Leukocyte News and Research

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The possible immune-mediated mechanisms causing CNS alterations during and post-acute SARS-CoV-2 infection

In a recent review published in Immunity, researchers explored potential mechanisms of neuro-immune pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

22 Jun 2022

Even asymptomatic maternal COVID-19 can potentially cause pregnancy complications

A recent study published in the Cell Reports journal analyzed immune ecology at the placenta in mild or asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy.

22 Jun 2022

Clonal diversity impacts longevity of T cell reaction specific to SARS-CoV-2 epitope

A recent article under review at the Nature Portfolio journal and currently available on the Research Square* preprint server analyzed the factors influencing the durability of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epitope-specific T cell reaction.

21 Jun 2022

Trial of peptide-centered SARS-CoV-2 T-cell activator in B-cell deficient individuals

A recent phase 1/2 study under review at the Nature Portfolio journal and posted to the Research Square* preprint server demonstrated that a peptide-centered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) T-cell activator, CoVac-1, was efficient in B-cell deficient people.

6 Jun 2022

Brain motor and fear circuits orchestrate the immune response to acute stress

A new study explores how acute stressors affected mice in terms of their immune responses in specific regions of the brain.

2 Jun 2022

Study shows the SARS-CoV-2 accessory protein ORF7a inhibits HLA-I surface expression levels in human cells

Researchers identified a single viral gene product, the accessory factor ORF7a, facilitating SARS-CoV-2 immune evasion by downregulating the surface expression of MHC class I molecules.

1 Jun 2022

Sarbecovirus open reading frame 7a suppresses major histocompatibility complex-I antigen presentation

Researchers demonstrated the sarbecovirus open reading frame 7a (ORF7a)-induced hindrance of the antigen presentation by the major histocompatibility complex class I (MHC-I) in hosts.

30 May 2022

Study shows how stress has a major impact on the immune system's ability to fight infections

Acute stress can be detrimental to fighting off infection, especially COVID-19, and increases the chance of dying in mouse models.

30 May 2022

Immunogenicity predictions reveal SARS-CoV-2 CD8+ T-cell epitopes

In a recent study posted to the bioRxiv* pre-print server, researchers identified several new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epitopes displayed on human leukocyte antigens class I (HLA-I) molecules.

26 May 2022

After SARS-CoV-2 infection, anti-chemokine antibodies correlate with better outcomes

A recent study posted to the bioRxiv* preprint server illustrated that specific chemokine antibodies aid in recognizing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) convalescent individuals with a desirable disease course.

26 May 2022

ATLAS assay reveals SARS-CoV-2 variant T-cell responses

Researchers utilize the ATLAS screening assay to reveal the antigen response profiles of T-cells to different SARS-CoV-2 variants.

23 May 2022

Downregulation of MHC-I surface expression by SARS-CoV-2 accessory proteins

Researchers analyze the mechanisms by which two SARS-CoV-2 accessory proteins, ORF3a and ORF7a, can downregulate the expression of MHC-I.

19 May 2022

Triple BNT162b2 vaccination found to establish long-term T lymphocyte immunity among MDS and CLL patients

In a new study, researchers evaluated the BNT162b2 coronavirus disease 2019 mRNA vaccine (antigen)-specific immune response among myeloid dysplastic syndrome and chronic lymphocytic leukemia patients.

18 May 2022

A study of SARS-CoV-2-mRNA booster vaccinations in immunocompromised patients

In a recent study published in the journal Frontiers in Immunology, researchers assessed the immune responses induced by vaccination with the messenger ribonucleic acid (mRNA)-1273 vaccine or the BNT162b2 vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections among immunocompromised individuals.

17 May 2022

Diagnostic performance of monocyte distribution width and other leukocyte parameters for SARS-CoV-2 and influenza infection

Researchers used a novel diagnostic screen, monocyte distribution width for SARS-CoV-2 and influenza infection.

9 May 2022

Leukocyte News and Research

The possible immune-mediated mechanisms causing CNS alterations during and post-acute SARS-CoV-2 infection

Even asymptomatic maternal COVID-19 can potentially cause pregnancy complications

Clonal diversity impacts longevity of T cell reaction specific to SARS-CoV-2 epitope

Trial of peptide-centered SARS-CoV-2 T-cell activator in B-cell deficient individuals

Brain motor and fear circuits orchestrate the immune response to acute stress

Study shows the SARS-CoV-2 accessory protein ORF7a inhibits HLA-I surface expression levels in human cells

Sarbecovirus open reading frame 7a suppresses major histocompatibility complex-I antigen presentation

Study shows how stress has a major impact on the immune system's ability to fight infections

Immunogenicity predictions reveal SARS-CoV-2 CD8+ T-cell epitopes

After SARS-CoV-2 infection, anti-chemokine antibodies correlate with better outcomes

ATLAS assay reveals SARS-CoV-2 variant T-cell responses

Downregulation of MHC-I surface expression by SARS-CoV-2 accessory proteins

Triple BNT162b2 vaccination found to establish long-term T lymphocyte immunity among MDS and CLL patients

A study of SARS-CoV-2-mRNA booster vaccinations in immunocompromised patients

Diagnostic performance of monocyte distribution width and other leukocyte parameters for SARS-CoV-2 and influenza infection

SARS-CoV-2 variants are not evolving to escape from T cell-mediated immunity

Multi-omics identify COVID-19 severity predictors and prothrombotic signatures in patients with end-stage kidney disease

SARS-CoV-2-specific T cells are broader after vaccination than after infection

The impact of leronlimab on CCR5 surface cell levels during long COVID

Scientists show how T cells may help protect against severe COVID

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Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

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