Lewy Bodies News and Research

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Link found between genetic and environmental causes of Parkinson's disease

Scientists at the Whitehead Institute for Biomedical Research have found that a single gene, known as PARK9, protects cells from manganese toxicity and rescues neurons from over-expression of the protein alpha-synuclein.

3 Feb 2009

Discovery of potential important pathway for controlling cell loss and survival in Parkinson's disease

Neurologists have observed for decades that Lewy bodies, clumps of aggregated proteins inside cells, appear in the brains of patients with Parkinson's disease and other neurodegenerative diseases.

1 Jan 2009

Researchers reduce production of alpha-synuclein in the brain - offers hope for Parkinson's disease

Mayo Clinic researchers have developed a method to reduce the production of alpha-synuclein in the brain.

17 Nov 2008

Transplanted dopamine neurons are affected by the Parkinson's disease process

A new groundbreaking study published in Nature Medicine has implications for the future of transplantation and stem cell therapies as a treatment for Parkinson's disease.

7 Apr 2008

Significant dementia risk attributable to small blood vessel damage

Autopsy data of 221 men and women found that the brains of one-third of individuals who had dementia before death showed evidence of small, cumulative blood vessel damage that can arise from hypertension or diabetes.

7 Apr 2008

1/3 of risk for dementia attributable to small vessel disease, autopsy study shows

Alzheimer's disease may be what most people fear as they grow older, but autopsy data from a long-range study of 3,400 men and women in the Seattle region found that the brains of a third of those who had become demented before death showed evidence of small vessel damage: the type of small, cumulative injury that can come from hypertension or diabetes.

7 Apr 2008

Smell impairment can precede the development of Parkinson's disease in men

Impaired sense of smell occurs in the earliest stages of Parkinson's disease (PD) and there is mounting evidence that it may precede motor symptoms by several years, although no large-scale studies had confirmed this.

24 Mar 2008

New insight into the fundamentals of Parkinson's disease

A single change in a protein may play a role in whether someone develops Parkinson's disease, say University of Florida Genetics Institute researchers writing in a recent issue of the Proceedings of the National Academy of Sciences.

27 Feb 2008

Research to look at reasons for the formation of Lewy bodies

A University of Nottingham researcher has been awarded more than £440,000 by the Parkinson’s Disease Society (PDS) to investigate the causes of the condition.

23 Jul 2007

Personality test could help doctors detect dementia with Lewy bodies

The study found that even before diagnosis, people with dementia with Lewy bodies displayed passive personality changes, such as diminished emotional response, disinterest in hobbies, repetitive behaviors, and growing apathy, or lack of interest, more often than those with Alzheimer's.

30 May 2007

Link between extreme sleep disorder and onset of parkinsonism or dementia

Mayo Clinic researchers and a group of international collaborators have discovered a correlation between an extreme form of sleep disorder and eventual onset of parkinsonism or dementia.

17 May 2007

New genetic model for Parkinson's disease

Researchers at the Karolinska Institute in Sweden are homing in on mechanisms that may explain one set of causes for Parkinson's disease.

1 Aug 2006

New genetic clues to dementia with Lewy bodies

Researchers have found that genetic alterations originally identified in people suffering from a rare disease may also be an important risk factor for the second most common form of dementia among the elderly.

17 Jul 2006

MRI study shows way to prevent development of degenerative brain diseases

A magnetic resonance imaging (MRI) study at UCLA opens new doors to assessing and potentially preventing brain iron accumulation associated with risk of developing degenerative brain diseases such as Alzheimer's, Parkinson's and Dementia With Lewy Bodies.

27 Mar 2006

Gene therapy to turn off Parkinson's

A group of Northwestern University researchers is developing a novel gene therapy aimed at selectively turning off one of the genes involved in the development of Parkinson's disease.

23 Jan 2006

Protein alpha-synuclein associated with causing neurodegenerative conditions may actually protects against neurodegeneration

Researchers at UT Southwestern Medical Center have discovered that a protein associated with causing neurodegenerative conditions may, when appearing in normal amounts, actually protects against neurodegeneration.

7 Nov 2005

First demonstration of a vaccine for Parkinson's

Researchers at the University of California, San Diego (UCSD) School of Medicine working with scientists at Elan Pharmaceuticals, have reported promising results in mice of a vaccine approach to treating Parkinson’s and similar diseases. These results appear in the June edition of the journal Neuron.

15 Jun 2005

A protein found naturally in the brain may protect against Parkinson's disease

The findings also may lead to an improved understanding of a disorder called early-onset torsion dystonia.

2 Jun 2005

Rifampicin can prevent the formation of protein fibrils associated with Parkinson's disease

Researchers at the University of California, Santa Cruz, have shown that rifampicin, an antibiotic used to treat leprosy and tuberculosis, can prevent the formation of protein fibrils associated with the death of brain cells in people with Parkinson's disease. The drug also dissolved existing fibrils in laboratory tests.

29 Nov 2004

Duplication of the alpha-synuclein gene causes Parkinson's disease in a French family

In affected individuals, age of onset, symptoms and symptom progression are similar to that observed in people with sporadic or unexplained cases of Parkinson's disease.

27 Sep 2004