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Translational research results in promising combination therapeutic candidate for type 1 diabetes

Translational research led by scientists at La Jolla Institute for Immunology (LJI) has resulted in a promising combination therapeutic candidate for adults with recent-onset type 1 diabetes.

9 Mar 2021

Ultraviolet light therapy reduces viral load in critically ill COVID-19 patients

Scientists from the United States has recently evaluated the safety and efficacy profiles of ultraviolet-A (UVA) light applied via an endotracheal tube to critically ill COVID-19 patients.

9 Mar 2021

A SARS-CoV-2 spike protein adjuvant vaccine candidate produces durable rapid protection in vivo

A recent study reports the safety and high efficacy of an adjuvanted vaccine candidate against SARS-CoV-2 and the complications of COVID-19.

5 Mar 2021

Administering zinc supplements to Covid-19 patients may help reduce mortality and recovery time

Administering zinc supplements to Covid-19 patients with low levels of this element may be a strategy to reduce mortality and recovery time.

4 Mar 2021

Study: Bitter plant compound reduces inflammatory markers

Resveratrol is a plant compound found primarily in red grapes and Japanese knotweed. Its synthetic variant has been approved as a food ingredient in the EU since 2016.

3 Mar 2021

How SARS-CoV-2 proteins affect vascular functionality

The study, published on the pre-print server medRxiv, can pinpoint and isolate how each of the SARS-CoV-2 proteins independently affects the endothelial response and directly gauge endothelial functionality.

3 Mar 2021

Yale researchers identify multiple genes involved in suppression of axon regeneration

When central nervous system cells in the brain and spine are damaged by disease or injury, they fail to regenerate, limiting the body's ability to recover.

2 Mar 2021

Study shows asthma mediator IL-13 prevents SARS-CoV-2 infection

In a paper published on the bioRxiv preprint server, researchers reported the results on whether IL-13 expression in asthma patients reduces their susceptibility to SARS-CoV-2 infection.

1 Mar 2021

Study: Repurposed arthritis drug did not improve outcomes of patients with severe COVID-19 pneumonia

In a study published online February 25, 2021 in The New England Journal of Medicine, a repurposed drug used to treat arthritis did not significantly improve the outcomes of patients with severe COVID-19 pneumonia.

1 Mar 2021

SARS-CoV-2 modulates host cell central carbon metabolism for reproduction

A team of scientists from Sweden and India has recently characterized the host cell metabolic alterations associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Their findings reveal that SARS-CoV-2 modulates the host cell's central carbon metabolism to facilitate replication and infection propagation.

28 Feb 2021

Corticosteroid receptor inhibitor shows anti-SARS-CoV-2 activity in vivo

A team of researchers examined PT150, which is an allosteric modulator of androgen and glucocorticoid receptors, to assess whether it had any antiviral activity or immunomodulatory activity to decrease the hyperinflammatory response of SARS-CoV-2 infection.

24 Feb 2021

Scientists discover mechanism by which epithelial tumors cause maturation defects

Conducted on the fly Drosophila, the study shows that tumors caused by chromosomal instability delay entry into the adult phase.

23 Feb 2021

Study could lead to new strategies to prevent various cancers

Chronic inflammation drives the development of various cancers, including those of the skin, colon and pancreas. Investigators at Massachusetts General Hospital (MGH) who previously demonstrated high expression levels of an immune molecule called interleukin-33 (IL-33) during cancer-promoting inflammation have now uncovered the details behind the molecule's effects.

22 Feb 2021

COVID-19 and lung cancer have a common pathway, say researchers

A new preprint on the bioRxiv* server describes the common features COVID-19 shares with lung cancer.

19 Feb 2021

Endothelial SARS-CoV-2 infection induces proinflammatory responses without supporting viral amplification, finds study

A team of scientists from Australia and Brazil recently investigated the involvement of endothelial cells in the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

18 Feb 2021

New study sheds light on potential pathophysiological mechanism underlying delirium

Delirium, a common syndrome among older adults, particularly in those who have recently undergone surgery, critically ill patients in the ICU, and in older patients with multiple health issues, is a form of acute confusion that is characterized by poor attention, disorientation, impaired memory, delusions, and abrupt changes in mood and behavior.

17 Feb 2021

Immune system directly links personality to long-term mortality risk, study reveals

Ground-breaking research led by University of Limerick has revealed for the first time that the immune system directly links personality to long-term risk of death.

17 Feb 2021

Simulating an overactive autoimmune response leads to changes in the brain region

Researchers at the University of Tsukuba in Japan show that simulating an overactive autoimmune response in mice leads to changes in the hippocampal region of the brain.

17 Feb 2021

Study describes mechanism that limits immunosupressive activity of tumor-associated macrophages

Tumor cells are able to avoid the attack of the immune system through several mechanisms. For instance, these can secrete factors that turn macrophages -cells in the immune system- into dual action agents that contribute to the tumor progress and will protect it from immune body defenses: these become, thus, the tumor-associated macrophages (TAMs).

13 Feb 2021

Study sheds light on the recurrence of herpes simplex virus

Researchers at the University of Virginia School of Medicine have shed light on what causes herpes simplex virus to flare up, explaining how stress, illness and even sunburn can trigger unwanted outbreaks.

12 Feb 2021

Interleukin 5 News and Research

Translational research results in promising combination therapeutic candidate for type 1 diabetes

Ultraviolet light therapy reduces viral load in critically ill COVID-19 patients

A SARS-CoV-2 spike protein adjuvant vaccine candidate produces durable rapid protection in vivo

Administering zinc supplements to Covid-19 patients may help reduce mortality and recovery time

Study: Bitter plant compound reduces inflammatory markers

How SARS-CoV-2 proteins affect vascular functionality

Yale researchers identify multiple genes involved in suppression of axon regeneration

Study shows asthma mediator IL-13 prevents SARS-CoV-2 infection

Study: Repurposed arthritis drug did not improve outcomes of patients with severe COVID-19 pneumonia

SARS-CoV-2 modulates host cell central carbon metabolism for reproduction

Corticosteroid receptor inhibitor shows anti-SARS-CoV-2 activity in vivo

Scientists discover mechanism by which epithelial tumors cause maturation defects

Study could lead to new strategies to prevent various cancers

COVID-19 and lung cancer have a common pathway, say researchers

Endothelial SARS-CoV-2 infection induces proinflammatory responses without supporting viral amplification, finds study

New study sheds light on potential pathophysiological mechanism underlying delirium

Immune system directly links personality to long-term mortality risk, study reveals

Simulating an overactive autoimmune response leads to changes in the brain region

Study describes mechanism that limits immunosupressive activity of tumor-associated macrophages

Study sheds light on the recurrence of herpes simplex virus

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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