Cytokine News and Research

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Researchers identify new way to reduce risk of complications after joint surgery

Researchers identified a new way to lower the risk of complications after joint surgery, using a simple blood test. Patients with diabetes are more likely to need joint replacement surgery but also have a greater risk of serious complications after surgery, including heart attack, stroke, and wound infections, because of their underlying diabetes.

16 Nov 2017

Ozanimod effective against multiple sclerosis, enters New Drug Approval process with FDA

Celgene Corporation recently announced results from two phase 3 trials evaluating the efficacy and safety of the drug ozanimod.

10 Nov 2017

Scientists uncover mechanism that prevents tumor growth in melanoma

Natural Killer (NK) cells, lymphocytes of the innate immune system with strong cytotoxic activity, play a major role in the immune response against tumors.

8 Nov 2017

Gut bacteria can influence how cancer responds to immunotherapy

Bacteria that live in the human digestive tract can influence how cancer responds to immunotherapy, opening a new avenue for research to improve treatment, a team led by researchers at The University of Texas MD Anderson Cancer Center reports in the journal Science.

2 Nov 2017

Conference to focus on preventing and reversing consequences of sickle cell disease

Leading experts in the field of sickle cell disease (SCD) research will convene in Washington, D.C., for the Physiological and Pathophysiological Consequences of Sickle Cell Disease conference (November 6–8). The conference, organized by the American Physiological Society, will explore SCD- the world's most prevalent single-gene mutation disease-; and new research on preventing and reversing its deadly consequences.

1 Nov 2017

New CAR-T cell therapy offers effective option for certain blood cancer patients

Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis is one of the first centers nationwide to offer a new immunotherapy that targets certain blood cancers.

19 Oct 2017

Cascade of costs could push new gene therapy above $1 million per patient

Outrage over the high cost of cancer care has focused on skyrocketing drug prices, including the $475,000 price tag for the country's first gene therapy, Novartis' Kymriah, a leukemia treatment approved in August.

17 Oct 2017

Study provides detailed characterization of neurotoxicity arising from CD19 CAR T-cell therapy

New potential biomarkers and a novel algorithm could help identify patients at increased risk of suffering from severe neurotoxicity after receiving CD19 CAR T-cell therapy. The study extensively characterized common and occasionally fatal side effects of this immunotherapy.

12 Oct 2017

Maternal immune activation linked to ASD symptom severity in children with autism

The retrospective cohort study of 220 Australian children, conducted between 2011-2014, indicates that a "an immune-mediated subtype" of autism driven by the body's inflammatory and immunological systems may be pivotal, according to the University of Sydney's Professor Adam Guastella.

10 Oct 2017

CRISPR-Gold corrects gene mutations in mice with Duchenne muscular dystrophy

Scientists at the University of California, Berkeley, have engineered a new way to deliver CRISPR-Cas9 gene-editing technology inside cells and have demonstrated in mice that the technology can repair the mutation that causes Duchenne muscular dystrophy, a severe muscle-wasting disease.

4 Oct 2017

Scientists gain insight into how Ebola virus uses the body's defenses to speed up infection

Scientists from The University of Texas Medical Branch at Galveston have gained new insight into how the Ebola virus uses the body's natural defenses to speed the rate of infection and unleash its lethal disease, according to a new report in mBio.

26 Sep 2017

Scientists discover markers for progressive multiple sclerosis

Scientists have uncovered two closely related cytokines -- molecules involved in cell communication and movement -- that may explain why some people develop progressive multiple sclerosis (MS), the most severe form of the disease.

18 Sep 2017

Studies reveal link between autism and severe maternal infection during pregnancy

Two studies conducted at the Massachusetts Institute of Technology (MIT) and the University of Massachusetts Medical School indicated that mothers who were affected with severe infections that required hospitalization are at an increased risk of having an autistic child.

15 Sep 2017

Probiotics may become new preventative or therapeutic strategy for IBD-related colon cancer

In an innovative approach to colorectal cancer (CRC) prevention and treatment, scientists are studying ways to replace missing metabolites in patients prone to gut inflammation and CRC.

14 Sep 2017

CSHLP publishes new book on The Biology of Exercise

Cold Spring Harbor Laboratory Press today announced the release of The Biology of Exercise, available on its website in hardcover, paperback, and ebook formats.

1 Sep 2017

Study explores periodontal status of patients with Chédiak-Higashi syndrome

The International and American Associations for Dental Research have published an article titled "Periodontitis in Chédiak-Higashi Syndrome: An Altered Immunoinflammatory Response" in the JDR Clinical & Translational Research.

31 Aug 2017

FDA makes the first gene therapy Kymriah available for treatment of pediatric ALL

The U.S. Food and Drug Administration (FDA) has issued a press release making the first even gene therapy available for treatment of children with a form of acute lymphoblastic leukemia (ALL).

30 Aug 2017

$Novartis gets FDA approval for novel immunocellular therapy to treat relapsed or refractory B-cell ALL$

Novartis gets FDA approval for novel immunocellular therapy to treat relapsed or refractory B-cell ALL

Novartis announced today that the US Food and Drug Administration has approved Kymriah (tisagenlecleucel) suspension for intravenous infusion, formerly CTL019, the first chimeric antigen receptor T cell (CAR-T) therapy, for the treatment of patients up to 25 years of age with B-cell precursor acute lymphoblastic leukemia (ALL) that is refractory or in second or later relapse.

30 Aug 2017

FDA approves first cell-based gene therapy for use in the United States

The U.S. Food and Drug Administration issued a historic action today making the first gene therapy available in the United States, ushering in a new approach to the treatment of cancer and other serious and life-threatening diseases.

30 Aug 2017

Anti-inflammatory therapy reduces incidence of lung cancer

In most clinical trials for cancer therapy, investigators test treatments in patients with advanced disease. But a recent cardiovascular secondary prevention study has given researchers a unique opportunity: to explore the effectiveness of giving a drug to patients before cancer emerges.

28 Aug 2017

Cytokine News and Research

Researchers identify new way to reduce risk of complications after joint surgery

Ozanimod effective against multiple sclerosis, enters New Drug Approval process with FDA

Scientists uncover mechanism that prevents tumor growth in melanoma

Gut bacteria can influence how cancer responds to immunotherapy

Conference to focus on preventing and reversing consequences of sickle cell disease

New CAR-T cell therapy offers effective option for certain blood cancer patients

Cascade of costs could push new gene therapy above $1 million per patient

Study provides detailed characterization of neurotoxicity arising from CD19 CAR T-cell therapy

Maternal immune activation linked to ASD symptom severity in children with autism

CRISPR-Gold corrects gene mutations in mice with Duchenne muscular dystrophy

Scientists gain insight into how Ebola virus uses the body's defenses to speed up infection

Scientists discover markers for progressive multiple sclerosis

Studies reveal link between autism and severe maternal infection during pregnancy

Probiotics may become new preventative or therapeutic strategy for IBD-related colon cancer

CSHLP publishes new book on The Biology of Exercise

Study explores periodontal status of patients with Chédiak-Higashi syndrome

FDA makes the first gene therapy Kymriah available for treatment of pediatric ALL

Novartis gets FDA approval for novel immunocellular therapy to treat relapsed or refractory B-cell ALL

FDA approves first cell-based gene therapy for use in the United States

Anti-inflammatory therapy reduces incidence of lung cancer

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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