Haloperidol Contraindications

NewsGuard 100/100 Score

Haloperidol is a traditional or conventional antipsychotic used to treat schizophrenia, mania and other forms of psychosis. It is a derivative of butyrophenone and it acts by blocking the effects of dopamine, a chemical in the brain that affects thinking, behavior and feelings.

However, there are several conditions for which the use of haloperidol is contraindicated. Some of these contraindications are absolute and the agent should not be used to treat patients with these conditions under any circumstances. Other contraindications are relative, meaning the drug may be used if the benefits outweigh the risks.

Absolute contraindications

  • Previous history of acute stroke or coma
  • Severe intoxication with alcohol or any other drug that acts as a central nervous system depressant
  • Allergy to haloperidol or other drugs of the butyrophene class
  • Heart disease

Relative contraindications

Special caution is advised in the presence of the following conditions:

  • Parkinson’s disease or dementia with Lewy bodies
  • Patients at risk of QT prolongation, a rare heart condition that increases the risk of arrhythmia originating in the ventricles
  • Impaired liver function (the metabolism of haloperidol is mainly hepatic)
  • In epileptic patients, haloperidol can reduce the threshold at which a convulsion may occur
  • The effects of haloperidol are stronger in patients with hyperthyroidism and there is an increased risk of side effects in this patient group
  • The intravenous administration of haloperidol injection can lead to postural hypotension and collapse

Further Reading

Last Updated: Feb 26, 2019

Dr. Ananya Mandal

Written by

Dr. Ananya Mandal

Dr. Ananya Mandal is a doctor by profession, lecturer by vocation and a medical writer by passion. She specialized in Clinical Pharmacology after her bachelor's (MBBS). For her, health communication is not just writing complicated reviews for professionals but making medical knowledge understandable and available to the general public as well.

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Mandal, Ananya. (2019, February 26). Haloperidol Contraindications. News-Medical. Retrieved on May 20, 2024 from https://www.news-medical.net/health/Haloperidol-Contraindications.aspx.

  • MLA

    Mandal, Ananya. "Haloperidol Contraindications". News-Medical. 20 May 2024. <https://www.news-medical.net/health/Haloperidol-Contraindications.aspx>.

  • Chicago

    Mandal, Ananya. "Haloperidol Contraindications". News-Medical. https://www.news-medical.net/health/Haloperidol-Contraindications.aspx. (accessed May 20, 2024).

  • Harvard

    Mandal, Ananya. 2019. Haloperidol Contraindications. News-Medical, viewed 20 May 2024, https://www.news-medical.net/health/Haloperidol-Contraindications.aspx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.