Herceptin News and Research

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Rogue messengers can negatively affect the body's immune system response against cancer

Researchers from Trinity College Dublin have made a discovery around treatment-resistant breast cancer that may turn the phrase, 'don't shoot the messenger', on its head. The scientists have found that cell to cell messengers released by cancer cells which are not responding to treatment, can negatively affect the body's immune system response against cancer.

28 Sep 2017

Adding a second HER2-targeted treatment may improve outcomes for some women with breast cancer

A phase III clinical trial of 4,805 women with HER2-positive breast cancer suggests adding a second HER2 targeted medicine, pertuzumab (Perjeta), to standard of care trastuzumab (Herceptin) after surgery may help, although the benefit is modest.

6 Jun 2017

Scientists identify biomarkers to predict patient’s response to breast cancer treatment

Why do some breast cancers respond to treatment while others resist it? A study led by researchers at the University of North Carolina Lineberger Comprehensive Cancer Center may provide insight into this important question.

8 Dec 2016

Brain metastasis persists in women with HER2-positive breast cancer despite new targeted therapies

While new targeted treatments developed across the past two decades have led to dramatic survival improvements for women with HER2-positive metastatic breast cancer, University of North Carolina Lineberger Comprehensive Cancer Center researchers and collaborators report that rates of breast cancer brain metastasis for women with this disease have not substantially declined.

7 Dec 2016

Study shows heart medications prevent cardiovascular damage during breast cancer treatment

Heart medication taken in combination with chemotherapy reduces the risk of serious cardiovascular damage in patients with early-stage breast cancer, according to results from a new landmark clinical trial.

29 Nov 2016

New NIST Standard Reference Material helps ensure accurate measurements of HER2 breast cancer gene

A new measurement standard developed by the National Institute of Standards of Technology has been used successfully by the Frederick National Laboratory for Cancer Research to check the performance of next-generation DNA-sequencing technologies for evaluating gene variations associated with an increased risk of breast cancer.

18 Aug 2016

Researchers uncover one way breast cancer tumors resist vital medication

A team of Case Western Reserve University School of Medicine cancer researchers has uncovered one way certain tumors resist vital medication.

11 Aug 2016

Updated guidelines for breast cancer increase number of patients who test HER2-positive

Changes to HER2 testing guidelines for breast cancer in 2013 significantly increased the number of patients who test HER2-positive, according to a new study by Mayo Clinic researchers published in the Journal of Clinical Oncology.

28 Jul 2016

Penn study provides more insights into cardiovascular side effects of breast cancer drug

A receptor protein that is the target of the breast cancer drug trastuzumab (Herceptin) is needed for proper heart blood-vessel development, reported researchers from the Perelman School of Medicine at the University of Pennsylvania.

14 Jul 2016

Imaging technique could help doctors identify patients who may benefit breast cancer treatment

Cancer Research UK scientists have used imaging techniques as a new way to identify patients who could benefit from certain breast cancer treatments, according to a study published in ONCOTARGET today, (Thursday).

8 Jul 2016

Scientists find new way to slow growth of triple negative breast cancer

CANCER RESEARCH UK scientists have found a new way to slow the growth of the most aggressive type of breast cancer, according to research published in the journal Oncogene today (Monday).

14 Jun 2016

First large-scale proteogenomic study helps pinpoint genes that drive breast cancer

Building on data from The Cancer Genome Atlas project, a multi-institutional team of scientists has completed the first large-scale "proteogenomic" study of breast cancer, linking DNA mutations to protein signaling and helping pinpoint the genes that drive cancer.

26 May 2016

Single breath-hold for more than five minutes could make targeted radiotherapy feasible

Researchers at the University of Birmingham working with clinical teams at University Hospitals Birmingham NHS Foundation Trust have successfully shown for the first time that breast cancer patients can be trained to achieve single prolonged breath holds of over five minutes, opening the door for targeted radiotherapy to be administered with just one dose in each daily session.

