Metabolic Disorders News and Research

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Infant formulas containing fructose pose risk to babies with hereditary fructose intolerance

Babies with inherited intolerance of fructose face a risk of acute liver failure if they are fed certain widely available formulas containing fructose, pediatricians and geneticists are warning.

18 May 2018

Study provides insights into how immune cells kill bacteria with acid

The first line of immune defense against invading pathogens like bacteria are macrophages, immune cells that engulf every foreign object that crosses their way. After enclosing it in intracellular membrane vesicles, a process called phagocytosis, macrophages kill their prey with acid.

17 May 2018

Findings confirm analytical principle that describes mutational processes and cancer development

When a cell develops into a tumor, something has gone terribly wrong: the uncontrolled growth, invasion of nearby tissues and finally metastasis are the result of many consecutive DNA mutations.

9 May 2018

Nuclear pore complexes are critical for survival of circulating T cells, study shows

Nuclear pore complexes in the nuclear membrane not only control the transport of molecules into and out of the nucleus- they play an essential role in the survival of T cells.

8 May 2018

Study provides vital information to develop successful PI5P4K inhibitors for p53-mutant cancers

One major hallmark of cancer cells is their ability to adapt to stressful conditions such as nutrient deprivation. Rapidly growing tumor cells must compete for the ever-diminishing supply of nutrients in the surrounding environment to survive and proliferate. Targeting these adaptive mechanisms represents a promising approach for cancer therapeutics.

3 May 2018

Study explains how colon cancer cells spread to the liver

Colorectal cancer is the third most common cancer worldwide and the third-leading cause of cancer-related deaths. The main cause of death in patients with colorectal cancer is liver metastasis, with nearly 70% of patients eventually developing a liver tumor.

25 Apr 2018

Regular soaking in hot tub improves health outlook in obese women with PCOS

According to new research, obese women with polycystic ovary syndrome may be able to improve their health outlook with a particularly enjoyable form of therapy: regular sessions in a hot tub.

25 Apr 2018

Study proposes new mechanism that may contribute to gender differences in weight control

For years, scientists have observed that when male and female mice eat the same high-fat diet, the males gain significantly more weight than the females.

18 Apr 2018

Breastfeeding mothers who overeat may increase risk of health problems in offspring

Mothers who overeat during the period when they are breastfeeding may have children who are at increased risk of becoming obese and going through early puberty, a new study of mice suggests.

19 Mar 2018

Boosting the brain's immune cells may prevent or reduce severity of Alzheimer's disease

Sanford Burnham Prebys Medical Research Institute researchers have published two new studies in Neuron that describe how TREM2, a receptor found on immune cells in the brain, interacts with toxic amyloid beta proteins to restore neurological function.

8 Mar 2018

New study provides better understanding of asymmetric cell division

Stem cells are the basic material from which mature, specialised cells such as muscle and blood cells are produced -- this process is known as differentiation.

28 Feb 2018

Altered immune cell clocks may contribute to metabolic diseases in shift workers

About 15 million Americans don't have a typical nine-to-five workday, and many of these--nurses, firefighters and flight attendants, among many other professions--may see their schedule change drastically one week to the next.

7 Feb 2018

Discovery may advance stem cell therapies, gene-targeting treatments for neurological diseases

New research from Sanford Burnham Prebys Medical Discovery Institute is among the first to describe how an mRNA modification impacts the life of neural stem cells.

24 Jan 2018

Women with PCOS likely to have less diverse gut bacteria, study reveals

Women who have a common hormone condition that contributes to infertility and metabolic problems tend to have less diverse gut bacteria than women who do not have the condition, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

23 Jan 2018

Metabolic shift can result in congestive heart failure

The heart derives its energy primarily from fatty acids. However, if a metabolic shift to other energy sources takes place, this can result in congestive heart failure, scientists from the German Cancer Research Center and Heidelberg University Hospital have now discovered.

23 Jan 2018

EXD2 enzyme facilitates protein production in mitochondria

Researchers from the Genomic Instability and Cancer Laboratory at Institute for Research in Biomedicine (IRB Barcelona) have identified a key role for EXD2 in protein production in the mitochondria, the cellular organelles responsible for the majority of energy generation.

17 Jan 2018

Metabolic Disorders News and Research

Infant formulas containing fructose pose risk to babies with hereditary fructose intolerance

Study provides insights into how immune cells kill bacteria with acid

Findings confirm analytical principle that describes mutational processes and cancer development

Nuclear pore complexes are critical for survival of circulating T cells, study shows

Study provides vital information to develop successful PI5P4K inhibitors for p53-mutant cancers

Study explains how colon cancer cells spread to the liver

Regular soaking in hot tub improves health outlook in obese women with PCOS

Study proposes new mechanism that may contribute to gender differences in weight control

Breastfeeding mothers who overeat may increase risk of health problems in offspring

Boosting the brain's immune cells may prevent or reduce severity of Alzheimer's disease

New study provides better understanding of asymmetric cell division

Altered immune cell clocks may contribute to metabolic diseases in shift workers

Discovery may advance stem cell therapies, gene-targeting treatments for neurological diseases

Women with PCOS likely to have less diverse gut bacteria, study reveals

Metabolic shift can result in congestive heart failure

EXD2 enzyme facilitates protein production in mitochondria

3D images of fat cells reveal potential targets to fight against obesity

Newly solved glucagon receptor structure provides most accurate template for drug design

Research reveals how fiber in the diet contributes to colonic health

Study reveals biology behind why muscle stem cells respond differently to aging or injury

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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