Glomerulosclerosis News and Research

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Glomerulosclerosis refers to the scarring of the glomeruli in the kidneys following any type of insult.

Study supports vaccination for COVID-19 in patients with glomerular diseases

Among 2,055 adults with a wide range of glomerular diseases, the COVID-19 vaccination did not adversely affect kidney function or worsen kidney damage and appeared safe in this population.

5 Sep 2023

NLRP3 inflammasome plays a role in podocyte aging

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, entitled, "Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span."

8 Aug 2023

New research sheds light on gut-kidney axis in diabetes and diabetic nephropathy

Researchers explored gut microbiota composition to evaluate the association between the microbes and diabetic clinical phenotypes.

2 Aug 2023

New treatment pathway identified for patients with idiopathic nephrotic syndrome

With funding from charity Kidney Research UK, Dr Carl May from Bristol Medical School and his team have identified a new treatment pathway for patients with non-genetic (idiopathic) nephrotic syndrome (INS), targeting a still unknown factor that causes the progression towards kidney failure.

13 Apr 2023

Study finds low absolute risk of glomerular disease relapse associated with COVID-19 vaccination

Several reports have described a relapse of certain autoimmune kidney diseases in patients after they've received COVID-19 vaccines, but it's unclear if this association is real or a coincidence.

4 Nov 2022

Digital spatial profiling of individual glomeruli from HIV and COVID-19 patients

Now, a new study posted to the bioRxiv* server by scientists from the University of Washington explores the use of NanoString’s GeoMx digital spatial profiling (DSP) to investigate CG caused by HIV and SARS-Cov-2 infections.

14 Sep 2021

Oral antidiabetic medication provides kidney protection in focal segmental glomerulosclerosis

Focal segmental glomerulosclerosis (FSGS) is a rare form of kidney inflammation (glomerulonephritis) in which the glomeruli become increasingly scarred (sclerotic), leading to progressive loss of kidney function.

7 Jun 2021

Study demonstrates that the main creators of SARS-CoV-2 mutations are vaccine-suppressed

A new research paper posted to the medRxiv* preprint server describes the changes in genomic sequence observed during the course of infection in a patient on the drug tacrolimus, along with steroids, both potent immunosuppressants, and who also received convalescent plasma treatment. These mutations were observed to occur within three weeks from infection.

14 Apr 2021

UH researcher working to identify potential new therapeutic targets for kidney disease

Among the primary forms of kidney disease, focal segmental glomerulosclerosis (FSGS) is the most common and is marked by high circulating levels of the suPAR protein (soluble urokinase-type plasminogen activator receptor).

13 Jan 2021

Mild electrical stimulation with heat shock exerts protective effect against nephrotic syndrome

A research team from Kumamoto University in Japan has found that the combination of weak pulsed electrical current and heat exerts anti-inflammatory and anti-fibrotic effects in the kidneys, as well as a protective effect against nephrotic syndrome (NS) by inhibiting apoptosis (cell death) of kidney cells.

30 Nov 2020

Proteinuria reduction slows kidney decline in patients with focal segmental glomerulosclerosis

Reducing the amount of protein in the urine of patients with focal segmental glomerulosclerosis (FSGS), a rare disease in which scar tissue forms on the parts of the kidneys that filter waste from the blood, can significantly slow declines in kidney function and extend time before patients' kidneys fail, a new analysis by a Children's National Hospital researcher and her colleagues shows.

10 Aug 2020

ACE inhibition in kidney could influence pathogenesis of SARS-CoV-2

The dynamics of angiotensin-converting enzyme 2 (ACE2) expression in the kidney could have implications for the infectivity and pathogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), say researchers.

24 Jun 2020

Study: MafB protein may protect against renal failure

Focal segmental glomerulosclerosis (FSGS) is a common cause of steroid-resistant nephrotic syndrome, a type of kidney disease that is accompanied by massive urinary protein loss and that may progress to end-stage renal disease.

5 Jun 2020

Study suggests ROBO2 pathway as therapeutic target for kidney diseases

Researchers have published a new study that suggests a signaling pathway called ROBO2 is a therapeutic target for kidney diseases, specifically kidney podocyte injury and glomerular diseases.

4 May 2020

Lipo-ImmunoTech receives grant to develop novel adoptive cell therapy technology for cancer

Lipo-ImmunoTech, LLC, a startup based in Charleston, South Carolina, recently received a Phase I Small Business Technology Transfer grant of just over $224,000 to continue to develop its novel adoptive cell therapy technology for cancer.

2 May 2020

Low socioeconomic status associated with certain kidney diseases

A new study found an inverse association between socioeconomic status and certain kidney diseases. The findings appear in an upcoming issue of CJASN.

20 Feb 2020

InDepth Pharmaceuticals to commercialize novel technique to predict kidney transplant success

InDepth Pharmaceuticals, founded by Deepak Nihalani, Ph.D., the SmartState Endowed Chair in Renal Disease Biomarkers at the Medical University of South Carolina, has taken a vital step toward commercializing an innovative diagnostic technique that could better predict kidney transplant success in patients with focal segmental glomerulosclerosis (FSGS), a kidney disease that often leads to end-stage renal failure.

14 Jan 2020

Machine learning may augment diagnostics of kidney disease

Two new studies reveal that modern machine learning--a branch of artificial intelligence in which systems learn from data, identify patterns, and make decisions--may augment traditional diagnostics of kidney disease. The findings appear in an upcoming issue of JASN.

6 Sep 2019

Men are affected by kidney failure more often than women, new analysis shows

Our kidneys filter out toxic waste from the blood and regulate the fluid balance in the body as well as the balance of electrolytes and acid/base amongst others. Kidneys are important organs whose functions most of us take for granted, but when kidneys silently stop working this can create a life threatening situation.

27 Feb 2019

Myriad biological, societal factors that impact CKD severity for children of African descent

Myriad biological and societal factors can impact the occurrence and accelerate progression of chronic kidney disease for children of African descent - including preterm birth, exposure to toxins during gestation and lower socioeconomic status - and can complicate these children's access to effective treatments, according to an invited commentary published in the November 2018 edition of American Journal of Kidney Diseases.

21 Nov 2018