Hypersensitivity News and Research

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Hypersensitivity is an exaggerated response by the immune system to a drug or other substance.

PREACH-M trial: Lenzilumab may improve treatment response in chronic myelomonocytic leukemia

Humanigen, Inc.today extended previously reported results by presenting additional, statistically significant hematologic improvements and reductions in inflammatory markers from lenzilumab, its investigational drug, in a Phase 2/3 trial of treatment-naïve participants with chronic myelomonocytic leukemia and RAS-pathway mutations.

9 Jun 2023

Identify the underlying mechanism associated with the initiation of focal amplification in breast cancer

Identifying the underlying mechanism associated with the initiation of focal amplification in breast cancer.

19 May 2023

Pregnancy and oral health: Unveiling the risks and awareness for mothers-to-be

Study examines the impact of pregnancy on oral health, including increased risks of gum disease and tooth decay. It also investigates women's self-assessment of oral health, health literacy, and awareness of the oral health-pregnancy connection.

15 May 2023

Researchers show the effect of SARS-CoV-2 infection on somatosensory abnormalities in a hamster model

In a recent article published in the journal Science Immunology, researchers in the United States performed a longitudinal cohort study in a golden hamster model to investigate the sensory-altering mechanisms induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection compared to an influenza A virus (IAV).

11 May 2023

Study may provide new avenues for addressing somatosensory symptoms of long COVID

COVID-19, the disease resulting from SARS-CoV-2 infection, is associated with highly variable clinical outcomes that range from asymptomatic disease to death.

9 May 2023

Hay fever could be triggering other allergies, doctor reveals

Hay fever may be triggering an allergic reaction to foods such as fruits, vegetables, nuts and legumes, a doctor from a digital healthcare provider has revealed.

8 May 2023

Neuropathic pain study uncovers pathophysiological mechanism and promising therapeutic target

Neuropathic pain -; abnormal hypersensitivity to stimuli -; is associated with impaired quality of life and is often poorly managed. Estimates suggest that 3 percent to 17 percent of adults suffer from neuropathic pain, including a quarter of people with diabetes and a third of people with HIV.

5 May 2023

Neutrophils found to play a key role in fibromyalgia pain

Targeting neutrophil activity and interactions with sensory neurons may be a potential approach for treating fibromyalgia pain.

25 Apr 2023

How alcohol intake contributes to increased pain and hypersensitivity

Chronic alcohol consumption may make people more sensitive to pain through two different molecular mechanisms-;one driven by alcohol intake and one by alcohol withdrawal.

21 Apr 2023

Gene mutation capable of regulating pain discovered

Pain afflicts at least 1.5 billion people worldwide, and despite the availability of various painkilling drugs, not all forms of pain are treatable.

3 Mar 2023

Study reveals new clues to the underlying cause of FXS symptoms

In Fragile X syndrome (FXS), the most common cause of autism, sensory signals from the outside world are integrated differently, causing them to be underrepresented by cortical pyramidal neurons in the brain.

17 Feb 2023

β-damascone can function as an efficient modulator of dendritic cell-mediated functions

Dendritic cells (DCs) are important players of the immune system with important functions such as the identification of infectious pathogens, production of cytokines (chemical signalers of the immune system), presentation of antigens to activate T-cells, and more.

10 Feb 2023

A microbiota-driven mechanism underlies severity of leishmaniasis infection

In a recent study posed to the medRxiv* preprint server, researchers in Brazil and the United States investigated the probable impact of the skin microbiome microbiota on the outcomes of cutaneous leishmaniasis.

8 Feb 2023

Eczema in young individuals remains a substantial public health burden in most countries

New research published in Clinical & Experimental Allergy indicates that the burden related to eczema in young individuals is substantial in most countries.

8 Feb 2023

Autistic individuals experience pain at a higher intensity than general population, study finds

A new study has examined the pain perception among people with autism and found that they experience pain at a higher intensity than the general population and are less adaptable to the sensation.

29 Jan 2023

Study describes a mechanism associated with the production of neuropathic pain

Neuropathic pain is a type of chronic pain caused by damage to the nervous system due mainly to metabolic diseases such as diabetes and arthritis, or to the side effects of some kinds of chemotherapy.

10 Jan 2023

Acupuncture could be a safe and feasible management option for IBS-D

Researchers preliminarily evaluated the practicality of utilizing the United States (US) Food and Drug Administration (FDA)-advocated endpoints to assess the effectiveness of acupuncture in IBS-D (irritable bowel syndrome with diarrhea) management.

5 Jan 2023

Researchers develop a lateral flow test to reliably identify and quantify allergens in foods

A team from the Universitat Politècnica de València, the Universitat de València, and the Centro de Investigación Biomédica en Red sobre Enfermedades Raras has developed a lateral flow test that identifies and quantifies the level of allergens reliably in food with the help of a smartphone.

23 Dec 2022

Targeting Piezo2 could provide new avenue for treating chronic pain related to gastrointestinal disorders

Targeting a receptor responsible for our sense of touch and temperature, which researchers have now found to be present in our colon, could provide a new avenue for treating chronic pain associated with gastrointestinal disorders such as irritable bowel syndrome.