Haloperidol News and Research

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Haloperidol is a typical antipsychotic. It is in the butyrophenone class of antipsychotic medications and has pharmacological effects similar to the phenothiazines.

Changes in dopamine levels in the brain affect emotion-recognition

Emotion-recognition among people with disorders such as Parkinson's disease or schizophrenia may be affected by changes in the levels of dopamine in the brain, say researchers at the University of Birmingham.

24 May 2022

Study shows massive variations in prescribing of “comfort kit” medications by hospice agencies

When a person nearing the end of their life enters hospice care, their hospice agency's doctors may prescribe a "comfort kit" of small amounts of medications that their caregivers can give them in case of urgent, distressing symptoms such as severe anxiety, agitation, delirium, nausea and more.

13 May 2022

Dopamine plays a significant role in recognizing human emotions, new study reveals

The neurotransmitter dopamine, famous for its role in reward, is also involved in recognizing emotions, according to new research published in JNeurosci.

3 May 2022

Antipsychotic drugs associated with increase in risk of breast cancer

Researchers at Washington University School of Medicine in St. Louis have found that many commonly prescribed antipsychotic medications are associated with a significant increase in risk of breast cancer.

6 Dec 2021

Scientists use anti-psychotics to treat flies displaying behavioral problems linked to schizophrenia-associated genes

Scientists have successfully treated flies displaying behavioral problems linked to newly discovered schizophrenia-associated genes in humans, using common anti-psychotics.

20 May 2021

Mice experiencing hallucination-like events provide clues to understand psychosis

The humble lab mouse has provided invaluable clues to understanding diseases ranging from cancer to diabetes to COVID-19. But when it comes to psychiatric conditions, the lab mouse has been sidelined, its rodent mind considered too different from that of humans to provide much insight into mental illness.

1 Apr 2021

Study explains why antipsychotic medications lead to weight gain, promote metabolic syndrome

Why do patients who receive antipsychotic medications to manage schizophrenia and bipolar disorder quickly gain weight and develop prediabetes and hyperinsulemia?

15 Feb 2021

Transcriptomics identifies possible COVID-19 therapies

By using a diverse set of transcriptomic SARS-CoV-2 signatures, US researchers put to use their previously developed drug repositioning pipeline to pinpoint potential drug candidates for the treatment of coronavirus disease (COVID-19). The study is currently available on bioRxiv preprint server.

26 Oct 2020

GlobalData: Patients treated for ICU delirium will increase as COVID-19 outbreak continues

An estimated 70–80% of ventilated patients will experience ICU delirium, which causes patients to enter a confused state and can lead to long-term cognitive impairments and memory deficits. GlobalData, therefore, expects to see an increase in the administration of pharmacological treatments for ICU delirium as the COVID-19 outbreak continues.

22 May 2020

What are the challenges facing palliative care during COVID-19?

The current COVID-19 outbreak affecting 180 countries and territories across six continents is taking its toll on healthcare systems globally. In particular, there is growing pressure on and concern for triage and palliative care departments. Now, researchers from the University of Toronto, Université Laval, Québec, and the University of Ottawa have published a new study titled, “Pandemic palliative care: beyond ventilators and saving lives,” in the latest issue of the journal Canadian Medical Association Journal that looks to address the challenges in providing palliative care during a viral pandemic.

1 Apr 2020

How cannabis interacts with medications

A new practice guideline published in the journal CMAJ in February 2020 describes five types of drug interactions possible with the use of cannabis. Cannabis is a plant-derived drug containing the psychoactive ingredient delta-9-tetrahydrocannabinol (THC) and non-psychoactive cannabidiol (CBD). These cannabinoids are broken down by the liver enzymes cytochrome P450 C(YP)34A, and CYP2CC9.

2 Mar 2020

Finding opens door to early identification of individuals at risk for delirium complications

Regenstrief Institute and Indiana University School of Medicine researchers have identified blood-based biomarkers associated with both delirium duration and severity in critically ill patients. This finding opens the door to easy, early identification of individuals at risk for longer delirium duration and higher delirium severity and could potentially lead to new treatments of this brain failure for which drugs have been shown to be largely ineffective.

22 Jan 2020

Protein SV2A levels could explain poor neuronal connections in schizophrenia

A team of researchers have found that persons with schizophrenia may have lower levels of certain specific proteins that show up on their brain scans. This could help as diagnostic tools, say experts. The new study titled, “Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats”, is published in the latest issue of the journal Nature Communications.

14 Jan 2020

New probe can identify and latch onto proteins on surface of endoplasmic reticulum

Sigma receptors are proteins found on mainly the surface of endoplasmic reticulum in certain cells. Sigma-1 and sigma-2 are the two main classes of these receptors.

20 Jun 2019

Researchers develop technique to track proteins on the surfaces of endoplasmic reticulum in cells

Researchers from Kanazawa University on the development of a technique to closely track a specific protein on the surfaces of endoplasmic reticulum (ER) in cells. Their findings are published in Bioorganic and Medicinal Chemistry.

17 Jun 2019

Case study: Cannabinoid hyperemesis syndrome in a patient with ALS

This case study of a patient with ALS and symptoms of cannabinoid hyperemesis syndrome emphasizes the need for research into the use of medicinal cannabis.

12 Jun 2019

Roundworm study suggests alternatives for treatment of schizophrenia

A group of Brazilian scientists have long conducted experiments with roundworms to investigate the role of schizophrenia-linked genes in patients' response to antipsychotic drugs. The results obtained thus far point to new ways of understanding resistance to certain classes of medication.

20 Mar 2019

Changing drugs, deprescribing do not lower severity and duration of delirium in ICU patients

The results of two new Regenstrief Institute trials published in the Journal of the American Geriatrics Society underscore and confirm the need to look to options other than medication to lower the duration or severity of delirium in intensive care unit patients.

6 Mar 2019

Study highlights need for personalized approach to treat ICU acquired delirium

A population heath study from the Regenstrief Institute and Indiana University Center for Aging Research has determined that halo, did not benefit elective thoracic surgery ICU patients when given prophylactically, with the possible exception of those who have had surgery to remove their esophagus.

14 Dec 2018

Researchers explore use of antipsychotic medications in older adults following heart surgery

Delirium is the medical term for an abrupt, rapid change in mental function that goes well beyond the typical forgetfulness of aging.

21 Aug 2018