Human Leukocyte Antigen News and Research

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CD19 CAR NK cell therapy clinical trial shows encouraging results for hematologic cancers

According to results from a Phase I/IIa trial at The University of Texas MD Anderson Cancer Center, treatment with cord blood-derived chimeric antigen receptor natural killer (NK)-cell therapy targeting CD19 resulted in clinical responses in a majority of patients with relapsed or refractory non-Hodgkin's lymphoma and chronic lymphocytic leukemia, with no major toxicities observed.

6 Feb 2020

Discovery of new killer T-cell offers hope of a 'one-size-fits-all' cancer therapy

Researchers at Cardiff University have discovered a new type of killer T-cell that offers hope of a "one-size-fits-all" cancer therapy.

21 Jan 2020

Lab tests reveal that newly discovered T-cell can kill various types of cancer

Scientists have discovered a T-cell receptor that has proven effective in targeting a variety of cancers in mice and in human cells within the lab.

21 Jan 2020

How tuberculosis progresses: genetic factors play a major role

There are almost 1.8 billion people with tuberculosis bacilli in their body, but only about 5% to 15% develop overt infection, usually within 18 months of initial exposure. The reason behind this selective progression has been sought for decades by scientists from a variety of fields.

5 Sep 2019

Large-scale study maps the genetic underpinnings of early TB progression

While the vast majority of the 1.8 billion people infected with the TB bacterium never experience active disease, an estimated 5 to 15 percent do develop full-blown infections--roughly half of them within 18 months of exposure.

4 Sep 2019

New insight into the immune system may help doctors to better fight cancer

Your immune system's natural killer cells recognize and attack two major kinds of danger - cells infected by viruses and cells affected by cancer.

20 Aug 2019

Type 1 diabetes linked to gut microbiome and genetic factors

A new study has revealed that the gut microbiome of children with a high genetic risk of developing type 1 diabetes is markedly different from those who have a low risk of the condition.

20 Aug 2019

Genetic risk for autoimmunity may be linked to differences in gut microbiome

Children with increased genetic risk of type 1 diabetes have different gut microbiomes than those with low risk, a new study found.

20 Aug 2019

Genetic variations linked with persistence of immunity after routine childhood vaccination

A genome-wide search in thousands of children in the UK and Netherlands has revealed genetic variants associated with differing levels of protective antibodies produced after routine childhood immunizations.

12 Jun 2019

Long-awaited structure offers new insights into rejection of transplanted organs

Rejection of any kind is always hard to deal with, but when one's body rejects a precious organ transplant, the consequences can be devastating. Professor A. Vathsala, Co-director of the National University Centre for Organ Transplantation at the National University Hospital and Professor of Medicine, shared that between 30% to 40% of kidney transplants are lost over time to rejection.

15 Mar 2019

Researchers identify gene that increases risk of antibiotic reaction

Researchers at Vanderbilt University Medical Center and colleagues have identified a gene that increases the risk for a severe and potentially life-threatening reaction to the commonly prescribed antibiotic vancomycin.

11 Mar 2019

Using TGS technology to make the perfect match even better for stem cell transplant recipients

At Anthony Nolan we save the lives of people with blood cancers and blood disorders that need a stem cell transplant.

4 Mar 2019

Powerful immune molecule silences barrel to protect transplanted organs from rejection

A powerful immune molecule helps protect transplanted organs from rejection by putting a silencer on two other immune molecules that converge to take a direct shot at the organ, scientists report.

5 Feb 2019

Researchers harness immune system to reveal new clues to produce HIV vaccine

The immune system is the body's best defense in fighting diseases like HIV and cancer. Now, an international team of researchers is harnessing the immune system to reveal new clues that may help in efforts to produce an HIV vaccine.

4 Feb 2019

Big data opens door for characterizing immunity-related genome in Japanese population

Although different genes are distributed widely across chromosomes, many genes related to the immune system are clustered together on human chromosome 6, in a segment called the major histocompatibility complex (MHC) region.

29 Jan 2019

Acutely injured deceased-donor kidneys are suitable for transplant, study suggests

Organ procurement teams are sometimes leery of accepting kidneys from deceased donors with acute kidney injury, fearing they will harm the recipients. However, a national study chaired by a Johns Hopkins kidney specialist suggests these fears may be unfounded.

7 Dec 2018

Maryland researchers receive grant to study the brain-to-gut connection in schizophrenia

Researchers at the University of Maryland School of Medicine's Maryland Psychiatric Center and Institute for Genome Sciences, along with researchers at the University of Maryland School of Pharmacy, have been awarded a collaborative five-year $1.78 million grant to study the brain-to-gut connection in schizophrenia.

5 Dec 2018

Monash researchers provide insight into intricate peptide changes affecting immune system

Human leukocyte antigen molecules are a group of proteins that help the immune system identify foreign invaders such as viruses and bacteria and which impact a wide variety of clinical outcomes including infection and cancer.

8 Nov 2018

New clinical trial initiated on experimental vaccine to stop the spread of glioblastoma

Rush University Medical Center is part of a new clinical trial testing whether an experimental vaccine can help patients' immune systems stop the spread of glioblastoma -- an aggressive form of brain cancer with veryhttps://www.rush.edu/news/press-releases/rush-testing-new-brain-cancer-vaccine few current treatment options.

14 Sep 2018

New study provides important clues to developing more effective Ebola vaccines

Scientists conducting the first comprehensive study of key immune system cells-;collected from West African Ebola survivors that kill Ebola infected cells have made a surprising discovery that provides important clues to developing effective vaccines against the infection.

24 Jul 2018

Human Leukocyte Antigen News and Research

CD19 CAR NK cell therapy clinical trial shows encouraging results for hematologic cancers

Discovery of new killer T-cell offers hope of a 'one-size-fits-all' cancer therapy

Lab tests reveal that newly discovered T-cell can kill various types of cancer

How tuberculosis progresses: genetic factors play a major role

Large-scale study maps the genetic underpinnings of early TB progression

New insight into the immune system may help doctors to better fight cancer

Type 1 diabetes linked to gut microbiome and genetic factors

Genetic risk for autoimmunity may be linked to differences in gut microbiome

Genetic variations linked with persistence of immunity after routine childhood vaccination

Long-awaited structure offers new insights into rejection of transplanted organs

Researchers identify gene that increases risk of antibiotic reaction

Using TGS technology to make the perfect match even better for stem cell transplant recipients

Powerful immune molecule silences barrel to protect transplanted organs from rejection

Researchers harness immune system to reveal new clues to produce HIV vaccine

Big data opens door for characterizing immunity-related genome in Japanese population

Acutely injured deceased-donor kidneys are suitable for transplant, study suggests

Maryland researchers receive grant to study the brain-to-gut connection in schizophrenia

Monash researchers provide insight into intricate peptide changes affecting immune system

New clinical trial initiated on experimental vaccine to stop the spread of glioblastoma

New study provides important clues to developing more effective Ebola vaccines

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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