Heparin News and Research

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Heparin, a highly-sulfated glycosaminoglycan, is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule. It can also be used to form an inner anticoagulant surface on various experimental and medical devices such as test tubes and renal dialysis machines. Pharmaceutical grade heparin is derived from mucosal tissues of slaughtered meat animals such as porcine (pig) intestine or bovine (cow) lung.

Direct oral anti-coagulants less likely to result in major bleeding after rare, fatal stroke

Direct oral anti-coagulant (anti-clotting) (DOAC) medications that target a single clotting factor work just as well to prevent future clots as the older, less-specific medication warfarin.

11 Feb 2022

Patients undergoing neurosurgical operations with concomitant COVID-19 infection have higher rates of perioperative complications

This unique paper compares neurosurgical patients with COVID-19 for perioperative complications to those without COVID-19.

31 Jan 2022

γ’ fibrinogen as a disease progression marker for COVID-19

Levels of the inflammatory biomarker gamma prime fibrinogen (γ' Fbg) varies according to severity in COVID-19 patients.

28 Jan 2022

Cell surface expression of SARS-CoV-2 nucleocapsid protein and its role in immunity

Researchers demonstrated the unexpected roles of nucleocapsid protein in innate and adaptive immunity to SARS-CoV-2.

15 Dec 2021

Thrombosis may increase mortality risk in hospitalized COVID-19 patients

A team of US-based scientists has recently explored various risk factors associated with the poor prognosis of coronavirus disease 2019 (COVID-19). They have identified thrombosis-related risk factors as a major predictor of in-hospital COVID-19 related mortality. The study is currently available on the medRxiv* preprint server while awaiting peer review.

14 Dec 2021

Study suggests algal polysaccharide may be a promising anti-COVID-19 candidate

Researchers from the Rensselaer Polytechnic Institute have been investigating the potential of rhamnan sulfate as an antiviral agent.

7 Dec 2021

Thrombosis with thrombocytopenia syndrome rare but serious adverse event associated with Ad26.COV2.S vaccination

A recent study conducted in the United States has revealed that thrombosis with thrombocytopenia syndrome following adenoviral vector-based coronavirus disease 2019 (COVID-19) vaccination is a rare event.

16 Nov 2021

Anti-platelet drug class fails to extend survival in moderately ill COVID-19 patients

A drug class that blocks the activity of blood platelets and prevents clotting—P2Y12 inhibitors—failed to extend survival or lessen disease severity in patients with COVID-19 who were hospitalized but had a relatively moderate case, a new study finds.

15 Nov 2021

COVID-19 drug candidate with wide-ranging antiviral activity

A new study investigated the antiviral activity and mechanism of action of Brilacidin against multiple human coronaviruses.

9 Nov 2021

Automated method shows predictive power for COVID-19 in-hospital mortality

Researchers focussed on the S-learner strategy of estimating the conditional average treatment effect.

4 Nov 2021

Therapeutic heparin for preventing COVID-19 deaths is four times higher than the prophylactic dose

The anti-coagulant heparin reduces the likelihood of death from COVID-19 by 78% when administered in therapeutic doses to patients with signs of respiratory failure on admission to hospital, according to a study reported on October 14 in the British Medical Journal.

30 Oct 2021

Suggested mechanism of SARS-CoV-2 infection inhibition by Mitoxantrone

A group of researchers performed a drug repurposing screen on an FDA-approved anti-cancer drug named Mitoxantrone.

20 Oct 2021

SARS-CoV-2 immune responses in nursing home residents after full vaccination with Pfizer-BioNTech COVID-19 vaccine

A new study assesses antibody and functional T-cell responses at 6 months after complete vaccination with the Pfizer-BioNTech vaccine.

11 Oct 2021

Characterization of circulating neutrophils from hospitalized COVID-19 patients

A new preprint deals with the characterization of neutrophil phenotypes in an attempt to provide biomarkers that can predict severe disease in patients hospitalized with COVID-19.

8 Oct 2021

Study outlines a baseline bundle of care interventions for critically ill patients

Critical illness results in millions of deaths globally every year, many of which could be avoided with basic, life-saving care. Now, a new study led by researchers at Karolinska Institutet in Sweden outlines a baseline bundle of care interventions that global experts agree should be available for all critically ill patients. The study, published in the journal BMJ Global Health, provides a blueprint for hospitals on how to reduce preventable deaths, including from COVID-19.

21 Sep 2021

Heparin News and Research

Further Reading

Direct oral anti-coagulants less likely to result in major bleeding after rare, fatal stroke

Patients undergoing neurosurgical operations with concomitant COVID-19 infection have higher rates of perioperative complications

γ’ fibrinogen as a disease progression marker for COVID-19

Cell surface expression of SARS-CoV-2 nucleocapsid protein and its role in immunity

Thrombosis may increase mortality risk in hospitalized COVID-19 patients

Study suggests algal polysaccharide may be a promising anti-COVID-19 candidate

Thrombosis with thrombocytopenia syndrome rare but serious adverse event associated with Ad26.COV2.S vaccination

Anti-platelet drug class fails to extend survival in moderately ill COVID-19 patients

COVID-19 drug candidate with wide-ranging antiviral activity

Automated method shows predictive power for COVID-19 in-hospital mortality

Therapeutic heparin for preventing COVID-19 deaths is four times higher than the prophylactic dose

Suggested mechanism of SARS-CoV-2 infection inhibition by Mitoxantrone

SARS-CoV-2 immune responses in nursing home residents after full vaccination with Pfizer-BioNTech COVID-19 vaccine

Characterization of circulating neutrophils from hospitalized COVID-19 patients

Study outlines a baseline bundle of care interventions for critically ill patients

Could monitoring headaches after COVID-19 vaccination help identify rare cases of cerebral venous thrombosis?

Evolved SARS-CoV-2 viruses gain higher infectivity and cause more rapid infection spread

Researchers focus on improving biomaterials used for bone and tissue repair

Assessing the risks of thrombotic events post vaccination with ChAdOx1 and BNT162b2 vaccines in England

Persistence of Anti-PF4 levels in VITT patients four months after AstraZeneca COVID-19 vaccine

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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