risk of infertility among this group of men compared to those born with appropriate weights.

15 Dec 2019

IBR receives $1.95 million NIH grant for research on rare diseases

The New York State Office for People With Developmental Disabilities' Institute for Basic Research in Developmental Disabilities has received a $1.95 million grant, for a five-year period, from the National Institute of Health's National Institute of General Medical Sciences to support IBR physician-scientist Gholson Lyon, MD, PhD, in his research on rare diseases.

5 Nov 2019

NIH researchers unravel how male, female mouse embryos acquire sex-specific reproductive systems

A protein called COUP-TFII determines whether a mouse embryo develops a male reproductive tract, according to researchers at the National Institutes of Health and their colleagues at Baylor College of Medicine, Houston.

17 Aug 2017

Scientists identify key gene in 22q11.2 that contributes to genitourinary birth defects

The 22q11.2 region of human chromosome 22 is a hotspot for a variety of birth defects. Scientists learned about this region because it is deleted in about 1 in 4,000 births, causing the loss or duplication of up to 40 genes.

25 May 2017

Scientists define genetic cause for two types of birth defects in newborn boys

Baylor College of Medicine scientists defined a previously unrecognized genetic cause for two types of birth defects found in newborn boys, described in a report published today in the journal Nature Medicine.

2 Jun 2014

Fetal exposure to BPA lowers testicular hormone in newborn boys

A new study links fetal exposure to a common chemical pollutant, bisphenol A (BPA), to defects of a testicular hormone in newborn boys with undescended testicles. The results, which were presented Monday at The Endocrine Society's 95th Annual Meeting in San Francisco, suggest yet another potential harmful effect of BPA, which is widely used in many plastics, liners of food cans and dental sealants.

18 Jun 2013

Exposure of human f-tal testicles to bisphenol A reduces testosterone production

Bisphenol A (BPA) is a chemical compound that is included in the composition of plastics and resins. It is used, for example, in the manufacture of food containers such as bottles and babies' feeding bottles. It is also found in the protective films used inside food and drink cans and on till receipts where it used as a discloser. Significant levels of BPA have also been found in human blood, urine, amniotic fluid and placentas.

23 Jan 2013

Marijuana and testicular cancer: an interview with Victoria Cortessis

This is a set of malignancies that arise in germ cells of the testicles, the specialized cells that produce sperm. Taken together, testicular cancers are the most common form of malignancy that occurs in young men (approximately 15 to 35 years of age).

24 Sep 2012

New research gains increased respect for contraceptive method

Imagine a contraceptive that could, with one or two painless 15-minute non-surgical treatments, provide months of protection from pregnancy. And imagine that the equipment needed were already in physical therapists' offices around the world.

31 Jan 2012

Using mild painkillers during pregnancy can increase risk of male reproductive disorders

New evidence has emerged that the use of mild painkillers such as paracetamol, aspirin and ibuprofen, may be part of the reason for the increase in male reproductive disorders in recent decades.

10 Nov 2010

New familial link in juvenile myelomonocytic leukemia discovered

A UCSF-led team has discovered a direct link between an inherited genetic mutation, a set of developmental abnormalities and a rare form of childhood leukemia called juvenile myelomonocytic leukemia, or JMML. The study demonstrates a new familial link in JMML and has significant implications, the researchers say, for improving the diagnosis and treatment of the disease.

9 Aug 2010

Relatives of men with cryptorchidism or hypospadias not at risk of developing testicular germ cell cancer

Boys with the sexual birth defects known as hypospadias and cryptorchidism are at risk for developing testicular germ cell cancer, but their relatives are not, according to a new study published online December 21 in the Journal of the National Cancer Institute.

22 Dec 2009

Gene therapy may hold promise for cryptorchid individuals risking infertility

EGR4 is a master gene responsible for fertility in cryptorchidism. Is gene therapy going to replace surgery?

18 Nov 2009

Exposure to stress hormones and chemicals while in the womb can affect male fertility

Exposure to a combination of excess stress hormones and chemicals while in the womb could affect a man's fertility in later life, a study suggests.

22 Oct 2009

Link found between cryptorchidism and genetic mutations

A small percentage of males born with cryptorchidism (failure of one or both testicles to descend into the scrotum), the most frequent congenital birth defect in male children, are more likely to have genetic mutations, including for a syndrome that is a common genetic cause of infertility, according to a study in the November 19 issue of JAMA .

18 Nov 2008

Healthy male reproductive organs depend on early hormone activity

A discovery by Medical Research Council scientists looking at the development of male foetuses could help explain the origin of common genital disorders that can cause reproductive problems or increase risk of low sperm counts and possibly testicular cancer later in life.

20 Mar 2008

Cryptorchidism and hypospadias

Cryptorchidism, the absence in the scrotum of one or both testes (usually because of the failure of the testis to descend), and hypospadias, the abnormal positioning of the opening of the urethra, are common birth defects of the male genitalia and are risk factors for the adult-onset disorders of low sperm count and testicular cancer.

14 Mar 2008