DNA Methylation News and Research

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DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. As such, it is part of the epigenetic code and is also the most well characterized epigenetic mechanism.

Analyzing DNA changes in the blood can improve prediction of type 2 diabetes risk

Analyzing changes to DNA in the blood can improve the ability to predict a person's risk of developing type 2 diabetes within a decade.

6 Apr 2023

Early life adversity linked to accelerated neurobiological aging, raising vulnerability to depression and Alzheimer's

scientists investigate the neurocognitive correlates of genetic vulnerability to major depressive disorder and Alzheimer's disease.

30 Mar 2023

Ask the Expert: 7 Questions about Colorectal Cancer & Non-invasive Fecal DNA Testing

In this interview, NewsMedical speaks with Dr. Yuying Wang, R&D Director (Oncology), from BGI Genomics, about colorectal cancer and the development and application of COLOTECT® 1.0, a non-invasive fecal DNA test for the detection of colorectal cancer and pre-cancerous lesions.

From BGI Genomics 27 Mar 2023

Age-induced methylation changes in the sperm epigenome contribute to offspring's medical problems

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 5, entitled, "Age-related methylation changes in the human sperm epigenome."

21 Mar 2023

Investigating how gut microbiota affect neuroplasticity and neurodevelopment

In a recent study published in the journal Neuropharmacology, researchers in Pisa, Italy, explored how gut microbiota can influence neuroplasticity.

20 Mar 2023

Machine learning applications for the diagnosis, treatment and prognosis of cancer

Researchers review the application of machine learning in improving cancer diagnosis, treatment, and prognosis.

19 Mar 2023

How maternal obesity and gestational diabetes can impact DNA methylation in infants

A study published in the journal Cardiovascular Diabetology describes that maternal obesity and gestational diabetes can induce epigenetic remodeling in infants, potentially impacting metabolic and developmental pathways.

6 Mar 2023

Maternal obesity associated with adverse metabolic health outcomes in childhood

Research by the University of the Basque Country indicates that changes caused by maternal obesity could lead to adverse health outcomes in childhood.

3 Mar 2023

Epigenetic changes in the regulation of key stress gene detected in kids with abusive injuries

Epigenetic changes in the regulation of a key gene in the body's stress response system were detected in babies and young children with abusive injuries, as opposed to accidental, according to a pilot study published in the journal Pediatric Research.

2 Mar 2023

Tecan and Oxford Nanopore build alliance to create automated, seamless and fully compatible nanopore sequencing library preparation for any-length fragments of native DNA/RNA

The Tecan Group and Oxford Nanopore Technologies plc (Oxford Nanopore) today announce their collaboration to drive easier high-throughput nanopore library preparation in an automated, hands-free fashion.

From Tecan 27 Feb 2023

Innovative methodology to detect viral RNA

Experts from the University of Barcelona, the Institute for Advanced Chemistry of Catalonia, the Institute of Microelectronics of Barcelona and the Aragon Nanoscience and Materials Institute of Aragon —a joint institute of the CSIC and the University of Zaragoza— have developed a new method to detect RNA viruses based on the triplex-forming probe technology.

27 Feb 2023

The relationship between DNAm-based age acceleration measures in the prediction of cross-sectional and longitudinal health outcomes and mortality

Researchers assessed the association between deoxyribonucleic acid methylation (DNAm)-based clocks or aging measures and demographic and serological parameters in estimating health-associated outcomes, including deaths.

24 Feb 2023

Study may elucidate metformin's potential role in longevity through DNA methylation

A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 15, Issue 3, entitled, "Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity."

22 Feb 2023

Mount Sinai study sheds new light on the role of DNA methylation in Alzheimer's disease

Mount Sinai researchers have published a study in Alzheimer's & Dementia: The Journal of the Alzheimer's Association that sheds new light on the role of DNA methylation in Alzheimer's disease (AD).

22 Feb 2023

Research shows DNA methylation as a robust predictor of later life outcomes

A new study utilizing data from the Health and Retirement Study at the University of Michigan’s Institute for Social Research is offering a new look at the effects of aging and what they mean for population health.

22 Feb 2023

Study examines link between different epigenetic age measures and lung cancer risk

A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 15, Issue 3, entitled, "Epigenetic age and lung cancer risk in the CLUE II prospective cohort study."

17 Feb 2023

Brain cells may age faster in people with cocaine use disorder

A new study finds evidence from the DNA methylome that the biological age – different from the chronological age – of cells in Brodmann Area 9 of the prefrontal cortex might be greater in people with cocaine use disorder.

16 Feb 2023

Cocaine use disorder leads to changes in the 'methylome' of a brain region

Scientists tend to view substance addiction as primarily a disease of the brain. When we enjoy sex, food, music, or hobbies, regions of our brain within the reward pathway are flooded with pleasure-inducing dopamine.

14 Feb 2023

Long-term caloric restriction has a small effect on the DNA methylation measure of the pace of aging

Researchers assessed the impact of caloric restriction on biological aging among the comprehensive assessment of the long-term effects of reducing the intake of energy (CALERIE) randomized controlled trial participants.

13 Feb 2023

A single base-resolution sequencing methodology that sequences the two most common cytosine modifications in a single workflow

Researchers developed a WGS method that read four canonical DNA bases, viz., adenine (A), cytosine (C), guanine (G), and thymine (T) plus 5mC and 5hmC, epigenetic variants of unmodified C to yield an accurate six-letter digital readout in a single workflow.

9 Feb 2023

DNA Methylation News and Research

Further Reading

Analyzing DNA changes in the blood can improve prediction of type 2 diabetes risk

Early life adversity linked to accelerated neurobiological aging, raising vulnerability to depression and Alzheimer's

Ask the Expert: 7 Questions about Colorectal Cancer & Non-invasive Fecal DNA Testing

Age-induced methylation changes in the sperm epigenome contribute to offspring's medical problems

Investigating how gut microbiota affect neuroplasticity and neurodevelopment

Machine learning applications for the diagnosis, treatment and prognosis of cancer

How maternal obesity and gestational diabetes can impact DNA methylation in infants

Maternal obesity associated with adverse metabolic health outcomes in childhood

Epigenetic changes in the regulation of key stress gene detected in kids with abusive injuries

Tecan and Oxford Nanopore build alliance to create automated, seamless and fully compatible nanopore sequencing library preparation for any-length fragments of native DNA/RNA

Innovative methodology to detect viral RNA

The relationship between DNAm-based age acceleration measures in the prediction of cross-sectional and longitudinal health outcomes and mortality

Study may elucidate metformin's potential role in longevity through DNA methylation

Mount Sinai study sheds new light on the role of DNA methylation in Alzheimer's disease

Research shows DNA methylation as a robust predictor of later life outcomes

Study examines link between different epigenetic age measures and lung cancer risk

Brain cells may age faster in people with cocaine use disorder

Cocaine use disorder leads to changes in the 'methylome' of a brain region

Long-term caloric restriction has a small effect on the DNA methylation measure of the pace of aging

A single base-resolution sequencing methodology that sequences the two most common cytosine modifications in a single workflow

DNA Methylation eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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