DNA Damage News and Research

RSS

Researchers map the DNA damage in human lung cells after BaP exposure

People are occasionally exposed to potentially harmful substances in the environment or through their diets or habits. For example, a compound found in cigarette and industrial smoke, benzo(a)pyrene (BaP), is known to damage DNA.

22 Feb 2023

Researchers identify a novel mechanism of DNA repair that occurs in neurons

"Use it or lose it" goes the adage, applied liberally to everything from our muscles to our minds, especially as we age.

15 Feb 2023

Researchers find possible genetic basis and mouse model for nonalcoholic steatohepatitis

A mutant or damaged gene may be a cause of a severe, mysterious form of nonalcoholic fatty liver disease, University of Illinois Urbana-Champaign researchers have found.

9 Feb 2023

Protein adduction and p53 tumor suppressor inhibition

Researchers assessed the impact of protein adduction on p53 tumor suppressor inhibition.

27 Jan 2023

Scientists reveal how genetic changes lead to differences in the size of cancer cells

Cancer cells can shrink or super-size themselves to survive drug treatment or other challenges within their environment, researchers have discovered.

25 Jan 2023

Researchers discover the gene responsible for radiation resistance in mutant IDH1 glioma

It's a good news, bad news story. Patients whose brain tumors have a mutated enzyme called IDH1 typically live longer than those without the mutation.

24 Jan 2023

Study: Exposure to high doses of micro-sized polyethylene has adverse effects on cells

Exposure to high doses of micro-sized polyethylene has adverse effects on cells, a new study from the University of Eastern Finland finds.

17 Jan 2023

The loss of epigenetic information accelerates the aging process

A new study in the journal Cell aimed to determine whether epigenetic changes are a cause of mammalian aging.

15 Jan 2023

Comprehensive atlas of protein kinases could help scientists decipher many cellular signaling pathways

One of the most important classes of human enzymes are protein kinases -; signaling molecules that regulate nearly all cellular activities, including growth, cell division, and metabolism.

12 Jan 2023

Researchers discover the Nrf3-mediated mechanism of melanogenesis

The skin is presumably the largest and one of the most versatile body organs. By providing a physical barrier, it protects our body from environmental assaults.

11 Jan 2023

Anticancer drugs offer new hope for treatment of sepsis

Research led by the IGC reveals how these drugs limit inflammation, positioning them as potential treatments for sepsis.

10 Jan 2023

Sarunashi juice and its constituting component help prevent and reduce lung cancer in mice

Lung cancer is the leading cause of death in Japan and across the globe. Among all the cancers, lung cancer has one of the lowest five-year survival rates.

28 Dec 2022

Radiation damage to mature sperm cannot be repaired and is instead passed on to the offspring

Whether radiation exposure of fathers can have consequences on their children is one of the most long-standing questions in radiation biology.

21 Dec 2022

New method combines injectable radioactive gel with systemic chemotherapy to treat pancreatic cancer

Pancreatic cancer is one of the deadliest types of cancer-;in the U.S., it is estimated that over 88 percent of people will die from the disease within five years of their diagnosis.

20 Dec 2022

New combination of drugs may lead to improved treatment of cervical cancer

A new combination of drugs slowed the growth of cancer cells by an unexpected mechanism that may one day lead to improved treatment of cervical cancer, a UT Southwestern-led study published in Molecular Cancer Research suggests.

19 Dec 2022

Inhibiting inflammatory signaling pathway could reduce the chances of heart disease in cancer survivors

Researchers at Memorial Sloan Kettering Cancer Center (MSKCC) in New York have discovered that common cancer treatments, such as radiotherapy or anthracycline drugs, cause long-term damage to heart tissue by activating a key inflammatory signaling pathway.

19 Dec 2022

Severe COVID-19 causes aging-like changes in the human brain

Severe COVID-19 triggers aging-like changes in the brain's frontal cortex region that results in cognitive deficits.

11 Dec 2022

Better understanding of DNA repair mechanism may pave the way for effective cancer treatments

Better understanding of the mechanisms involved in DNA repair may pave the way for developing inhibitors to improve the effectiveness of radiation therapy.

9 Dec 2022

Study reports overall response of HER2-low breast cancer patients to neoadjuvant T-DXd treatment

Patients with localized, hormone receptor-positive, HER2-low breast cancer treated with trastuzumab deruxtecan (T-DXd, Enhertu) in the neoadjuvant setting had an overall response rate of 75 percent in the absence of anastrozole and 63 percent in combination with anastrozole, according to results from the phase II TRIO-US B-12 TALENT trial presented at the San Antonio Breast Cancer Symposium, held December 6-10, 2022.

7 Dec 2022

CRC 1361 at JGU continues to achieve excellence in DNA repair and genome stability research

The German Research Foundation (DFG) announced the prolongation of the Collaborative Research Center (CRC) 1361: "Regulation of DNA Repair and Genome Stability" for an additional four years.

2 Dec 2022