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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

FGFR1 amplification heralds poor prognosis in SCCL

Amplification of the fibroblast growth factor receptor 1 gene independently predicts poor outcomes in patients who have undergone resection of squamous cell lung cancer, research shows.

10 Dec 2012

Microarray analysis ‘best test for prenatal diagnosis’

Chromosomal microarray analysis is able to identify significantly more clinically relevant information for prenatal diagnosis than is karyotyping, and is equally able to highlight aneuploidies and unbalanced rearrangements, US study findings suggest.

10 Dec 2012

New study could help develop anti-inflammatory drugs with fewer side effects

10 Dec 2012

Angiocidin reduces acute myeloid leukemia cells in vivo by almost two-thirds in pre-clinical studies

Angiocidin, a novel tumor-inhibiting protein, has been shown to reduce acute myeloid leukemia (AML) cells in vivo by almost two-thirds in pre-clinical experiments.

10 Dec 2012

Researchers track emergence and global spread of healthcare-associated C. difficile

Researchers show that the global epidemic of Clostridium difficile 027/NAP1/BI in the early to mid-2000s was caused by the spread of two different but highly related strains of the bacterium rather than one as was previously thought. The spread and persistence of both epidemics were driven by the acquisition of resistance to a frontline antibiotic.

10 Dec 2012

Targeting RAD52 protein can block the process by which leukemia stem cells repair themselves

Despite treatment with imatinib, a successful drug that targets chronic myeloid leukemia (CML), a deadly type of cancer, some patients may continue to be at risk for relapse because a tiny pool of stem cells is resistant to treatment and may even accumulate additional genetic aberrations, eventually leading to disease progression and relapse. These leukemia stem cells are full of genetic errors, loaded with potentially lethal breaks in DNA, and are in a state of constant self-repair.

10 Dec 2012

Most triple-negative breast cancer patients have multiple genetic mutations after chemo treatment

Most triple-negative breast cancer patients who were treated with chemotherapy to shrink the tumor prior to surgery still had multiple genetic mutations in their tumor cells, according to a study by Vanderbilt-Ingram Cancer Center (VICC) investigators.

10 Dec 2012

Novel sensor measures individual particles in blood samples

Norwegian researchers have developed the world's first sensor capable of measuring individual particles in a blood sample. This new innovation could cause a sensation in the medical world.

7 Dec 2012

Noncoding DNA sequence required for epidermal differentiation

The differentiation of human epidermis is controlled and stabilized by a long noncoding RNA termed terminal differentiation-induced noncoding RNA acting through a post-transcriptional mechanism, the results of an innovative US study indicate.

7 Dec 2012

Novel organic metamaterial holds promise for drug delivery

A bit reminiscent of the Terminator T-1000, a new material created by Cornell researchers is so soft that it can flow like a liquid and then, strangely, return to its original shape.

7 Dec 2012

Study identifies epigenetic events critical to cancer cell survival

USC Norris Comprehensive Cancer Center research that identifies specific genes that have to be turned off in order for cancer cells to survive was named one of the top major advances in cancer research this year by the American Society of Clinical Oncology (ASCO).

7 Dec 2012

Disturbances in several immune-system-related pathways contribute to development of ASDs

Researchers using novel approaches and methodologies of identifying genes that contribute to the development of autism have found evidence that disturbances in several immune-system-related pathways contribute to development of autism spectrum disorders.

7 Dec 2012

New genetic process could provide novel target for treatment of neurodevelopmental disorders

Researchers at the Douglas Mental Health University Institute, have discovered a new genetic process that could one day provide a novel target for the treatment of neurodevelopmental disorders, such as intellectual disability and autism.

7 Dec 2012

Microarray technology provides comprehensive result during prenatal care of women

A new method for detecting abnormalities in unborn children is providing physicians with more information to analyze the results than conventional, microscopic testing, according to two George Washington University researchers.

7 Dec 2012

Study finds relationships between body size and epigenetic changes

New research in human volunteers has shown that molecular changes to our genes, known as epigenetic marks, are driven mainly by ageing but are also affected by what we eat.

6 Dec 2012

Scientists identify key molecular pathway that leads to depression

Scientists have identified the key molecular pathway leading to depression, revealing potential new targets for drug discovery, according to research led by King's College London's Institute of Psychiatry. The study, published today in Neuropsychopharmacology, reveals for the first time that the 'Hedgehog pathway' regulates how stress hormones, usually elevated during depression, reduce the number of brain cells.

6 Dec 2012

Researchers unlock mechanisms of how the body converts dietary carbohydrates into fat

A gene that helps the body convert that big plate of holiday cookies you just polished off into fat could provide a new target for potential treatments for fatty liver disease, diabetes and obesity.

6 Dec 2012

Viewpoints: Lame duck Congress shouldn't take on entitlement changes; New legal challenge to health law; 'Irrational vote' on disability pact

What we need in order to address this fiscal abyss is a Grand Bargain that addresses the two main drivers of our structural deficits: unsustainable social insurance programs, especially health care programs, and a complex, unfair, uncompetitive and inadequate tax system. But a lame duck Congress cannot and should not tackle comprehensive tax and social insurance reforms.

6 Dec 2012

Study catalogs genetic variation of microbes that live in the gut

Our bodies contain far more microbial genes than human genes. And a new study suggests that just as human DNA varies from person to person, so too does the massive collection of microbial DNA in the intestine.

6 Dec 2012

Scancell announces preliminary results from Part 1 of ImmunoBody vaccine Phase 1/2 MM trial

Scancell Holdings Plc, the developer of therapeutic cancer vaccines, is pleased to announce preliminary results from Part 1 of the Phase 1/2 clinical trial of its DNA ImmunoBody vaccine in patients with Stage III/IV malignant melanoma.

6 Dec 2012

DNA News and Research

Further Reading

FGFR1 amplification heralds poor prognosis in SCCL

Microarray analysis ‘best test for prenatal diagnosis’

New study could help develop anti-inflammatory drugs with fewer side effects

Angiocidin reduces acute myeloid leukemia cells in vivo by almost two-thirds in pre-clinical studies

Researchers track emergence and global spread of healthcare-associated C. difficile

Targeting RAD52 protein can block the process by which leukemia stem cells repair themselves

Most triple-negative breast cancer patients have multiple genetic mutations after chemo treatment

Novel sensor measures individual particles in blood samples

Noncoding DNA sequence required for epidermal differentiation

Novel organic metamaterial holds promise for drug delivery

Study identifies epigenetic events critical to cancer cell survival

Disturbances in several immune-system-related pathways contribute to development of ASDs

New genetic process could provide novel target for treatment of neurodevelopmental disorders

Microarray technology provides comprehensive result during prenatal care of women

Study finds relationships between body size and epigenetic changes

Scientists identify key molecular pathway that leads to depression

Researchers unlock mechanisms of how the body converts dietary carbohydrates into fat

Viewpoints: Lame duck Congress shouldn't take on entitlement changes; New legal challenge to health law; 'Irrational vote' on disability pact

Study catalogs genetic variation of microbes that live in the gut

Scancell announces preliminary results from Part 1 of ImmunoBody vaccine Phase 1/2 MM trial

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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