Lymphocytic Choriomeningitis News and Research

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Lymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease that presents as aseptic meningitis (inflammation of the membrane, or meninges, that surrounds the brain and spinal cord), encephalitis (inflammation of the brain), or meningoencephalitis (inflammation of both the brain and meninges). Its causative agent is the lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae that was initially isolated in 1933. Although LCMV is most commonly recognized as causing neurological disease, as its name implies, infection without symptoms or mild febrile illnesses are common clinical manifestations. Additionally, pregnancy-related infection has been associated with congenital hydrocephalus, chorioretinitis, and mental retardation.
Researchers show SARS-CoV-2 genes can be integrated into the human genome

Researchers show SARS-CoV-2 genes can be integrated into the human genome

Host cell transmembrane protein MARCH8 targets lysine residues to inhibit SARS-CoV-2 and other viruses

Host cell transmembrane protein MARCH8 targets lysine residues to inhibit SARS-CoV-2 and other viruses

Researchers shed light on T-cell receptor activation in response to infection

Researchers shed light on T-cell receptor activation in response to infection

Using two different viruses to tackle tumors

Using two different viruses to tackle tumors

New tool enables study of SARS-CoV-2 mutant spectrum by ultrasequencing

New tool enables study of SARS-CoV-2 mutant spectrum by ultrasequencing

Study: SphK2 enzyme regulates immune cell responses during viral infection

Study: SphK2 enzyme regulates immune cell responses during viral infection

Researchers identify mechanisms leading to immune 'exhaustion' in severe viral infections

Researchers identify mechanisms leading to immune 'exhaustion' in severe viral infections

Discovery provides a potential target for infectious diseases immunotherapy

Discovery provides a potential target for infectious diseases immunotherapy

Rigidity of tissues drives immune system activity, UCLA study finds

Rigidity of tissues drives immune system activity, UCLA study finds

New method for discovering potential cancer-treating compounds

New method for discovering potential cancer-treating compounds

New screening method can rapidly discover potential cancer-treating compounds

New screening method can rapidly discover potential cancer-treating compounds

Key mechanism identified for how antiviral immune responses reprogram liver metabolism

Key mechanism identified for how antiviral immune responses reprogram liver metabolism

CRISPR RNA-cutting enzyme programmed to destroy viruses in human cells

CRISPR RNA-cutting enzyme programmed to destroy viruses in human cells

New insight may allow researchers to design drugs that improve immune responses to vaccines

New insight may allow researchers to design drugs that improve immune responses to vaccines

Swiss scientists create artificial viruses to combat cancer cells

Swiss scientists create artificial viruses to combat cancer cells

Experimental treatment tempers HLH, MS symptoms in mouse models, study shows

Experimental treatment tempers HLH, MS symptoms in mouse models, study shows

Research findings could lead to development of novel therapeutic approaches against viral infections

Research findings could lead to development of novel therapeutic approaches against viral infections

Suppressed vaginal immune response makes women more susceptible to RNA viruses

Suppressed vaginal immune response makes women more susceptible to RNA viruses

TSRI researchers uncover mechanism behind T cell exhaustion

TSRI researchers uncover mechanism behind T cell exhaustion

Metabolic-checkpoint inhibitor combination approach may improve cancer therapies

Metabolic-checkpoint inhibitor combination approach may improve cancer therapies