IP3 News and Research

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Exploring the potential utility of calcium channel inhibitors in SARS-CoV-2 infection

In a new study, researchers discuss the role of calcium signaling pathways as targets of inhibition in potential new antiviral therapeutic pathways for SARS-CoV-2.

20 Jan 2022

Neurokinin-1 receptor: a potential drug target for the treatment of COVID-19

An opinion article aims to provide evidence that SP could be the possible factor for initiating the cytokine storm during severe SARS-CoV-2 infection.

21 Sep 2021

Scientists identify cellular mechanism that shows promise in treating cancer

Fighting cancer often means employing a suite of techniques to target the tumor and prevent it from growing and spreading to other parts of the body.

22 Jul 2020

Scientists identify endogenous activator of sigma-1 receptors in human cells

Cells communicate through complex mechanisms that typically involve receptors and ligands that bind to them. Endogenous ligands, produced by the body, have been identified for the vast majority of cellular receptors, helping explain receptor existence and function. But in the case of sigma-1 receptors, which interact with a diverse array of psychoactive drugs, an endogenous ligand has remained elusive.

14 Jan 2019

Supercomputer simulations reveal potential therapeutic target in HIV-1 replication

HIV-1 replicates in ninja-like ways. The virus slips through the membrane of vital white blood cells. Inside, HIV-1 copies its genes and scavenges parts to build a protective bubble for its copies.

10 Aug 2018

Findings reveal how Ca2+ promotes endothelium-mediated feedback vasodilation in arterioles

Vasoconstriction must be balanced with vasodilation, particularly in the arterioles that supply tissues with blood.

5 Jul 2017

Atomic resolution structure of key molecule may contribute to drug discovery for devastating conditions

Culminating a nearly 10 year effort, researchers have determined the atomic resolution structure of a key molecule that translates signals from a cell's local environment into a language that the cell can understand and use.

18 Apr 2017

New study reveals IRBIT's role in facilitating apoptosis

Billions of cells in our bodies die every day in an important process called apoptosis. Now, researchers at the RIKEN Brain Science Institute have mapped out a sequence of events that are necessary for apoptosis to occur properly.

21 Dec 2016

ItpkB enzyme regulates stem cells function to prevent cancer, anemia

Stem cells can generate any type of cell in the body, but they are inactive most of the time--and for good reason. When stem cells become too active and divide too often, they risk acquiring cell damage and mutations.

24 Mar 2015

Hutchinson-Gilford Progeria Syndrome can be compared to normal aging, say scientists

In a new research study, scientists from Vision Genomics, LLC, Insilico Medicine, Inc., and Howard University showed that Hutchinson-Gilford Progeria Syndrome (HGPS or Progeria) is comparable to normal aging with respect to cellular signaling pathways, and that HGPS truly recapitulates the normal aging process.

28 Jan 2015

Artificial cells to devour undesirables: an interview with Dr. Takanari Inoue

If junk is not removed, pathological conditions can develop. For example, in one condition, the neutrophil count significantly decreases. Neutrophils remove pathogens and people with a reduced neutrophil count are more prone to infection, especially to rare bacteria that wouldn’t cause infection under normal conditions.

3 Sep 2014

Suppressing hyperactivity of calcium channels alleviates familial Alzheimer's disease

In 2008, researchers at the Perelman School of Medicine at the University of Pennsylvania showed that mutations in two proteins associated with familial Alzheimer's disease (FAD) disrupt the flow of calcium ions within neurons.

15 May 2014

Researchers discover two molecules that control liver glucose production

In their extraordinary quest to decode human metabolism, researchers at the Salk Institute for Biological Studies have discovered a pair of molecules that regulates the liver's production of glucose---- the simple sugar that is the source of energy in human cells and the central player in diabetes.

9 Apr 2012

Calcium transfer impacts fuel mechanism for normal cell metabolism

University of Pennsylvania School of Medicine researchers have described a previously unknown biological mechanism in cells that prevents them from cannibalizing themselves for fuel. The mechanism involves the fuel used by cells under normal conditions and relies on an ongoing transfer of calcium between two cell components via an ion channel. Without this transfer, cells start consuming themselves as a way of to get enough energy.

28 Jul 2010

IP3 News and Research

Exploring the potential utility of calcium channel inhibitors in SARS-CoV-2 infection

Neurokinin-1 receptor: a potential drug target for the treatment of COVID-19

Scientists identify cellular mechanism that shows promise in treating cancer

Scientists identify endogenous activator of sigma-1 receptors in human cells

Supercomputer simulations reveal potential therapeutic target in HIV-1 replication

Findings reveal how Ca2+ promotes endothelium-mediated feedback vasodilation in arterioles

Atomic resolution structure of key molecule may contribute to drug discovery for devastating conditions

New study reveals IRBIT's role in facilitating apoptosis

ItpkB enzyme regulates stem cells function to prevent cancer, anemia

Hutchinson-Gilford Progeria Syndrome can be compared to normal aging, say scientists

Artificial cells to devour undesirables: an interview with Dr. Takanari Inoue

Suppressing hyperactivity of calcium channels alleviates familial Alzheimer's disease

Researchers discover two molecules that control liver glucose production

Calcium transfer impacts fuel mechanism for normal cell metabolism

Lipid that accumulates in brain cells drives cell death, says research

Eavesdropping on cellular communication

Survival mechanism of T lymphocytes uncovered

New regulatory mechanism for critical protein signaling domain

Divergent behavioral roles of angiotensin receptor intracellular signaling cascades

Researchers find gene that is important for the control of fundamental rhythms in nematode worms

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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