Glycoprotein News and Research

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The relationship between natural plant extracts and SARS-CoV-2

Researchers explored plants as an extensive resource of molecules with potential therapeutic action against SARS-CoV-2 and debunked misconceptions.

3 Feb 2023

New study suggests Omicron BA.1 breakthrough infection drives long-term remodeling of memory B cell repertoire in vaccinated populations

A recent study posted on the bioRxiv* preprint server has longitudinally characterized the MBC repertoire and humoral response after Omicron BA.1 breakthrough infection in individuals vaccinated with the COVID-19 mRNA vaccine.

1 Feb 2023

Structure and function of the first FDA-approved treatment for Ebola virus discovered

Scientists at La Jolla Institute for Immunology (LJI) have uncovered the structure and function of the first FDA-approved treatment for Zaire ebolavirus (Ebola virus).

30 Jan 2023

Experimental vaccine against Marburg virus shows promise in first-in-human clinical trial

A newly published paper in The Lancet shows that an experimental vaccine against Marburg virus (MARV) was safe and induced an immune response in a small, first-in-human clinical trial.

30 Jan 2023

Atomic-level computer model of the H1N1 virus reveals new vulnerabilities

According to the World Health Organization, each year there are an estimated 1 billion cases of influenza, between 3-5 million severe cases and up to 650,000 influenza-related respiratory deaths globally.

25 Jan 2023

Breathing and tilting motions of influenza glycoproteins could be exploited to better defend against flu

The potential "tripledemic" of influenza, SARS-CoV-2 and RSV (respiratory syncytial virus) infection continues to be a concern.

25 Jan 2023

New trial evaluates Omicron BA.1–adapted BNT162b2 vaccine in older adults

Researchers reported the findings of the phase III trial evaluating the Omicron BA.1–adapted mono and bivalent BNT162b2 coronavirus disease 2019 (COVID-19) vaccine in 55-year-old adults. These individuals had already received three 30μg doses of the BNT162b2 vaccine.

20 Jan 2023

Study elucidates the potential role of STRO-001 in B-cell non-Hodgkin lymphoma

A new research paper was published in Oncotarget's Volume 14 on January 12, 2023, entitled, "Targeting CD74 in B-cell non-Hodgkin lymphoma with the antibody-drug conjugate STRO-001."

18 Jan 2023

Epitope mapping reveals the humoral responses against the main SARS-CoV-2 structural proteins in infected patients from Africa

Researchers performed immunoglobulin (Ig)M and IgG epitope mapping against 487 SARS-CoV-2 peptides.

18 Jan 2023

The diverse mechanisms by which galectins can regulate adaptive and innate immune responses

Researchers explored ways galectins can impact immunity and discussed the opportunities and challenges in the field.

18 Jan 2023

Do hPSC-derived retinal neurons possess intrinsic potential to form new synaptic connections after extraction from organoids?

Researchers successfully demonstrated that lab-grown retinal organoids made new synaptic connections, theoretically establishing their potential to treat blindness due to retinal degenerative diseases.

13 Jan 2023

Scientists explore synthesis of griffithsin in cell-free systems

A new study described the cell-free manufacturing of griffithsin (GRFT), a broad-spectrum antiviral protein.

28 Dec 2022

Researchers present a new strategy for self-adjuvanting vaccine development

This new article publication from Acta Pharmaceutica Sinica B, discusses a fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist KRN-7000 as built-in adjuvant effectively protects mice from tumor development.

23 Dec 2022

Hybrid immunity from mRNA vaccines and breakthrough Omicron infections induces stronger immune responses against Omicron BQ.1.1

Researchers evaluated plasma samples from individuals vaccinated with a fourth booster dose of mono- or bivalent mRNA SARS-CoV-2 vaccine to evaluate the recognition and neutralization capacity against the ancestral (D614G) strain and the Omicron BQ.1.1 subvariant.

23 Dec 2022

T-cell immunity remains effective against SARS-CoV-2 Omicron subvariants

Omicron subvariants effectively escape B-cell immune responses by modifying neutralizing antibody epitopes.

21 Dec 2022

Trial of three vaccines for Zaire Ebola virus disease

Researchers perform two randomized controlled trials to determine immunogenicity and safety of three Ebola vaccines.

20 Dec 2022

Study identifies four new monoclonal antibodies with broad neutralizing potencies that target conserved SARS-CoV-2 epitopes

Researchers described four novel monoclonal antibodies with potent and broad neutralization activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, including the current globally dominant Omicron BA.4/BA.5.

20 Dec 2022

Safety and immunogenicity of the Omicron BA.4/BA.5-containing bivalent booster mRNA-1273.222

Researchers evaluated the immunogenicity and safety of the COVID-19 bivalent mRNA vaccine mRNA-1273.222 and tested the neutralizing ability of the two bivalent vaccines — mRNA-1273.222 and mRNA-1273.214 — against the newly emergent Omicron subvariants.

19 Dec 2022

Research reveals that a viral toxin may contribute to the severity of COVID-19

Researchers determine whether the SARS-CoV-2 spike protein influences endothelial and epithelial barrier dysfunction and vascular leakage.

14 Dec 2022

What is the relation between COVID-19 vaccination and new POTS-related diagnoses?

Researchers assessed the association between POTS and SARS-CoV-2 infections and COVID-19 vaccinations.

14 Dec 2022

Glycoprotein News and Research

The relationship between natural plant extracts and SARS-CoV-2

New study suggests Omicron BA.1 breakthrough infection drives long-term remodeling of memory B cell repertoire in vaccinated populations

Structure and function of the first FDA-approved treatment for Ebola virus discovered

Experimental vaccine against Marburg virus shows promise in first-in-human clinical trial

Atomic-level computer model of the H1N1 virus reveals new vulnerabilities

Breathing and tilting motions of influenza glycoproteins could be exploited to better defend against flu

New trial evaluates Omicron BA.1–adapted BNT162b2 vaccine in older adults

Study elucidates the potential role of STRO-001 in B-cell non-Hodgkin lymphoma

Epitope mapping reveals the humoral responses against the main SARS-CoV-2 structural proteins in infected patients from Africa

The diverse mechanisms by which galectins can regulate adaptive and innate immune responses

Do hPSC-derived retinal neurons possess intrinsic potential to form new synaptic connections after extraction from organoids?

Scientists explore synthesis of griffithsin in cell-free systems

Researchers present a new strategy for self-adjuvanting vaccine development

Hybrid immunity from mRNA vaccines and breakthrough Omicron infections induces stronger immune responses against Omicron BQ.1.1

T-cell immunity remains effective against SARS-CoV-2 Omicron subvariants

Trial of three vaccines for Zaire Ebola virus disease

Study identifies four new monoclonal antibodies with broad neutralizing potencies that target conserved SARS-CoV-2 epitopes

Safety and immunogenicity of the Omicron BA.4/BA.5-containing bivalent booster mRNA-1273.222

Research reveals that a viral toxin may contribute to the severity of COVID-19

What is the relation between COVID-19 vaccination and new POTS-related diagnoses?

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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