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Two MDC researchers win ERC funding worth several million euros

Basic researchers Gary Lewin and Norbert Hübner are investigating the molecular mechanisms underlying neurological and heart diseases. Their focus is on understanding the anchoring of ion channels and micropeptides in heart muscle cells.

13 Apr 2018

TradeShow Talks with Aurora Biomed

We're Aurora Biomed and we are attending Analytica so we can expand into new markets, mainly in Europe, and we're actually here looking for new distribution channels.

From Aurora Biomed Inc. 13 Apr 2018

Two new studies highlight GABA's importance in type 1 and type 2 diabetes

Dynamic interactions between the nervous system, hormones and the immune system are normally on-going but in diabetes the balance is disturbed.

5 Apr 2018

Study identifies potential genetic link in sudden infant death syndrome

Rare genetic mutations associated with impairment of the breathing muscles are more common in children who have died from sudden infant death syndrome (also known as ‘cot death’) than in healthy controls, suggesting a possible genetic element of the disorder, according to a case-control study in the UK and USA published in The Lancet.

29 Mar 2018

Researchers discover 'missing mutation' in severe infant epilepsy

Researchers have discovered a "missing mutation" in severe infant epilepsy--long-suspected genetic changes that might trigger overactive, brain-damaging electrical signaling leading to seizures.

20 Mar 2018

Researchers find the heart to be capable of arrhythmia termination after local gene therapy

The heart is capable of terminating arrhythmias itself after local gene therapy, potentially avoiding the need for patients to undergo painful electric shocks, according to a proof-of-concept study presented today at EHRA 2018, a European Society of Cardiology congress.

19 Mar 2018

Boosting the brain's immune cells may prevent or reduce severity of Alzheimer's disease

Sanford Burnham Prebys Medical Research Institute researchers have published two new studies in Neuron that describe how TREM2, a receptor found on immune cells in the brain, interacts with toxic amyloid beta proteins to restore neurological function.

8 Mar 2018

New discovery may allow doctors to treat inflammation in neurodegenerative diseases

A new discovery about the immune system may allow doctors to treat harmful inflammation that damages the brain in neurodegenerative diseases such as Alzheimer's. It might also let doctors save patients from the potentially deadly inflammation of sepsis, a full-body infection that kills a quarter-million Americans every year.

26 Feb 2018

Study reveals functional dynamics of ion channels

Most ion channels are very selective about the ions, which may or may not pass through them. They may be conductive for potassium ions and non-conductive for sodium ions or vice versa.

19 Feb 2018

Producing Super-Swelled Lyotropic Monocrystals for Drug Development

An interview with Dr. Cecília Leal, about a new method for producing bicontinuous cubic phases that are super-swollen and exist as monocrystals in solution.

15 Feb 2018

Study unravels developmental splicing program that promotes neuronal maturation

Neurons, or nerve cells, in the brain communicate with each other by transmitting electric signals, or firing action potentials, through long processes named axons (which send out signals) and dendrites (which receive signals).

1 Feb 2018

Findings provide better understanding of cell membrane components

Research conducted by Toyohashi University of Technology in collaboration with Tohoku University elucidated the fusion process of proteoliposomes with an artificial lipid bilayer and the mechanism behind this process.

1 Feb 2018

Researchers develop remote-controlled mechanogenetics system to target and kill cancer cells

A team of researchers has developed an ultrasound-based system that can non-invasively and remotely control genetic processes in live immune T cells so that they recognize and kill cancer cells.

15 Jan 2018

Researchers discover way to enhance effectiveness and safety of sonogenetics

Researchers at Duke University have discovered a way to enhance the effectiveness and safety of sonogenetics or ultrasonic modulation, emerging techniques that use sound waves to control the behavior of individual neurons or to promote tissue growth and wound healing in other cells.

3 Jan 2018

Researchers use Nobel prize-winning technology to zoom in and see vital kidney protein

Researchers have applied Nobel prize-winning microscope technology to uncover an ion channel structure that could lead to new treatments for kidney stones.

3 Jan 2018

Research clarifies role of zinc transport mechanism in onset of obstructive pulmonary diseases

Obstructive pulmonary disease is a collective term for refractory respiratory diseases with chronic airway inflammation and excessive mucus retention that are accompanied by airway obstruction.

28 Dec 2017

Scientists unravel structure of protein behind sense of touch

Scientists at The Scripps Research Institute have solved the mystery of the structure of Piezo1, a member of a family of proteins that convert physical stimuli such as touch or blood flow into chemical signals.

21 Dec 2017

New small-molecule drug restores brain function, memory in mouse model of Alzheimer's disease

An international team of researchers has shown that a new small-molecule drug can restore brain function and memory in a mouse model of Alzheimer's disease.

5 Dec 2017

Overcoming Challenges of Assays of Complex Cellular Models with Real-Time Live-Cell Analysis

There's a continued drive towards making in vitro assays ever more translational towards in vivo models and ultimately the clinic. This ties in with the resurgence of phenotypic screening and is a response to the perceived poor translation of the traditional simple cell-based assays, often developed to study just single protein targets.

From Sartorius 5 Dec 2017

Powerful digital model replicates biological activity that precedes sudden cardiac death

Some heart disease patients face a higher risk of sudden cardiac death, which can happen when an arrhythmia -- an irregular heartbeat-- disrupts the normal electrical activity in the heart and causes the organ to stop pumping.

29 Nov 2017