Macromolecules News and Research

RSS

Uncovering the Structure of HIV Integrase to Inform Drug Discovery

In this interview Dr Kushol Gupta, Research Assistant Professor in the Department of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania talks to News-Medical and Life Sciences about the importance of light scattering techniques for investigating structure and mechanism of action in his ongoing research into HIV integrase and the development of HIV therapeutics.

From Waters | Wyatt Technology 24 Apr 2019

New custom-designed substrates developed for use in cryo-Electron Microscopy

Cryogenic-Electron Microscopy has been a game changer in the field of medical research, but the substrate, used to freeze and view samples under a microscope, has not advanced much in decades.

24 Apr 2019

Researchers succeed in accelerating process of creating 3D images

Lensless microscopy with X-rays, or coherent diffractive imaging, is a promising approach. It allows researchers to analyze complex three-dimensional structures, which frequently exist in nature, from a dynamic perspective.

17 Apr 2019

Neuronal transport factor detects its target transcripts in more complex manner than previously thought

A team of scientists from Helmholtz Zentrum München and the University of Ulm has discovered that the neuronal transport factor Staufen2 scans and binds to its target transcripts in a much more complex manner than previously thought.

16 Apr 2019

Scientists create a functioning 3D printed heart

Researchers from Tel Aviv University have engineered the world’s first perfectly functioning, immunologically, cellular, biochemically and anatomically matched 3D printed heart.

15 Apr 2019

World's first 3D heart printed using patient's own cells and biological materials

In a major medical breakthrough, Tel Aviv University researchers have "printed" the world's first 3D vascularised engineered heart using a patient's own cells and biological materials.

15 Apr 2019

Postnova Analytics offers customer-friendly high performance MALS detector

The PN3621 Multi-Angle Light Scattering detector from Postnova Analytics combines outstanding performance, high precision and reliability design features to facilitate advanced characterization of proteins, conjugates, macromolecules, and nanoparticles.

From Postnova Analytics 3 Apr 2019

Probing Submicron Protein Aggregation using Asymmetrical Flow Field-Flow Fractionation, AF4, and Light Scattering

The most recent developments by Wyatt in their instrumentation and software have made the full potential of FFF accessible to a wider user base. In this interview, Kim R. Williams and Christoph Johann talk to News-Medical and Life Sciences about the technologies and their research.

From Waters | Wyatt Technology 27 Mar 2019

Novel hydrogel provides better cell encapsulation and delivery

Tissue engineering is a medical solution that uses living cells to repair or replace structural tissue, such as blood vessels, bone, cartilage, etc.

26 Mar 2019

Postnova Analytics AF4 system improves characterization of nanoformulated medicines

Postnova Analytics reports on a recent independent review which details how Asymmetric Flow Field Flow Fractionation is a valuable technique to improve the quality of nanoformulated medicines.

From Postnova Analytics 25 Feb 2019

Drug cocktail may help combat breast cancer

MYC, a gene with high cancer-initiating potential, is overexpressed in over 40% of breast cancers. While MYC programs breast cancer cells to build more macromolecules (anabolic metabolism) it also creates a metabolic vulnerability by making them more sensitive to a type of cell death known as apoptosis.

6 Feb 2019

Nine early career scientists named 2019 recipients of the Damon Runyon-Rachleff Innovation Award

The Damon Runyon Cancer Research Foundation announced that nine scientists with novel approaches to fighting cancer have been named 2019 recipients of the Damon Runyon-Rachleff Innovation Award.

24 Jan 2019

New bacteria-based drug delivery system could radically expand cancer treatment options

An interdisciplinary team of three Virginia Tech faculty members affiliated with the Macromolecules Innovation Institute has created a drug delivery system that could radically expand cancer treatment options.

21 Dec 2018

Study uncovers initial folding mechanism of membrane proteins, key in design of new drugs

An international team coordinated by the Interdisciplinary Research Structure in Biotechnology and Biomedicine of the University of Valencia has proved how the folding of membrane proteins begins before they are inserted into biological membranes, a fact that has been central to the biochemical research for decades.

19 Dec 2018

Inflating cells to analyze organelle structure and function

Researchers have developed a technique that enables visualization of cellular organelles at a resolution that has not previously been achievable in optical microscopy.

17 Dec 2018

New method to block immunosuppression in cancer discovered

Belgian research groups from the UCLouvain and WELBIO, VIB and Ghent University, and the biotechnology company argenx elucidated the three-dimensional structure of an assembly of proteins operating on cells that dampen immune responses

26 Oct 2018

Key insights into the application, production of bioactive materials

Anatomy, Modeling and Biomaterial Fabrication for Dental and Maxillofacial Applications provides readers with information about dental implants and biomaterial fabrication for maxillofacial procedures and dental bone / tissue repair.

19 Oct 2018

Hybrid theranostic complex shows high therapeutic efficacy against tumor cells

Emerging cancer nanotechnology enables target-delivery of substantial payloads of drugs to cancer sites with concomitant reduction of side-effects due to the lesser accumulation in the critical organs.

25 Sep 2018

Thermo Fisher Scientific and Diamond collaborate to launch new cryo-EM capability for use in life sciences industry

An agreement to launch a new cryo-EM capability for use in the life sciences industry sector by Thermo Fisher Scientific, one of the world leaders in high-end scientific instrumentation, and Diamond Light Source, the UK’s national synchrotron and one of the most advanced scientific facilities in the world, was announced today at the official opening of the new national electron bio-imaging center at Diamond.

From Thermo Fisher Scientific – Electron Microscopy Solutions 14 Sep 2018

PARP inhibitors show promise for treating and preventing brain disorders

A class of cancer drugs called PARP inhibitors could be useful for treating and preventing brain disorders, including amyotrophic lateral sclerosis, also called Lou Gehrig's disease, and some forms of frontotemporal degeneration, by halting the misplacement of specific proteins that affect nerve cells, according to a study published in Molecular Cell by researchers in the the School of Arts and Sciences and the Perelman School of Medicine at the University of Pennsylvania.

10 Aug 2018