Heparin News and Research

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Heparin, a highly-sulfated glycosaminoglycan, is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule. It can also be used to form an inner anticoagulant surface on various experimental and medical devices such as test tubes and renal dialysis machines. Pharmaceutical grade heparin is derived from mucosal tissues of slaughtered meat animals such as porcine (pig) intestine or bovine (cow) lung.

Cost-effectiveness analysis of four interventions for treatment of cancer-associated thrombosis

A cost-effectiveness analysis comparing direct oral anticoagulants (DOACs) to low-molecular-weight heparin (LMWH) found that DOACs are both more medically effective and cost-effective than LMWH when treating cancer-associated thrombosis (CAT).

27 Dec 2022

Direct oral anticoagulants more effective and cost-effective for treating cancer-associated thrombosis

Research conducted by UC Davis Comprehensive Cancer Center and the University of Cincinnati shows that direct oral anti-coagulant (DOAC) drugs are more effective and are more cost-effective than low molecular weight heparin (LMWH) for treating cancer-associated thrombosis (CAT).

27 Dec 2022

What are the long-term outcomes of critical COVID-19 patients?

Researchers assessed the long-term outcomes of critically ill coronavirus disease 2019 (COVID-19) patients.

21 Dec 2022

Natural material derived from seaweed can help improve outcomes after heart bypass surgery

Researchers are using a natural material derived from seaweed to promote vascular cell growth, prevent blood clots and improve the performance of synthetic vascular grafts used in heart bypass surgery.

5 Dec 2022

Study suggests anti-PF4 antibodies may play a role in the severe multiorgan disease manifestations of COVID-19

Researchers investigated the association between the increased levels of anti-platelet factor 4 antibodies and the clinical complications of COVID-19.

7 Nov 2022

In mild cases of COVID, blood clot risk is higher

Researchers examine the association between COVID-19 and increased cardiovascular outcomes and mortality sequelae.

27 Oct 2022

Pathophysiological mechanisms of COVID-19-related endothelial dysfunction and potential therapies

Researchers discussed the pathophysiological mechanisms of endothelial dysfunction associated with severe coronavirus disease 2019 (COVID-19) and commented on the potential therapeutic strategies to treat endothelial damage and coagulopathy related to COVID-19.

19 Oct 2022

Study explores the effect of COVID-19 on platelet function

A new study posted in the pre-print server bioRxiv* aimed to analyze the impact of COVID-19 on platelet proteome and relate the functional responses of platelets and the formation of platelet-neutrophil aggregate in hospitalized COVID-19 patients.

17 Oct 2022

Multiple ischemic strokes and pulmonary embolism found in COVID-19 patient

In a new study, researchers described a case of a patient with acute respiratory failure and ischemic stroke.

17 Oct 2022

In silico studies identify potent plant metabolites capable of inhibiting SARS-CoV-2

In silico studies assess the binding efficacy of phytoconstituents against active sites of SARS-CoV-2.

16 Oct 2022

$Over-the-counter aspirin effective in preventing blood clots following surgery to repair bone fractures$

Over-the-counter aspirin effective in preventing blood clots following surgery to repair bone fractures

Patients who have surgery to repair bone fractures typically receive a type of injectable blood thinner, low-molecular-weight heparin, to prevent life-threatening blood clots, but a new clinical trial found that over-the-counter aspirin is just as effective.

14 Oct 2022

Oral anticoagulant drug may be safe, effective in preventing blood clots after urologic cancer surgery

The oral anticoagulant drug apixaban may offer a safer, more effective alternative to standard home heparin injections for patients taking extended prophylaxis (EP) to prevent blood-clot-related complications after surgery, reports a study in The Journal of Urology, an Official Journal of the American Urological Association.

12 Sep 2022

Immunosuppressive therapies for COVID-19 treatment

In a new study, researchers assessed the impact of baricitinib, netakimab, and tocilizumab against coronavirus disease 2019 (COVID-19).

31 Aug 2022

What is the association between polyfluoroalkyl substance exposure and risk of non-viral hepatocellular carcinoma?

The current study, published online in the journal JHEP Reports, looks at PFAS, which are endocrine disruptors and potential hepatotoxins.

11 Aug 2022

The recent progress in investigating the inhibitory impact of nanosponges and antiviral delivery against SARS-CoV-2

Researchers assessed the potential of nanosponges against SARS-CoV-2.

1 Aug 2022

Hospitalized COVID-19 patients with high blood viscosity have greater risk of death

Patients hospitalized with COVID-19 with high estimated blood viscosity are at higher risk of death from complications. High blood viscosity impairs flow to small vessels and increases the risk of blood clots. This measure of blood thickness can be used as a predictor of mortality.

18 Jul 2022

Prostaglandin E1 could enhance the safety of ECMO

In case of heart and/or lung failure, an ECMO machine can be used to maintain organ function for days or even weeks.

18 Jul 2022

Many treatments for intracerebral hemorrhage are not as effective as previously thought, guideline suggests

Some treatments or preventive therapies used to manage intracerebral hemorrhages (ICH), or a bleeding stroke, are not as effective as previously believed, according to the new American Heart Association/American Stroke Association guideline for caring for people with spontaneous ICH, published today in the Association's Stroke journal.

17 May 2022

Prevalence of low-molecular-weight heparin prescription in pregnant women according to level of venous thromboembolic disease risk

The present study was carried out to determine how often LMWH was prescribed in pregnancy, the risk classification of such women based on the ETV-OBS risk calculator, and how the risk varied with the occurrence of SARS-CoV-2 infection.

2 May 2022

Green tea catechin as pan-coronavirus attachment inhibitor

In a recent study posted to the Research Square* preprint server, researchers assessed the impact of green tea catechin epigallocatechin gallate (EGCG) on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

27 Apr 2022