Glomerulosclerosis News and Research

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Glomerulosclerosis refers to the scarring of the glomeruli in the kidneys following any type of insult.

Genetic analysis reveals hidden causes of chronic kidney disease in adults

Chronic kidney disease (CKD) is extremely prevalent among adults, affecting over 800 million individuals worldwide.

3 Apr 2024

Protective genetic variant shields Black Americans from kidney disease risk

Many Black Americans who are thought to have a high risk of developing kidney disease possess a protective genetic variant that nullifies the extra risk, a new study from Columbia researchers has found.

12 Dec 2023

Sparsentan may be a new treatment option for focal segmental glomerulosclerosis

Focal segmental glomerulosclerosis (FSGS) is a rare kidney disorder that affects children and adults, and can lead to kidney failure.

3 Nov 2023

High-impact clinical trial results to be presented at ASN Kidney Week 2023

The results of numerous high-impact clinical trials that could affect kidney-related medical care will be presented in-person at ASN Kidney Week 2023 November 1–November 5.

3 Nov 2023

Study supports vaccination for COVID-19 in patients with glomerular diseases

Among 2,055 adults with a wide range of glomerular diseases, the COVID-19 vaccination did not adversely affect kidney function or worsen kidney damage and appeared safe in this population.

5 Sep 2023

NLRP3 inflammasome plays a role in podocyte aging

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, entitled, "Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span."

8 Aug 2023

New research sheds light on gut-kidney axis in diabetes and diabetic nephropathy

Researchers explored gut microbiota composition to evaluate the association between the microbes and diabetic clinical phenotypes.

2 Aug 2023

New treatment pathway identified for patients with idiopathic nephrotic syndrome

With funding from charity Kidney Research UK, Dr Carl May from Bristol Medical School and his team have identified a new treatment pathway for patients with non-genetic (idiopathic) nephrotic syndrome (INS), targeting a still unknown factor that causes the progression towards kidney failure.

13 Apr 2023

Study finds low absolute risk of glomerular disease relapse associated with COVID-19 vaccination

Several reports have described a relapse of certain autoimmune kidney diseases in patients after they've received COVID-19 vaccines, but it's unclear if this association is real or a coincidence.

4 Nov 2022

Digital spatial profiling of individual glomeruli from HIV and COVID-19 patients

Now, a new study posted to the bioRxiv* server by scientists from the University of Washington explores the use of NanoString’s GeoMx digital spatial profiling (DSP) to investigate CG caused by HIV and SARS-Cov-2 infections.

14 Sep 2021

Oral antidiabetic medication provides kidney protection in focal segmental glomerulosclerosis

Focal segmental glomerulosclerosis (FSGS) is a rare form of kidney inflammation (glomerulonephritis) in which the glomeruli become increasingly scarred (sclerotic), leading to progressive loss of kidney function.

7 Jun 2021

Study demonstrates that the main creators of SARS-CoV-2 mutations are vaccine-suppressed

A new research paper posted to the medRxiv* preprint server describes the changes in genomic sequence observed during the course of infection in a patient on the drug tacrolimus, along with steroids, both potent immunosuppressants, and who also received convalescent plasma treatment. These mutations were observed to occur within three weeks from infection.

14 Apr 2021

UH researcher working to identify potential new therapeutic targets for kidney disease

Among the primary forms of kidney disease, focal segmental glomerulosclerosis (FSGS) is the most common and is marked by high circulating levels of the suPAR protein (soluble urokinase-type plasminogen activator receptor).

13 Jan 2021

Mild electrical stimulation with heat shock exerts protective effect against nephrotic syndrome

A research team from Kumamoto University in Japan has found that the combination of weak pulsed electrical current and heat exerts anti-inflammatory and anti-fibrotic effects in the kidneys, as well as a protective effect against nephrotic syndrome (NS) by inhibiting apoptosis (cell death) of kidney cells.

30 Nov 2020

Proteinuria reduction slows kidney decline in patients with focal segmental glomerulosclerosis

Reducing the amount of protein in the urine of patients with focal segmental glomerulosclerosis (FSGS), a rare disease in which scar tissue forms on the parts of the kidneys that filter waste from the blood, can significantly slow declines in kidney function and extend time before patients' kidneys fail, a new analysis by a Children's National Hospital researcher and her colleagues shows.

10 Aug 2020

Glomerulosclerosis News and Research

Further Reading

Genetic analysis reveals hidden causes of chronic kidney disease in adults

Protective genetic variant shields Black Americans from kidney disease risk

Sparsentan may be a new treatment option for focal segmental glomerulosclerosis

High-impact clinical trial results to be presented at ASN Kidney Week 2023

Study supports vaccination for COVID-19 in patients with glomerular diseases

NLRP3 inflammasome plays a role in podocyte aging

New research sheds light on gut-kidney axis in diabetes and diabetic nephropathy

New treatment pathway identified for patients with idiopathic nephrotic syndrome

Study finds low absolute risk of glomerular disease relapse associated with COVID-19 vaccination

Digital spatial profiling of individual glomeruli from HIV and COVID-19 patients

Oral antidiabetic medication provides kidney protection in focal segmental glomerulosclerosis

Study demonstrates that the main creators of SARS-CoV-2 mutations are vaccine-suppressed

UH researcher working to identify potential new therapeutic targets for kidney disease

Mild electrical stimulation with heat shock exerts protective effect against nephrotic syndrome

Proteinuria reduction slows kidney decline in patients with focal segmental glomerulosclerosis

ACE inhibition in kidney could influence pathogenesis of SARS-CoV-2

Study: MafB protein may protect against renal failure

Study suggests ROBO2 pathway as therapeutic target for kidney diseases

Lipo-ImmunoTech receives grant to develop novel adoptive cell therapy technology for cancer

Low socioeconomic status associated with certain kidney diseases

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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