Lungs News and Research

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Discovery may lead to new treatments for lung cancer and blood cancer

The research team uses a genetically modified mouse that produces a muted and constantly active CAAX protein. This is a new model for an extremely aggressive lung cancer and a mild form of blood cancer. In these mice, the production of an enzyme called GGTas1 can also be stopped.

8 May 2007

MR spectroscopy of choline levels shows promise as a marker of fetal lung maturity

The researchers performed high resolution MRS on 15 amniotic fluid samples for evaluation of fetal lung maturity between 34 and 40 weeks gestation and were analyzed using trimethysilylpropionic acid (TSP) as a reference standard.

8 May 2007

New evidence-based guidelines for patients with chronic obstructive pulmonary disease

New evidence-based guidelines from the American College of Chest Physicians (ACCP) and the American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR) recommend a comprehensive pulmonary rehabilitation program for patients with chronic obstructive pulmonary disease (COPD), citing that pulmonary rehabilitation can help improve a patient's exercise tolerance, dyspnea, and health-related quality of life, as well as decrease hospital stay and health-care utilization.

8 May 2007

Diabetes drug rosiglitazone boosts power of platinum chemotherapy

A widely used diabetes drug dramatically boosted the potency of platinum-based cancer drugs when administered together to a variety of cancer cell lines and to mice with tumors, scientists from Dana-Farber Cancer Institute report.

8 May 2007

How inhaled anthrax paralyzes the body's defenses

University of Florida researchers have revealed how the inhaled form of anthrax paralyzes the body's defenses and prevents immune cells from reaching the site of infection.

8 May 2007

Facts about rheumatoid arthritis and aging

For the better part of three decades, Sherrie Kossoudji has endeavored each day to manage the inflammation, chronic pain, tight joints and other types of physical strife caused by rheumatoid arthritis.

8 May 2007

Statins may reduce the risk of lung cancer even for smokers

New research in the U.S. is indicating that cholesterol-lowering statin drugs may protect against the development of lung cancer.

8 May 2007

Tens of thousands of Americans die each year from secondhand tobacco smoke

While the health risks associated with indoor secondhand smoke are well documented, little research has been done on exposure to toxic tobacco fumes outdoors.

4 May 2007

Study shows effectiveness of Peramivir in mouse model of H5N1 virus infection

BioCryst Pharmaceuticals has announced that investigators at St. Jude Children's Research Hospital, Memphis, TN, reported favorable results evaluating peramivir treatment in an animal model of influenza using a highly virulent strain of H5N1 virus (an avian influenza strain that had caused fatal human infection in Viet Nam).

4 May 2007

FDA issues "Critical Path Opportunities for Generic Drugs"

The U.S. Food and Drug Administration (FDA) today issued the "Critical Path Opportunities for Generic Drugs" report identifying many of the unanswered scientific questions that impede the development of generic versions of commonly used drugs.

4 May 2007

FDA approves new indication for FRAGMIN for the extended treatment of symptomatic venous thromboembolism

The U.S. Food and Drug Administration (FDA) has approved a new indication for FRAGMIN (dalteparin sodium injection), for the extended treatment of symptomatic venous thromboembolism (VTE) to reduce the recurrence of VTE in patients with cancer.

4 May 2007

Serious illness among children with sickle cell disease reduced with pneumococcal conjugate vaccine

A vaccine introduced in 2000 has reduced by more than 90 percent the rate of a serious bacterial illness among young children with sickle cell disease (SCD), who are particularly susceptible to it, according to a new study that appears in the June 1 issue of Clinical Infectious Diseases and currently is available online.

2 May 2007

Infliximab fails to improve chronic obstructive pulmonary disease symptoms

A promising anti-inflammatory drug failed to improve symptoms of moderate to severe chronic obstructive pulmonary disease, or COPD, in a large, multi-center trial.

2 May 2007

Peramivir shows promise for H5N1 protection

The antiviral drug peramivir might offer humans significant protection during a pandemic of the avian influenza virus H5N1, according to results of mouse studies conducted by investigators at St. Jude Children's Research Hospital.

2 May 2007

New treatments have major impact on heart failure rates

Deaths from severe heart attacks following admission to hospital have nearly halved in six years as a result of advances in medical treatment.

2 May 2007

New tool refines heart risk prediction

For about 10 years, the Framingham risk score has been used to estimate a person's chances of having a heart attack based on just six bits of information -- age, sex, total cholesterol, HDL cholesterol, smoking status, and systolic blood pressure.

2 May 2007

Adverse health outcomes after Hurricane Katrina among children and adolescents with chronic conditions

Children and teenagers in New Orleans with chronic medical conditions at the time of Hurricane Katrina were more likely than other children to have worsening of physical and psychological symptoms, develop new symptoms, miss doctor appointments and run out of medications in the wake of the disaster.

2 May 2007

Biomarker discovery bodes well for better cancer diagnostics

While new findings from Ohio State University scientists suggest a genetic marker that could help distinguish between chronic pancreatitis and pancreatic cancer and gauge who will do well with cancer treatment, a pharmacologist at the Kimmel Cancer Center at Jefferson in Philadelphia sees the discovery as much more.

2 May 2007

FDA advisory committee supports Advair 500/50 in reducing COPD exacerbations

An Advisory Committee to the Food and Drug Administration (FDA) has unanimously agreed that GlaxoSmithKline's Advair Diskus 500/50 (fluticasone propionate and salmeterol inhalation powder) demonstrated a significant reduction in the risk of exacerbations in patients with chronic obstructive pulmonary disease (COPD), the fourth leading cause of death in the U.S.

2 May 2007

Evidence of very early onset defective bone mineralization in the lumbar spine revealed in children with cystic fibrosis

In a study of children with cystic fibrosis, French researchers found evidence of very early onset defective bone mineralization in the lumbar spine that was not caused by either nutritional status or lung disease.

2 May 2007