12 May 2016

Herceptin drugs for breast cancer linked with increased risk of congestive heart failure

Breast cancer patients undergoing treatment with trastuzumab-containing regimens should be monitored for heart damage regardless of age. This is among the findings of a new study from the Peter Munk Cardiac Centre, the Institute for Clinical Evaluative Sciences (ICES) and the Ted Rogers Centre for Heart Research, University Health Network.

20 Apr 2016

Study reveals low rates of targeted drug use among older black women with early-stage breast cancer

The advent of targeted drugs for a specific type of breast cancer - HER2 positive - has dramatically improved survival rates for women with the disease. But a study led by researchers at the University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center reveals low rates of use of a targeted drug among older women with early-stage breast cancer of this type, and even lower rates for older black women.

13 Apr 2016

Neo-Bioscore staging system adds HER2 status for precise prognostic stratification of breast cancer subtypes

A new breast cancer staging system developed by researchers at The University of Texas MD Anderson Cancer Center finds that incorporating tumor biology is a critical prognostic indicator for women who undergo neoadjuvant, or pre-surgical, therapy for breast cancer.

18 Mar 2016

Multi-gene test can help identify early breast cancer patients who can safely be spared chemotherapy

Researchers have shown for the first time that it is possible to use a multi-gene test to identify patients with early breast cancer who can be spared chemotherapy and who will still be alive and well five years after diagnosis.

11 Mar 2016

Delivering microRNAs in cancer treatment: an interview with Dr Conde and Prof Artzi

microRNAs (miRs) are small endogenous noncoding RNA molecules (20–23 nucleotides) derived from imperfectly paired hairpin RNA structures naturally encoded in the genome that act specifically as triggering molecules to control translational repression or mRNA degradation.

11 Mar 2016

New drug combination treatment makes breast cancer tumours disappear in just 11 days

Approximately a quarter of women with HER2 positive breast cancer, who were treated with a combination of the targeted drugs lapatinib and trastuzumab before surgery and chemotherapy, saw their tumours shrink significantly or even disappear, according to results from a clinical trial.

11 Mar 2016

Understanding role of ethnicity, age in breast cancer prognosis

Although breast cancer is somewhat more aggressive in South Asian and Black women than in White women, this is largely due to age differences between ethnic groups in the UK, according to new research.

10 Mar 2016

Herceptin News and Research

Rogue messengers can negatively affect the body's immune system response against cancer

Adding a second HER2-targeted treatment may improve outcomes for some women with breast cancer

Scientists identify biomarkers to predict patient’s response to breast cancer treatment

Brain metastasis persists in women with HER2-positive breast cancer despite new targeted therapies

Study shows heart medications prevent cardiovascular damage during breast cancer treatment

New NIST Standard Reference Material helps ensure accurate measurements of HER2 breast cancer gene

Researchers uncover one way breast cancer tumors resist vital medication

Updated guidelines for breast cancer increase number of patients who test HER2-positive

Penn study provides more insights into cardiovascular side effects of breast cancer drug

Imaging technique could help doctors identify patients who may benefit breast cancer treatment

Scientists find new way to slow growth of triple negative breast cancer

First large-scale proteogenomic study helps pinpoint genes that drive breast cancer

Single breath-hold for more than five minutes could make targeted radiotherapy feasible

Herceptin drugs for breast cancer linked with increased risk of congestive heart failure

Study reveals low rates of targeted drug use among older black women with early-stage breast cancer

Neo-Bioscore staging system adds HER2 status for precise prognostic stratification of breast cancer subtypes

Multi-gene test can help identify early breast cancer patients who can safely be spared chemotherapy

Delivering microRNAs in cancer treatment: an interview with Dr Conde and Prof Artzi

New drug combination treatment makes breast cancer tumours disappear in just 11 days

Understanding role of ethnicity, age in breast cancer prognosis

Arrayed CRISPR Screening for Revolutionizing Target Discovery

Innovations in baculovirus–insect cell expression systems

Compound Management and its Crucial Role in Early Pharmaceutical Research

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