Hippocampus News and Research

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The hippocampus is a part of the forebrain, located in the medial temporal lobe. It belongs to the limbic system and plays major roles in short term memory and spatial navigation. Humans and other mammals have two hippocampi, one in each side of the brain.

Geron collaborates to explore hESC-based product for Alzheimer’s disease

Geron Corporation today announced that it has entered into a collaboration jointly funded by Geron and a University of California Discovery Research and Training Grant to investigate the therapeutic potential of its human embryonic stem cell (hESC)-based product, GRNOPC1, for Alzheimer’s disease. The company is currently developing GRNOPC1 for the potential treatment of spinal cord injury.

27 Jan 2010

Study demonstrates BTG2 gene is crucial for neurogenesis and contextual memory function

The birth of new neurons, a process called neurogenesis, is continuously occurring in the brain, not only during development but also during adulthood within two specialized areas, the hippocampus and the subventricular zone.

21 Jan 2010

Tocotrienol form of vitamin E prevents neural cell death and rescues the brain after stroke injury

Blocking the function of an enzyme in the brain with a specific kind of vitamin E can prevent nerve cells from dying after a stroke, new research suggests.

12 Jan 2010

New genetic findings may lead to better interventional therapies for obsessive compulsive disorders

A collaboration between the University of Massachusetts Medical School, the Cummings School of Veterinary Medicine at Tufts University and the Broad Institute at the Massachusetts Institute of Technology has identified a genetic locus on canine chromosome 7 which coincides with an increased risk of obsessive compulsive disorder (OCD) susceptibility.

7 Jan 2010

Diffusion tensor imaging detects signs of Alzheimer's disease

A new type of brain scan, called diffusion tensor imaging (DTI), appears to be better at detecting whether a person with memory loss might have brain changes of Alzheimer's disease, according to a new study published in the January 6, 2010, online issue of Neurology®, the medical journal of the American Academy of Neurology.

7 Jan 2010

New study reveals choline plays a critical role in fetal brain development

If you're pregnant and looking for an excuse to eat bacon and eggs, now you've got one: a new research study published in the January 2010 print issue of the FASEB Journal (http://www.fasebj.org) by a team of University of North Carolina researchers shows that choline plays a critical role in helping fetal brains develop regions associated with memory. Choline is found in meats, including pork, as well as chicken eggs.

5 Jan 2010

Brain circuit that holds the memory discovered

Ben W. Strowbridge, PhD, associate professor of neuroscience and physiology/biophysics, and Phillip Larimer, PhD, a MD/PhD student in the neurosciences graduate program at Case Western Reserve University School of Medicine, are the first to create stimulus-specific sustained activity patterns in brain circuits maintained in vitro.

28 Dec 2009

Four commonly used chemotherapy drugs disrupt birth of new brain cells, shows study

Researchers have developed a novel animal model showing that four commonly used chemotherapy drugs disrupt the birth of new brain cells, and that the condition could be partially reversed with the growth factor IGF-1.

18 Dec 2009

Naurex' GLYX-13 demonstrates antidepressant-like and anxiolytic-like activity without CNS-related side effects

Naurex Inc., a new clinical stage company developing innovative treatments for depression and other CNS disorders based on its novel GFPA NMDA receptor modulators, today announced that data presented at a major medical meeting showed that its lead compound GLYX-13 demonstrated robust antidepressant-like and anxiolytic-like activity with no signs of the CNS-related side effects seen with other drugs targeting the NMDA receptor.

16 Dec 2009

Study may lead to more targeted research and treatment for memory disorders

The conversations neurons have as they form and recall memories have been decoded by Medical College of Georgia scientists.

16 Dec 2009

Higher leptin levels associated with lower incidence of AD and dementia

Persons with higher levels of leptin, a protein hormone produced by fat cells and involved in the regulation of appetite, may have an associated reduced incidence of Alzheimer disease and dementia, according to a study in the December 16 issue of JAMA.

16 Dec 2009

Varian Medical Systems introduces RapidArc radiotherapy technology in Finland

Cancer patients in Finland have gained access to more advanced treatments with the introduction of RapidArc® radiotherapy technology from Varian Medical Systems at the only private radiotherapy clinic in the Nordic region.

