Lymph Node News and Research

RSS

Lymph is clear or white fluid that travels through vessels, moves within tissues and work to keep all the parts of the body clean. After passing through the channels of the lymphatic system they drain into the lymph nodes. The lymph nodes act as filters along the lymphatic system. These nodes trap germs like bacteria, viruses, toxins as well as cancer cells and ensure that these are removed from the body.

Researchers uncover why typically normal protein drives prostate cancer

NSD-2 is crucial for AR activity in prostate cancer, promoting tumor growth and offering a potential therapeutic target for advanced prostate cancer treatment.

12 Sep 2024

Study finds early pancreatic cancer staging often inaccurate

Staging of patients with early pancreatic cancer is inaccurate as much as 80% of the time, according to a new Cedars-Sinai Cancer study published in the peer-reviewed journal JAMA.

5 Sep 2024

A novel therapeutic option for HER2-positive extramammary Paget disease

The research article presents a comprehensive evaluation of the human epidermal growth factor receptor 2 (HER2) status in extramammary Paget disease (EMPD) and explores the therapeutic potential of disitamab vedotin (DV), a novel humanized anti-HER2 antibody-drug conjugate (ADC), for this rare adenocarcinoma.

4 Sep 2024

New $5.8 million grant aims to transform the global landscape of TB research

A $5.8 million grant led by Adrie Steyn, Ph.D., of the University of Alabama at Birmingham and the Africa Health Research Institute, or AHRI, in Durban, South Africa, will provide user-requested infected human lung tissue and analytical services to tuberculosis researchers worldwide.

23 Aug 2024

Weill Cornell Medicine secures $12.4 million grant for lymphoma research

Weill Cornell Medicine has received a five-year, $12.4 million grant from the National Cancer Institute, part of the National Institutes of Health, for an extensive program of basic and translational research on the biology of diffuse large B-cell lymphoma (DLBCL), the most common form of lymphoma.

15 Aug 2024

Personalized treatment strategies based on calcification status in breast cancer

Mammographic calcifications, a common feature of breast cancer, have remained enigmatic in terms of their molecular underpinnings and clinical implications, particularly in the hormone receptor-positive, HER2-negative subtype.

13 Aug 2024

New insights into the role of cancer-associated fibroblasts in promoting lymphatic metastasis

Lymph node metastasis is a crucial factor in cancer progression, significantly affecting patient prognosis and treatment outcomes.

8 Aug 2024

Loss of Gα13 in B-cells linked to increased lymphoma risk due to dietary glutamine

Researchers find that the deletion of Gα13 in B-cells increases lymphoma risk by enhancing proliferation in gut-associated lymph nodes. Dietary glutamine significantly promotes these effects, highlighting a crucial link between diet and cancer.

29 Jul 2024

Antibody-drug conjugate effective, less toxic for stage 1 HER2+ breast cancer

A year of treatment with a medicine made of an antibody and chemotherapy drug has proven highly effective in preventing stage 1 HER2-positive breast cancer from recurring in patients, a team led by Dana-Farber Cancer Institute researchers has found.

28 Jun 2024

PFDN6 protein could be a new target for colorectal cancer treatment

Researchers have identified a protein called PFDN6 that may play a role in the development and spread of colorectal cancer (CRC).

27 Jun 2024

Open-source platform enables high-definition spatial transcriptomics

An open-source platform developed by researchers in Nikolaus Rajewsky's lab at the Max Delbrück Center creates molecular maps from patient tissue samples with subcellular precision, enabling detailed study and potentially enhancing routine clinical pathology. The study was published in "Cell."

25 Jun 2024

Enhancing CAR-T cell therapy with biodegradable scaffolds

CAR-T cell therapies are transforming the treatment of previously incurable blood cancers. Six approved CAR-T products have been administered to more than 20,000 people, and more than 500 clinical trials are underway.

12 Jun 2024

Innovative FAP-targeted radioligand therapy controls disease progression in sarcoma

Fibroblast activation protein (FAP)-targeted radioligand therapy is safe and effective for treating patients with progressive metastatic tumors, specifically advanced sarcomas, according to research presented at the 2024 Society of Nuclear Medicine and Molecular Imaging Annual Meeting.

10 Jun 2024

‘Artificial lymph node’ shows potential to treat cancer

Johns Hopkins Medicine scientists say they have developed an artificial lymph node with the potential to treat cancer, according to a new study in mice and human cells.

6 Jun 2024

Novel PET radiotracer enables same-day imaging of gastrointestinal cancer biomarker

A new PET radiotracer enables same-day imaging of the important gastrointestinal cancer biomarker known as Claudin18.2 (CLDN18.2).

6 Jun 2024

New treatment approach could offer longer lasting protection to people with breast cancer

Killing breast cancer cells in a way that trains the immune system to recognize and destroy residual cancer cells could offer longer lasting protection to people with the disease, according to new research funded by Breast Cancer Now.

3 Jun 2024

New study advocates for de-escalating breast cancer surgery in women aged 55 and older

Surgery involving sentinel lymph node biopsy for middle-aged women with estrogen receptor-positive (ER+) breast cancer may do more harm than good, according to a new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers.

22 May 2024

Oncotype DX Breast Recurrence Score test recommended by NICE for lymph node-positive breast cancer patients

Exact Sciences, a leading provider of cancer screening and diagnostic tests, today announced that the UK’s National Institute for Health and Care Excellence (NICE) has recommended the expanded use of the Oncotype DX Breast Recurrence Score® test to more effectively target chemotherapy treatment for women who have hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), early-stage breast cancer involving up to three positive nodes and who have been through the menopause.

15 May 2024

New Quartet nanocage vaccine shows promise against coronavirus variants

Researchers have developed a novel vaccination approach using Quartet nanocages that display receptor-binding domains (RBDs) from different sarbecoviruses, showing enhanced immune responses and potential protection against diverse coronavirus strains including SARS-CoV-2 and its variants.

8 May 2024

Durable lymph-node expansion improves vaccine responses against tumors

Each one of us has around 600 lymph nodes (LNs) – small, bean-shaped organs that house various types of blood cells and filter lymph fluid – scattered throughout our bodies.

6 May 2024