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Research highlighting treatment for pediatric SCD, malaria presented at ASH 2010

Red blood cells have the very important role of carrying oxygen from the lungs to the rest of the body; therefore, disorders that affect RBCs can have a significant impact on quality of life. Sickle cell disease and malaria are two common RBC diseases that affect a significant portion of the U.S. and global populations. Sickle cell disease, a genetic blood disorder that causes deformed and dysfunctional red blood cells, affects an estimated 70,000 to 100,000 Americans, while malaria affects approximately 1,500 Americans annually and 190 to 311 million people worldwide.

6 Dec 2010

Alexion Pharmaceuticals reports interim results from phase 1 trial on samalizumab antibody

Alexion Pharmaceuticals, Inc. (Nasdaq: ALXN) today announced the presentation of interim results from the first Phase I/II trial of samalizumab, the company's investigational, first-in-class humanized monoclonal antibody.

6 Dec 2010

Study: REVLIMID and dexamethasone for high-risk smoldering multiple myeloma reduce risk of disease progression

Celgene International Sàrl (NASDAQ: CELG) announced that data evaluating combination therapy REVLIMID® (lenalidomide) and dexamethasone in patients with high-risk asymptomatic smoldering multiple myeloma were presented during the American Society of Hematology's annual meeting. The study reported REVLIMID and dexamethasone prolonged time to progression.

6 Dec 2010

Patients with H1N1 flu die due to over-reactive immune response: Research

On November 19, Jason Martin returned to the Medical Intensive Care Unit at Vanderbilt University Medical Center for the first time since he nearly died there during last year's H1N1 flu pandemic. The tall and burly Warren County, TN, ambulance worker - a 30-year-old, father of three young children - broke down and hugged some of the nurses he recognized.

6 Dec 2010

New studies answer questions related to stem cell transplant procedures in treating hematologic malignancies

Results from four innovative studies help answer outstanding questions about stem cell transplant procedures in treating various hematologic malignancies. Research that will be presented today at the 52nd Annual Meeting of the American Society of Hematology reveals that there is no increase in overall cancer risk in people who donate stem cells and that the utilization of a double cord blood stem cell transplant is associated with better overall outcomes when used early in the treatment of acute leukemias.

6 Dec 2010

Researchers adapt gene chip microarray technology to study glycans

Sugar molecules coat every cell in our bodies and play critical roles in development and disease, yet the components of these "glycans" have been difficult for scientists to study, because of their complexity.

6 Dec 2010

New drug for non-Hodgkin’s lymphoma shows promise

Genentech Inc., now part of Swiss drug developer Roche, and Biogen Idec Inc. on Sunday have announced positive and encouraging results from a clinical study of cancer drug Rituxan in patients with advanced type of non-Hodgkin’s lymphoma. An estimated 65,540 people in the US were diagnosed with non-Hodgkin's lymphoma this year, and follicular lymphoma accounts for about 15 to 20 percent of those cases. The disease can occur at any time during adulthood, though people are typically diagnosed during their 50s and 60s.

5 Dec 2010

Appropriate level of Static Magnetic Field exposure for wound patients needs to be considered

The interest in the biological effects of non-ionizing Electro Magnetic Fields (EMFs) and Static Magnetic Fields (SMFs) on the whole organism, as well on cellular systems, has noticeably increased in recent years in consideration of their increased production (from the generation and transmission of electricity, to domestic appliances and industrial equipment, to telecommunications and broadcasting) and the possible health risk for humans.

4 Dec 2010

Closer to restoring vision loss due to optic nerve damage

Damage to the optic nerve, connecting the eye with the brain, is a major cause of blindness. The most common culprit is glaucoma, estimated to affect more than 4 million Americans. There is currently no way to restore the lost vision, because the optic nerve, like other nerves in the mature central nervous system (CNS), cannot regenerate. Now, scientists at Children's Hospital Boston report achieving the greatest regeneration to date in the mammalian optic nerve.

4 Dec 2010

IDRI awarded $1.8M contract to develop adjuvant formulations for pandemic influenza

The Infectious Disease Research Institute has been awarded an $1.8 million contract from the Biomedical Advance Research and Development Authority. IDRI's work will focus on development of adjuvant formulations with options up to $8.5 million over three years when further development and manufacture of priority candidates are approved by the agency.

4 Dec 2010

IDRI receives $790,200 BARDA grant to develop pandemic flu vaccine

The Infectious Disease Research Institute (IDRI) today announced it has received a $790,200 grant from the Biomedical Advanced Research and Development Authority (BARDA), part of the US Department of Health and Human Services. The grant enables technology transfer between IDRI and the Cantacuzino National Institute of Research and Development for Microbiology and Immunology (Bucharest, Romania), with the goal of producing a pandemic flu vaccine.