15 Dec 2009

Researchers discover enzyme activity behind sleep deprivation

There is hope for those who miss one night too many or whose children keep them up at night. The unwelcome effects of a bad night's sleep - forgetfulness, impaired mental performance - can be dealt with by reducing the concentration of an enzyme in the brain. These are the conclusions of research published by Rubicon-grant winner Robbert Havekes and colleagues in the 22 October issue of Nature.

14 Dec 2009

Cell transplants may yield new therapies for dementia patients

Nerve cells transplanted into brain-damaged rats helped them to fully recover their ability to learn and remember, probably by promoting nurturing, protective growth factors, according to a new study.

10 Dec 2009

Rats exposed to passive smoking become dependent on nicotine, reveals study

Rats passively exposed to tobacco smoke become dependent on nicotine, according to a new study by Dr. Adrie Bruijnzeel and colleagues from the University of Florida in the US. Their findings of how rats' brains respond to exposure to tobacco smoke have implications for the study of the effects of tobacco smoke on the human brain even from passive exposure to other smokers, and for future studies testing new treatments for tobacco addiction. Their work has just been published online in Springer's journal Psychopharmacology.

9 Dec 2009

Psychological trauma leaves a trail of damage in a child's brain, reveal scientists

Psychological trauma leaves a trail of damage in a child's brain, say scientists at the Stanford University School of Medicine and Lucile Packard Children's Hospital. Their new study gives the first direct evidence that children with symptoms of post-traumatic stress suffer poor function of the hippocampus, a brain structure that stores and retrieves memories. The research helps explain why traumatized children behave as they do and could improve treatments for these kids.

9 Dec 2009

Amino acids can improve cognitive function in patients with severe brain injuries

Neurology researchers have shown that feeding amino acids to brain-injured animals restores their cognitive abilities and may set the stage for the first effective treatment for cognitive impairments suffered by people with traumatic brain injuries.

8 Dec 2009

GIND scientists identify drug treatments that can normalize neuron development in AD

Scientists at the Gladstone Institute of Neurological Disease (GIND) have discovered that two main causes of AD amyloid-beta (Aβ) peptides and apolipoprotein E4 (apoE4) impair the growth of new neurons born in adult brains. What is more, they have identified drug treatments that can normalize the development of these cells even in the presence of Aβ or apoE4. The findings are described in two separate papers published in the current issue of Cell Stem Cell.

4 Dec 2009

New findings shake the foundations of Alzheimer's research

Alzheimer's disease is caused by the build-up of a brain peptide called amyloid-beta. That's why eliminating the protein has been the focus of almost all drug research pursuing a cure for the devastating neurodegenerative condition.

24 Nov 2009

Exposure to gas fumes can increase aggressive behavior

Outrageous prices may not be the only thing causing anger at the petrol pumps. A new study, published in the open access journal BMC Physiology, has shown that rats exposed to fumes from leaded and unleaded gasoline become more aggressive.

24 Nov 2009

Hippocampus News and Research

Further Reading

Geron collaborates to explore hESC-based product for Alzheimer’s disease

Study demonstrates BTG2 gene is crucial for neurogenesis and contextual memory function

Tocotrienol form of vitamin E prevents neural cell death and rescues the brain after stroke injury

New genetic findings may lead to better interventional therapies for obsessive compulsive disorders

Diffusion tensor imaging detects signs of Alzheimer's disease

New study reveals choline plays a critical role in fetal brain development

Brain circuit that holds the memory discovered

Four commonly used chemotherapy drugs disrupt birth of new brain cells, shows study

Naurex' GLYX-13 demonstrates antidepressant-like and anxiolytic-like activity without CNS-related side effects

Study may lead to more targeted research and treatment for memory disorders

Higher leptin levels associated with lower incidence of AD and dementia

Varian Medical Systems introduces RapidArc radiotherapy technology in Finland

Researchers discover enzyme activity behind sleep deprivation

Cell transplants may yield new therapies for dementia patients

Rats exposed to passive smoking become dependent on nicotine, reveals study

Psychological trauma leaves a trail of damage in a child's brain, reveal scientists

Amino acids can improve cognitive function in patients with severe brain injuries

GIND scientists identify drug treatments that can normalize neuron development in AD

New findings shake the foundations of Alzheimer's research

Exposure to gas fumes can increase aggressive behavior

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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