Haloperidol News and Research

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Haloperidol is a typical antipsychotic. It is in the butyrophenone class of antipsychotic medications and has pharmacological effects similar to the phenothiazines.

Roundworm study suggests alternatives for treatment of schizophrenia

A group of Brazilian scientists have long conducted experiments with roundworms to investigate the role of schizophrenia-linked genes in patients' response to antipsychotic drugs. The results obtained thus far point to new ways of understanding resistance to certain classes of medication.

20 Mar 2019

Changing drugs, deprescribing do not lower severity and duration of delirium in ICU patients

The results of two new Regenstrief Institute trials published in the Journal of the American Geriatrics Society underscore and confirm the need to look to options other than medication to lower the duration or severity of delirium in intensive care unit patients.

6 Mar 2019

Study highlights need for personalized approach to treat ICU acquired delirium

A population heath study from the Regenstrief Institute and Indiana University Center for Aging Research has determined that halo, did not benefit elective thoracic surgery ICU patients when given prophylactically, with the possible exception of those who have had surgery to remove their esophagus.

14 Dec 2018

Researchers explore use of antipsychotic medications in older adults following heart surgery

Delirium is the medical term for an abrupt, rapid change in mental function that goes well beyond the typical forgetfulness of aging.

21 Aug 2018

Prophylactic use of haloperidol does not reduce delirium burden

Prophylactic use of the drug haloperidol does not help to prevent delirium in intensive care patients or improve their chances of survival. Therefore, there is no reason anymore to administer the drug as a preventive measure to reduce the burden of delirium.

21 Feb 2018

Study shows efficacy of antipsychotic as adjunctive therapy for gastroparesis in emergency department

Haloperidol is an effective first-line agent in combination with standard analgesic and antiemetic agents for the treatment of gastroparesis in the emergency department.

26 Oct 2017

UC Irvine pharmacology researchers unearth potential roots of schizophrenia

An abundance of an amino acid called methionine, which is common in meat, cheese and beans, may provide new clues to the fetal brain development that can manifest in schizophrenia, University of California, Irvine pharmacology researchers report in the journal Molecular Psychiatry.

16 Aug 2017

Harris Health System expert offers guidance to prevent drug-induced photosensitivity

Wanting a tan or simply enjoying the outdoors during the summer can expose skin to the effects of ultraviolet rays- a problem complicated for people taking certain medications, warns a Harris Health System expert.

10 Jul 2017

Powerful pain medicine may help reduce vision damage of glaucoma

The tip of our optic nerve is typically the first place injured by glaucoma. Now researchers want to know if the powerful pain medicine (+)-pentazocine can help avoid the damage.

2 May 2017

Two research studies on new molecules could potentially treat Alzheimer's disease

This year, results have been published of two significant research studies about molecules that could potentially treat Alzheimer's disease.

30 Dec 2016

Antipsychotic drug use linked to 60% increased risk of mortality among people with Alzheimer's disease

Antipsychotic drug use is associated with a 60 percent increased risk of mortality among persons with Alzheimer's disease, shows a recent study from the University of Eastern Finland.

14 Dec 2016

Measuring the activity of a mouse brain from a single snapshot

Drs Nicolas Renier and Zhuhao Wu are post-doctoral fellows in the laboratory of Marc Tessier-Lavigne, Carson Family Professor and head of the Laboratory of Brain Development and Repair and President of Rockefeller University in New York. Over recent years, they have co-developed methodologies for new imaging techniques applying light sheet microscopy. Their latest work shows the study of neuronal activity in intact brains.

12 Oct 2016

Schizophrenia drug slows pancreatic tumor growth in mice

A receptor for the dopamine neurotransmitter promotes growth and spread of pancreatic cancer -- and schizophrenia drugs, which block the function of this receptor, slowed tumor growth and metastatic spread in mice, according to researchers at McGill University and the German Cancer Research Center.

7 Sep 2016

Scientists find ketamine as effective sedative for treating highly-agitated patients prior to hospitalisation

Scientists have shown that ketamine is far more effective than the more commonly used haloperidol for treating highly-agitated patients prior to hospitalisation.

23 May 2016

Coprophagia linked to neurodegenerative dementia

Coprophagia, eating one's feces, is common in animals but rarely seen in humans. Mayo Clinic researchers reviewed the cases of a dozen adult patients diagnosed with coprophagia over the past 20 years and found that the behavior is associated with a wide range of neuropsychiatric disorders, particularly neurodegenerative dementias.

20 May 2016

Warning of increased mortality risk for PD patients taking antipsychotics

Researchers have found a more than twofold increase in the risk of death among patients with Parkinson's disease who take antipsychotics, particularly typical antipsychotics.

23 Mar 2016

Antipsychotic drugs may do significantly more harm to Parkinson's disease patients

At least half of Parkinson's disease patients experience psychosis at some point during the course of their illness, and physicians commonly prescribe antipsychotic drugs, such as quetiapine, to treat the condition. However, a new study by researchers at the Perelman School of Medicine at the University of Pennsylvania, the University of Michigan Medical School, and the Philadelphia and Ann Arbor Veterans Affairs Medical Centers and suggests that these drugs may do significantly more harm in a subset of patients.

21 Mar 2016

Brain circuit problem may contribute to auditory hallucinations of schizophrenia

St. Jude Children's Research Hospital scientists have identified problems in a connection between brain structures that may predispose individuals to hearing the "voices" that are a common symptom of schizophrenia. The work appears in the June 6 issue of the journal Science.

6 Jun 2014

Little efficacy difference between old and new antipsychotics

Older and second-generation long-acting antipsychotics have broadly similar clinical efficacy, shows a randomised trial in JAMA.

21 May 2014

Novartis to present updates on broad cancer portfolio at ASH and SABCS symposiums

Novartis will present updates on its broad cancer portfolio with more than 240 abstracts at the upcoming American Society of Hematology (ASH) annual meeting and CTRC-AACR San Antonio Breast Cancer Symposium (SABCS).

4 Dec 2013