Glucocorticoid News and Research

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Glucocorticoid is a compound that belongs to the family of compounds called corticosteroids (steroids). Glucocorticoids affect metabolism and have anti-inflammatory and immunosuppressive effects. They may be naturally produced (hormones) or synthetic (drugs).

ACR’s updated guideline provides recommendations on treatment of glucocorticoid-induced osteoporosis

The American College of Rheumatology's updated clinical guideline for the prevention and treatment of glucocorticoid-induced osteoporosis is now available online.

7 Jun 2017

Weekly doses of steroids help hasten recovery in muscle injuries

Weekly doses of glucocorticoid steroids, such as prednisone, help speed recovery in muscle injuries, reports a new Northwestern Medicine study. The weekly steroids also repaired muscles damaged by muscular dystrophy.

17 May 2017

Switching off glucocorticoid signaling in bone could protect against diet-induced metabolic disturbances

A high-calorie diet, even without a high amount of fat, causes bone loss, and both high-calorie and high-fat diets induce excessive fat gain and insulin resistance, a new study conducted in mice finds.

4 Apr 2017

Endostatin can decrease proliferation of castration-resistant prostate cancer cells

Failure of hormone deprivation therapy, which is used to slow prostate cancer in patients, leads to castration-resistant prostate cancer, a lethal form of advanced disease with limited treatment options.

10 Mar 2017

Maternal stress can affect growth of fetal muscles, study shows

Born too soon, she weighed just over 1 pound at birth and spent the first three months of her life in the neonatal intensive care unit, fighting to live.

6 Feb 2017

Researchers provide insights into effects of microgravity on bone tissue

As is well-known, space flights bring with them a unique set of health hazards. That includes bone and muscle deterioration. Loss of bone density is currently one of the most serious problems for astronauts.

28 Jan 2017

Real-time study of medaka fish aboard ISS sheds light on bone metabolism under microgravity

Tokyo Institute of Technology research: Gravitational biology: Real time imaging and transcriptome analysis of medaka aboard space station

11 Jan 2017

Identifying gene defects may help develop individualised treatments for prostate cancer patients

The current method of treating prostate cancer involves identifying gene defects, which could help with the diagnosis of cancer and the development of individualised cancer treatments for patients.

7 Nov 2016

Researchers elucidate molecular mechanisms underlying negative effects of early-life stress

Scientists have long known that chronic exposure to psychosocial stress early in life can lead to an increased vulnerability later in life to diseases linked to immune dysfunction and chronic inflammation, including arthritis, asthma, cancer, diabetes, heart disease and even mental illness.

24 Oct 2016

Standard hormone supplement after radiotherapy could increase risk of prostate cancer recurrence

A new study at the University of York has shown that a standard hormone supplement, used to boost energy levels in prostate cancer patients following radiotherapy, could potentially increase the chances of the cancer returning.

18 Oct 2016

$New review looks at complexity of fracture epidemiology in diabetes$

New review looks at complexity of fracture epidemiology in diabetes

Due to the ageing of populations as well as increasing obesity and adverse lifestyle factors, type 2 diabetes (T2D) is reaching epidemic proportions in many parts of the world.

17 Oct 2016

Wayne State receives NIH grant to study use of opioid addiction drug to fight relapse in recovering addicts

A team led by Wayne State University School of Medicine researcher Mark Greenwald, Ph.D., will use a four-year, $2,279,723 competitively renewed grant from the National Institute on Drug Abuse of the National Institutes of Health to explore whether the opioid addiction treatment medication buprenorphine can decrease the magnitude and/or duration of responses to stressors faced by recovering addicts.

15 Oct 2016

Endocrine Society issues new guidelines on hypopituitarism

The Endocrine Society today issued a Clinical Practice Guideline that recommends treating insufficient hormone levels in individuals with hypopituitarism by replacing hormones at levels as close to the body's natural patterns as possible.

13 Oct 2016

Combination drug therapy safe, effective in treating asthma patients

A post-marketing safety study mandated by the U.S. Food and Drug Administration has shown that a combination drug therapy for the treatment of asthma is safe and effective.

1 Sep 2016

Study shows how caffeine counteracts age-related cognitive deficits in animals

A study published in the journal Scientific Reports from Nature publishing group, describes the mechanism by which caffeine counteracts age-related cognitive deficits in animals.

30 Aug 2016

Scientists discover novel genetic mutation linked to osteonecrosis of femoral head

Scientists at the Research Institute of McGill University Health Centre have discovered a new genetic mutation linked to osteonecrosis of the hip, specifically the femoral head - the spherical-shaped mass at the top of the femur.

14 Jul 2016

Positive environment can reverse trauma-related behavioral alterations in mice

Traumatic experiences in childhood increase the risk of developing behavioral and psychiatric disorders later in life. It is also known that the consequences of a trauma can likewise be observed in the children of people affected even if those children have themselves not experienced any trauma.

24 Jun 2016

New mice study unveils mystery of why chronic stress, depression can lead to bone loss

A new study has helped to unveil the mystery of why chronic stress and depression can lead to bone loss and increase the risk of fractures.

19 May 2016

Diabetes risk linked to increased dosage, duration and timing of steroids

Glucocorticoid (or steroid) therapy, prescribed to around half of patients with rheumatoid arthritis, is a known risk factor for developing diabetes. A study from The University of Manchester has found how the risk of diabetes increases in relation to the dosage, duration and timing of steroids.

4 May 2016

Caltech researchers identify gene that causes severe insomnia when overactivated

Caltech biologists have performed the first large-scale screening in a vertebrate animal for genes that regulate sleep, and have identified a gene that when overactivated causes severe insomnia. Expression of the gene, neuromedin U (Nmu), also seems to serve as nature's stimulant--fish lacking the gene take longer to wake up in the morning and are less active during the day.

18 Feb 2016