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Discovery provides an understanding of the mechanisms of oocyte death and a way to identify potential clinical treatments for infertility

An immature egg's internal nutrient supply is critical to its survival, an insight that offers a new route to understanding and treating infertility due to egg death, according to Duke University Medical Center researchers.

9 Oct 2005

Long-term use of NSAIDs cuts the risk for oral cancer in smokers by half but increases risk of cardiovascular problems

An analysis of 20 years of data on the health of over 900 adults has found that long-term use of traditional nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen, cuts the risk for oral cancer in smokers by half.

9 Oct 2005

Fruits and vegetables can increase or decrease the activity and toxicity of orally-administered drugs

Eating fruits and vegetables is essential to living a long and healthy life, yet research has shown they can cause dangerous interactions with medicines.

5 Oct 2005

Protein secreted by the dog hookworm may advance vaccine development in humans

A paper published in this week's PLoS Medicine shows that vaccination against a protein secreted by the dog hookworm can protect against blood loss and anaemia caused by the same hookworm in dogs.

4 Oct 2005

Bacteria of different species can talk to each other using a common language

The interspecies crosstalk and misdirection could have important consequences for human health, said Bonnie L. Bassler, an HHMI investigator at Princeton University whose study was published in the September 29, 2005, issue of Nature.

4 Oct 2005

Plant-derived compounds appear to block the activity of an enzyme that triggers inflammation in joints

The findings came to light while the researchers were studying the wildly different ways in which cells in human blood vessels and joints respond to pressure gradients generated from liquid moving along their surface, a force called shear stress.

3 Oct 2005

First identification of the genetic basis of disease in a patient with a complex I assembly defect

Mitochondrial complex I deficiency is one of the most common defects in patients with mitochondrial disease. The deficiency results from a failure to assemble the enzyme properly, but the nature of the molecular chaperones that are necessary for this process in mammals have remained obscure.

3 Oct 2005

Nicotine has an unusual psychological property that may drive dependence

Associate Professor Athina Markou, Ph.D., who is in the Scripps Research Molecular and Integrative Neurosciences Department at Scripps Research’s La Jolla Campus, and Paul Kenny, Ph.D., a former Research Associate in her laboratory, report in an upcoming issue of the journal Neuropsychopharmacology that nicotine has an unusual psychological property that may drive dependence.

28 Sep 2005

Discovery may lead to development of more effective antibiotics

Researchers at the Georgia Institute of Technology and the John Innes Centre in the United Kingdom have uncovered a mechanism with which disease-causing bacteria may thwart the body's natural defense responses. The findings, which could ultimately lead to the development of more effective antibiotics, appear in the September 29, 2005 issue of the journal Nature.

28 Sep 2005

The immune mechanisms of atherosclerosis

Scientists are depicting a novel scheme for atherosclerosis development, suggesting that this pathology might result from an imbalance between pro-inflammatory processes and calming ones.

28 Sep 2005

Treatment of Nonalcoholic Fatty Liver Disease (NAFLD) in children

The Nonalcoholic Steatohepatitis (NASH) Clinical Research Network has launched its second clinical trial to study NASH, a liver disease that resembles alcoholic liver disease but occurs in patients who drink little or no alcohol. The first trial, launched in January of this year, focuses on adults, while the second trial studies the disease in children.

27 Sep 2005

Governments considering reclassifying some drugs from prescription to over-the-counter status

Governments in several countries with public Pharmacare and in a few provinces in Canada are considering reclassifying some drugs from prescription to over-the-counter status. In a Canadian Medical Association Journal essay, Lynd and colleagues comment on the economic effects of such changes.

27 Sep 2005

Pursuit of potential drugs and small molecules that target the IGF-1 receptor

Pharmaceutical companies around the world still come knocking on Renato Baserga, M.D.,'s door. And for good reason.

27 Sep 2005

Farnesyl transferase inhibitors may help chidren with Hutchinson-Gilford progeria syndrome

Johns Hopkins scientists have discovered that a drug currently being tested against cancers might help children with a rare, fatal condition called Hutchinson-Gilford progeria syndrome, which causes rapid, premature aging.

27 Sep 2005

Pulsing heart cell provides clues into how heart disease develops

A pulsing heart cell is giving Oregon Health & Science University researchers insight into how it sends and receives signals, and that's providing clues into how heart disease and other disorders develop.

27 Sep 2005

Chronically high levels of insulin may block specific hormones that trigger energy release into the body

Their findings, which may point to new approaches to developing improved treatment options for the disease, are published in the journal Nature.

26 Sep 2005

Nanogen issued patent relating to biological screening device

Nanogen announced today it was issued Patent No. 6,942,778, "Microstructure Apparatus and Method for Separating Differently Charged Molecules Using an Applied Electric Field" by the U.S. Patent and Trademark Office.

26 Sep 2005

Microchip system aims to reduce the number of animals used in the development of new drugs

Reducing the number of animals used in the development of new drugs is a priority for the pharmaceutical industry

26 Sep 2005

A new, less toxic way to treat malignant melanoma

A new, less toxic way to treat malignant melanoma (skin cancer) is being developed by medicinal chemists at Reading University. They have produced a range of prodrugs: compounds that offer the potential to be converted to toxic molecules only within the vicinity of tumours. These prodrugs aim to reduce the toxicity of treatment.

26 Sep 2005

Scientists reverse memory loss in mice with Alzheimer's

In mice, that had been genetically engineered to develop Alzheimer's disease, scientists were able to reverse the rodents' memory loss by reducing the amount of an enzyme that is crucial for the development of Alzheimer's disease.

26 Sep 2005

Enzyme News and Research

Discovery provides an understanding of the mechanisms of oocyte death and a way to identify potential clinical treatments for infertility

Long-term use of NSAIDs cuts the risk for oral cancer in smokers by half but increases risk of cardiovascular problems

Fruits and vegetables can increase or decrease the activity and toxicity of orally-administered drugs

Protein secreted by the dog hookworm may advance vaccine development in humans

Bacteria of different species can talk to each other using a common language

Plant-derived compounds appear to block the activity of an enzyme that triggers inflammation in joints

First identification of the genetic basis of disease in a patient with a complex I assembly defect

Nicotine has an unusual psychological property that may drive dependence

Discovery may lead to development of more effective antibiotics

The immune mechanisms of atherosclerosis

Treatment of Nonalcoholic Fatty Liver Disease (NAFLD) in children

Governments considering reclassifying some drugs from prescription to over-the-counter status

Pursuit of potential drugs and small molecules that target the IGF-1 receptor

Farnesyl transferase inhibitors may help chidren with Hutchinson-Gilford progeria syndrome

Pulsing heart cell provides clues into how heart disease develops

Chronically high levels of insulin may block specific hormones that trigger energy release into the body

Nanogen issued patent relating to biological screening device

Microchip system aims to reduce the number of animals used in the development of new drugs

A new, less toxic way to treat malignant melanoma

Scientists reverse memory loss in mice with Alzheimer's

Biochemistry eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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