Liver News and Research

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Fatty liver disease and body shape

For years, pear-shaped people who carry weight in the thighs and backside have been told they are at lower risk for high blood pressure and heart disease than apple-shaped people who carry fat in the abdomen.

5 Dec 2008

Low-dose peginterferon used for hepatitis C doesn't work

An NIH funded multi-center clinical trial found no benefit from "maintenance therapy," low-dose peginterferon used for hepatitis C patients who have not responded to an initial round of treatment.

3 Dec 2008

Scientists film immune cell becoming infected by a parasite

Forget what's number one at the box office this week. The most exciting new film features the intricate workings of the body, filmed by scientists using ground-breaking technology.

3 Dec 2008

Gene therapy used to alleviate sickle cell disease pathology

Using a harmless virus to insert a corrective gene into mouse blood cells, scientists at St. Jude Children's Research Hospital have alleviated sickle cell disease pathology.

3 Dec 2008

New evidence shows that the heart beats to its own drummer

They've uncovered some of the molecular circuitry within the cardiovascular system itself that controls the daily rise and fall of blood pressure and heart rate. The findings might also explain why commonly used diabetes drugs come with cardiovascular benefits, according to the researchers.

3 Dec 2008

Adropin protein produced by the liver sends signal that fat is on the way in response to high-fat foods

After you eat a burger and fries or other fat-filled meal, a protein produced by the liver may send a signal that fat is on the way, suggests a report in the December issue of the journal Cell Metabolism , a Cell Press publication.

3 Dec 2008

Horizon Therapeutics announces HZT-501 trials meet primary endpoints

Horizon Therapeutics, Inc. has announced that two pivotal Phase 3 trials evaluating its lead investigational product candidate, HZT 501, met all primary endpoints.

3 Dec 2008

Chemical used in antifouling paints may promote obesity

Tributyltin, a ubiquitous pollutant that has a potent effect on gene activity, could be promoting obesity, according to an article in the December issue of BioScience.

1 Dec 2008

Scientists discover new properties of imidazolium salts

Scientists at Singapore's Institute of Bioengineering and Nanotechnology (IBN) have uncovered new properties of imidazolium salts (IMSs), which suggest that they could play a vital role in disease prevention and treatment.

1 Dec 2008

Etanercept found to be ineffective in treating alcoholic hepatitis

A new study from Mayo Clinic finds the use of the drug therapy etanercept ineffective in treating alcoholic hepatitis, an acute inflammation of the liver caused by excessive consumption of alcohol. The results of the study are published in the December issue of Gastroenterology.

1 Dec 2008

Vitamin D deficiency could lead to heart problems

Vitamin D deficiency - which is traditionally associated with bone and muscle weakness - may also increase the risk of cardiovascular disease (CVD).

1 Dec 2008

New cream for vaginal dryness approved

Barr Pharmaceuticals, Inc. has announced that the U.S. Food and Drug Administration (FDA) has approved its subsidiary Duramed Pharmaceuticals, Inc.'s New Drug Application (NDA) for Synthetic Conjugated Estrogens-A (SCE-A) 0.625 mg/g Vaginal Cream.

1 Dec 2008

EGFR inhibitors show promise for obesity

Once-promising drugs that were abandoned in the fight against breast cancer still could be effective in obese patients, new research suggests.

1 Dec 2008

Bariatric surgery may resolve liver disease

Obesity is a growing epidemic in the U.S. with a significant increase in prevalence from 15 percent to 32.9 percent from 1980 to 2004. Nonalcoholic fatty liver disease (NAFLD) is an emerging problem related to the obesity epidemic, becoming one of the most common causes of liver disease in the nation.

1 Dec 2008

Antibiotics causing most drug-induced liver injury

Antibiotics are the single largest class of agents that cause idiosyncratic drug-induced liver injury (DILI), reports a new study in Gastroenterology, an official journal of the American Gastroenterological Association (AGA) Institute.

1 Dec 2008

Anadys Pharmaceuticals receives fast track for ANA598 treatment of chronic hepatitis C virus

Anadys Pharmaceuticals, Inc. has announced that the U.S. Food and Drug Administration (FDA) has granted fast track designation to ANA598 for the treatment of chronic hepatitis C virus (HCV) infection. ANA598 is Anadys' investigational hepatitis C non-nucleoside polymerase inhibitor.

1 Dec 2008

Early alcohol use leads to tolerance to high doses of alcohol later in life

A Baylor University study has found that exposure during adolescence to moderate doses of alcohol in a binge-like fashion does in fact produce tolerance to high doses of alcohol later in life.

1 Dec 2008

Scientists hope European grant can improve healthy ageing

Researchers hope to achieve healthy ageing by enhancing body healing capacity and reducing chronic inflammation.

1 Dec 2008

Liver disease tackled with dedicated unit at Imperial College London

Liver disease death rates are rising in the UK, in contrast to other common diseases such as heart disease and cancer, and the new Robert Hesketh Hepatology Clinical Research Facility aims to provide care and develop new therapies to reverse this trend.

1 Dec 2008

Eli Lilly withdraws application for additional U.S. indication for Cymbalta for chronic pain

Eli Lilly and Company has withdrawn its supplemental New Drug Application (sNDA) from the U.S. Food and Drug Administration (FDA) for Cymbalta (duloxetine HCl) for the management of chronic pain.

30 Nov 2008