Ganglion News and Research

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In anatomy, a ganglion (plural ''ganglia'') is a biological tissue mass, most commonly a mass of nerve cell bodies. Cells found in a ganglion are called ganglion cells, though this term is also sometimes used to refer specifically to retinal ganglion cells.

The loss of epigenetic information accelerates the aging process

A new study in the journal Cell aimed to determine whether epigenetic changes are a cause of mammalian aging.

15 Jan 2023

Do hPSC-derived retinal neurons possess intrinsic potential to form new synaptic connections after extraction from organoids?

Researchers successfully demonstrated that lab-grown retinal organoids made new synaptic connections, theoretically establishing their potential to treat blindness due to retinal degenerative diseases.

13 Jan 2023

Study describes a mechanism associated with the production of neuropathic pain

Neuropathic pain is a type of chronic pain caused by damage to the nervous system due mainly to metabolic diseases such as diabetes and arthritis, or to the side effects of some kinds of chemotherapy.

10 Jan 2023

Research shows re-formation of synaptic connectivity in dissociated retinal organoids

Retinal cells grown from stem cells can reach out and connect with neighbors, according to a new study, completing a "handshake" that may show the cells are ready for trials in humans with degenerative eye disorders.

4 Jan 2023

Newly identified genetic mutation may be a root cause of severe childhood glaucoma

An international team of scientists led by Mass Eye and Ear, a member of Mass General Brigham, and Boston Children's Hospital, has discovered a new genetic mutation that may be a root cause of severe cases of childhood glaucoma, a devastating condition that runs in families and can rob children of their vision by 3 years of age.

1 Dec 2022

Repetitive stress induces features of accelerated aging in the eye

New research from the University of California, Irvine, suggests aging is an important component of retinal ganglion cell death in glaucoma, and that novel pathways can be targeted when designing new treatments for glaucoma patients.

21 Nov 2022

Poor sleep increases the risk of glaucoma

Snoring, daytime sleepiness, insomnia, and sleep duration may increase the risk of glaucoma.

8 Nov 2022

Neuroscientists reveal precise connections between retinal nerve cells and the midbrain structure

For the first time, neuroscientists from Charité – Universitätsmedizin Berlin and the Max Planck Institute for Biological Intelligence (currently in the process of being established) have revealed the precise connections between sensory neurons inside the retina and the superior colliculus, a structure in the midbrain.

12 Sep 2022

How a key brain network responds to seasonal shifts in day length

A recent paper examined the difference in neuronal communication in the hypothalamic network that regulates physiological function in response to the photoperiod.

8 Sep 2022

Genetic variant associated with Alzheimer's disease plays a role in protecting against glaucoma

New research led by scientists at Mass Eye and Ear and Brigham and Women's Hospital, member hospitals of Mass General Brigham, reveals the role that a genetic variant associated with Alzheimer's disease, APOE4, plays in protecting against glaucoma.

16 Aug 2022

Stem cell models help determine previously unknown genetic markers of glaucoma

Stem cell models of the retina and optical nerve have been used to identify previously unknown genetic markers of glaucoma, in research jointly led by scientists from the Garvan Institute of Medical Research, the University of Melbourne, and the Centre for Eye Research Australia.

9 Jun 2022

Detailed genetic roadmap of glaucoma will help develop new drugs to combat the disease

A new, detailed genetic roadmap of glaucoma – the world's leading cause of irreversible blindness – will help researchers develop new drugs to combat the disease, by identifying potential target areas to stall or reverse vision loss.

8 Jun 2022

Gene therapy for degenerative retinal disease has no safety concerns but fails to improve vision loss

A 28-patient phase 1 gene therapy clinical trial for the degenerative retinal disease Leber hereditary optic neuropathy (LHON) found no significant safety concerns; however, treatment failed to improve or slow vision loss, with even the highest dose. LHON affects the optic nerve, which carries visual signals from the light-sensing retina to the brain.

1 Jun 2022

Specific neural circuit in mice can help detect the dimmest shadows possible

Mice use a specific neural pathway to detect shadows, and it can detect just about the dimmest shadows possible, according to new research from Aalto University and the University of Helsinki. The human eye has the same neural circuit, which researchers think could be used to probe visual diseases at unprecedented resolution.

26 May 2022

Ganglion News and Research

Further Reading

The loss of epigenetic information accelerates the aging process

Do hPSC-derived retinal neurons possess intrinsic potential to form new synaptic connections after extraction from organoids?

Study describes a mechanism associated with the production of neuropathic pain

Research shows re-formation of synaptic connectivity in dissociated retinal organoids

Newly identified genetic mutation may be a root cause of severe childhood glaucoma

Repetitive stress induces features of accelerated aging in the eye

Poor sleep increases the risk of glaucoma

Neuroscientists reveal precise connections between retinal nerve cells and the midbrain structure

How a key brain network responds to seasonal shifts in day length

Genetic variant associated with Alzheimer's disease plays a role in protecting against glaucoma

Stem cell models help determine previously unknown genetic markers of glaucoma

Detailed genetic roadmap of glaucoma will help develop new drugs to combat the disease

Gene therapy for degenerative retinal disease has no safety concerns but fails to improve vision loss

Specific neural circuit in mice can help detect the dimmest shadows possible

Research shows existence of a link between atherosclerotic plaques and the central nervous system

Study evaluates the ocular tropism and the possible ocular transmission of SARS-CoV-2 in animal models

Trigeminal ganglia cell atlas implicates several cell types in migraine

Researchers use optoacoustics for high-precision neuromodulation

Cell fusion could be a potential therapeutic strategy to treat retinal damage

A ubiquitous protein may be key to the survival of neurons most impacted by glaucoma

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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