Major Depressive Disorder News and Research

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Major Depressive Disorder (MDD) is a psychiatric condition characterized by depressed mood or anhedonia (significant loss of interest or pleasure). The condition affects more than 15.7 million adults and approximately 3 million adolescents (aged 13 to 17 years) in the USA each year.

Neurofeedback can change guilt-related brain connectivity in patients with Major Depression Disorder

A study published in the journal Neuroimage: Clinical found that patients with Major Depressive Disorder, who had recovered from symptoms, were able to strengthen some of their brain connections whilst thinking about guilt-evoking memories, thereby increasing their self-esteem.

10 Oct 2019

Long-term study data shows DBS is effective for patients with treatment-resistant depression

A study published online on Friday, October 4, in the American Journal of Psychiatry found that deep brain stimulation (DBS) of an area in the brain called the subcallosal cingulate (SCC) provides a robust antidepressant effect that is sustained over a long period of time in patients with treatment-resistant depression--the most severely depressed patients who have not responded to other treatments.

4 Oct 2019

People with anxiety may resist relaxation and continue worrying to avoid the letdown

Relaxing is supposed to be good for the body and soul, but people with anxiety may actively resist relaxation and continue worrying to avoid a large jump in anxiety if something bad does happen, according to Penn State research.

30 Sep 2019

Handling grief reactions in traumatically bereaved youth after 9/11

Grief reactions in traumatically bereaved youth, particularly in relation to a shared trauma, constitute a unique aspect of psychological distress.

30 Sep 2019

People with severe insomnia may benefit from sedatives, shows study

Insomnia is a driver of suicide, and particularly people with severe insomnia may safely benefit from taking a sedative to help address their sleep problems as it reduces their suicidal thoughts, investigators report.

30 Sep 2019

Researchers use AI to predict depression outcomes

The psychiatry field has long sought answers to explain why antidepressants help only some people.

25 Sep 2019

Individuals with many different psychiatric disorders have heightened impulsivity, study finds

Individuals with many different psychiatric disorders have a higher tendency to choose smaller, immediate rewards over larger, delayed rewards, a study led by Hamilton researchers has found.

28 Aug 2019

Diabetes in college students linked to depression and distress

Diabetes mellitus affects about 10% of the population, and predisposes the affected individual to a host of complications. Thus these patients need to follow a regulated lifestyle, including regular exercise, a low-sugar diet, regular and appropriate use of diabetes medication, self-testing for glucose levels and adjusting medication if used, and scheduled or necessary follow-up with a healthcare provider.

27 Aug 2019

Exercise and increased physical activity are effective for prevention, treatment of depression

Exercise training and increased physical activity are effective for both prevention and treatment of depression, concludes a research review in the August issue of Current Sports Medicine Reports, official journal of the American College of Sports Medicine.

12 Aug 2019

Individual differences in pleasure are due to genetic variation, research suggests

Differences in how our brains respond when we're anticipating a financial reward are due, in part, to genetic differences, according to research with identical and fraternal twins published in Psychological Science, a journal of the Association for Psychological Science.

9 Aug 2019

Obstructive sleep apnea may be one reason for treatment-resistant depression

When someone is depressed and having suicidal thoughts or their depression treatment just isn't working, their caregivers might want to check to see if they have obstructive sleep apnea, investigators say.

23 Jul 2019

New structured approach to managing patients with depression in primary care

A questionnaire-based management algorithm for major depressive disorder in primary care is feasible to implement, though attrition from treatment is high.

11 Jul 2019

Study: Antidepressants reduce mortality by 35% in patients with diabetes

Antidepressants reduce deaths by more than a third in patients with diabetes and depression, according to a study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

2 Jul 2019

Weighing risks and benefits of antidepressant medication for older adults

Depression is a common and serious problem for older adults. Some 15 to 20 percent of people aged 65 and older who live independently deal with symptoms of major depressive disorder.

12 Jun 2019

Study: Underweight boys and overweight girls have increased risk of depression

The results of a large community-based study have shown that the probability of major depressive disorder in children and adolescents with high, low, or normal body mass index differs according to gender.

12 Jun 2019

Anti-inflammatory medicine can be effective in treating people with depression

The World Health Organization calls depression one of the most serious mental disorders, and researchers around the world are trying to improve treatment of the disease.

8 Apr 2019

People with treatment-resistant depression at higher risk of developing substance use syndrome

People suffering from treatment resistant depression are at a higher risk of developing substance use disorders than other patients with depression, reports a study by researchers at Karolinska Institutet in Sweden published in the journal Addiction.

2 Apr 2019

Depression symptoms associated with death among patients with HIV infection

In a new study to investigate the relationship among depressive disorders or symptoms, HIV status and mortality, researchers report that symptoms of depression are moderately associated with death among Veterans with HIV but not among those without HIV infection.

2 Apr 2019

Antidepressant drugs may not work when neurons are out of shape

elective serotonin reuptake inhibitors are the most commonly prescribed medication for major depressive disorder, yet scientists still do not understand why the treatment does not work in nearly thirty percent of patients with MDD.

22 Mar 2019

Early life trauma may affect brain structure, contribute to major depressive disorder

Early life trauma may affect the structure of the brain in a way that makes clinical depression more likely to be severe and recurrent, according to a two-year observational study of 110 patients published in The Lancet Psychiatry journal.

22 Mar 2019

Major Depressive Disorder News and Research

Further Reading

Neurofeedback can change guilt-related brain connectivity in patients with Major Depression Disorder

Long-term study data shows DBS is effective for patients with treatment-resistant depression

People with anxiety may resist relaxation and continue worrying to avoid the letdown

Handling grief reactions in traumatically bereaved youth after 9/11

People with severe insomnia may benefit from sedatives, shows study

Researchers use AI to predict depression outcomes

Individuals with many different psychiatric disorders have heightened impulsivity, study finds

Diabetes in college students linked to depression and distress

Exercise and increased physical activity are effective for prevention, treatment of depression

Individual differences in pleasure are due to genetic variation, research suggests

Obstructive sleep apnea may be one reason for treatment-resistant depression

New structured approach to managing patients with depression in primary care

Study: Antidepressants reduce mortality by 35% in patients with diabetes

Weighing risks and benefits of antidepressant medication for older adults

Study: Underweight boys and overweight girls have increased risk of depression

Anti-inflammatory medicine can be effective in treating people with depression

People with treatment-resistant depression at higher risk of developing substance use syndrome

Depression symptoms associated with death among patients with HIV infection

Antidepressant drugs may not work when neurons are out of shape

Early life trauma may affect brain structure, contribute to major depressive disorder

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