4 Dec 2010

BRI enters 3-year partnership with Roche to develop human immunology programs

Baylor Research Institute (BRI), the research arm of Baylor Health Care System, announced that it has formed a three-year partnership with Roche to jointly develop programs emerging from the human immunology platforms developed at the Baylor Institute for Immunology Research (BIIR), a component of BRI.

4 Dec 2010

Gene mutation can lead to different mental illnesses when influenced by same environmental factor

Male mice born with a genetic mutation that's believed to make humans more susceptible to schizophrenia develop behaviors that mimic other major psychiatric illnesses when their mothers are exposed to an assault to the immune system while pregnant, according to new Johns Hopkins research.

4 Dec 2010

Mothers exposure to farm animals and cats during pregnancy lowers risk of atopic dermatitis in children

Children whose mothers are exposed to farm animals and cats are better protected against atopic dermatitis and are less likely to develop this painful inflammation of the skin in their first two years of life. A group of researchers from the University of Zurich and other universities have published evidence supporting this theory in the Journal of Allergy & Clinical Immunology.

3 Dec 2010

3M announces availability of TLR compounds for nonvaccine use in pharmaceutical industry

3M announces the availability of immune response modifier compounds for nonvaccine use in the pharmaceutical industry. The toll-like receptor (TLR) compounds, that activate through TLR7 and TLR8, show promise for the treatment of conditions including cancer, dermatologic diseases and atopic diseases, such as allergy and asthma.

3 Dec 2010

Trillium presents results from cancer stem cell program at ASH Annual Meeting

Trillium Therapeutics Inc. (TTI), a biopharmaceutical company developing innovative immune-based biologics, today announced that preliminary results from its cancer stem cell program, targeting the CD47 protein, will be reported in an oral presentation at the 52nd American Society of Hematology (ASH) Annual Meeting to be held in Orlando, Florida, December 4-7, 2010.

2 Dec 2010

Amgen to present data on Nplate studies for chronic ITP at ASH Annual Meeting

Amgen today announced that it will present data from several key Nplate (romiplostim) studies at the 52nd Annual Meeting and Exposition of the American Society of Hematology (ASH), Dec. 4-7, 2010, in Orlando, Fla.

2 Dec 2010

White House marks World AIDS Day

Commemorating World AIDS Day on Wednesday President Barack Obama called for continuing to fight HIV/AIDS domestically and abroad, Agence France-Presse reports (12/1).

2 Dec 2010

ROCHE, Baylor Research Institute partner in human immunology research

Baylor Research Institute (BRI), the research arm of Baylor Health Care System, announced today that it has formed a three-year partnership with Roche (SIX: RO, ROG; OTCQX: RHHBY) to jointly develop programs emerging from the human immunology platforms developed at the Baylor Institute for Immunology Research (BIIR), a component of BRI.

2 Dec 2010

Study on animal model may impact treatment of stroke

The results of two studies published in the current issue of Cell Transplantation (19:9) using animal models of cerebral ischemia and ischemic stroke in rats may significantly impact the treatment of stroke in humans.

2 Dec 2010

Immune System News and Research

Research highlighting treatment for pediatric SCD, malaria presented at ASH 2010

Alexion Pharmaceuticals reports interim results from phase 1 trial on samalizumab antibody

Study: REVLIMID and dexamethasone for high-risk smoldering multiple myeloma reduce risk of disease progression

Patients with H1N1 flu die due to over-reactive immune response: Research

New studies answer questions related to stem cell transplant procedures in treating hematologic malignancies

Researchers adapt gene chip microarray technology to study glycans

New drug for non-Hodgkin’s lymphoma shows promise

Appropriate level of Static Magnetic Field exposure for wound patients needs to be considered

Closer to restoring vision loss due to optic nerve damage

IDRI awarded $1.8M contract to develop adjuvant formulations for pandemic influenza

IDRI receives $790,200 BARDA grant to develop pandemic flu vaccine

BRI enters 3-year partnership with Roche to develop human immunology programs

Gene mutation can lead to different mental illnesses when influenced by same environmental factor

Mothers exposure to farm animals and cats during pregnancy lowers risk of atopic dermatitis in children

3M announces availability of TLR compounds for nonvaccine use in pharmaceutical industry

Trillium presents results from cancer stem cell program at ASH Annual Meeting

Amgen to present data on Nplate studies for chronic ITP at ASH Annual Meeting

White House marks World AIDS Day

ROCHE, Baylor Research Institute partner in human immunology research

Study on animal model may impact treatment of stroke

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