Metabolites News and Research

RSS

New process could reinvigorate the search for natural product drugs to treat cancers, viral infections

Researchers from Carnegie Mellon University's Computational Biology Department in the School of Computer Science have developed a new process that could reinvigorate the search for natural product drugs to treat cancers, viral infections and other ailments.

3 Jun 2021

A newly developed electronic ‘nose’ could identify COVID-19-infection

Developing rapid diagnostic tools is key to dealing with the COVID-19 pandemic, and a new electronic-based ‘nose’ detector could identify cases in 80 seconds.

2 Jun 2021

Researchers find natural metabolites help SARS-CoV-2 escape antibodies

An international team of scientists has identified a human molecule — biliverdin — as a potential severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) target. The binding of the heme metabolite to the N-terminal domain of SARS-CoV-2 is associated with the virus’s ability to dodge the immune system by suppressing antibody binding to the spike protein.

2 Jun 2021

“Good” bacteria demonstrate clinical potential for treating ulcerative colitis, Crohn's disease

A new study published in Nature Communications demonstrates that a consortium of bacteria designed to complement missing or underrepresented functions in the imbalanced microbiome of inflammatory bowel disease (IBD) patients, prevented and treated chronic immune-mediated colitis in humanized mouse models.

29 May 2021

Researchers use genomic sequencing technique to detect presence of various microbes

About 12,000 bacteria and viruses collected in a sampling from public transit systems and hospitals around the world from 2015 to 2017 had never before been identified, according to a study by the International MetaSUB Consortium, a global effort at tracking microbes that is led by Weill Cornell Medicine investigators.

27 May 2021

Blood sample analysis can help determine the origin of drugs

The opioid fentanyl is not only used in medical practice as a painkiller, but is also a popular recreational drug. In the United States in particular, fentanyl plays an important role in the opioid crisis that claims many victims every day.

27 May 2021

Study sheds new light on complex dynamics involved in microbial infections

Included in the vast fallout stemming from the COVID-19 pandemic, scientists are paying closer attention to microbial infections and how life forms defend against attacks from pathogens.

27 May 2021

Antithrombotic endothelial dysfunction is prevented by Tie2 activation in severe COVID-19

Researchers from the US recently assessed if severe COVID-19 is linked to procoagulant dysfunction of the endothelium and changes in the Tie2-angiopoietin axis. They assessed circulating endothelial markers in a study cohort of 98 patients with mild, moderate, or severe COVID-19. This study is published on the medRxiv* preprint server.

19 May 2021

Measuring metabolic 'fluxes' could help scientists advance new tuberculosis drugs

Mycobacterium tuberculosis is incredible in that it can survive for decades within its human host. It does this by varying its diet to successfully steal nutrients from the human host including immune cells; it is known to acquire and absorb multiple carbon sources from the body during infection.

12 May 2021

Natural products a rich source for novel antiviral compounds

In a recent review in the journal Viruses, researchers look at natural products that can be identified as potential alternative antiviral agents. The reviewers discussed the antiviral activities of several natural products towards DNA and RNA viruses with an analytical approach. The researchers detailed the cellular/viral targets of the active molecules and their impact on the infection and viral replication cycle.

10 May 2021

SARS-CoV-2 infection prolongs viral shedding and lymphocyte loss in patients with cancer

Patients with cancer have a more challenging time with infections while undergoing treatment — placing them as high-risk for severe COVID-19 illness and death. However, how the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interacts with cancer therapies remains poorly understood.

7 May 2021

Could in vitro glycoengineering help produce better SARS-CoV-2 spike candidates for vaccine research?

A vexing problem in the development of vaccines has been the need to achieve the right glycosylation profile for the viral antigens. A new study, recently released as a preprint on the bioRxiv* server, shows how a sequential cell-free approach produced complex N-glycans from simpler types, in a one-pot reaction.

4 May 2021

New study launched to more accurately diagnose early hepatocellular carcinoma

A first of its kind cohort study on patients at high risk of developing primary liver cancer also known as hepatocellular carcinoma (HCC), has been launched to diagnose HCC more accurately at an earlier stage and to predict an individual's likelihood of developing the cancer.

3 May 2021

Researchers create new, open-access tool for assessing infant brain health

Researchers have created a new, open-access tool that allows doctors and scientists to evaluate infant brain health by assessing the concentration of various chemical markers, called metabolites, in the brain. The tool compiled data from 140 infants to determine normal ranges for these metabolites.

29 Apr 2021

Processed diets may promote diseases characterized by low-grade infection and inflammation

Processed diets, which are low in fiber, may initially reduce the incidence of foodborne infectious diseases such as E. coli infections, but might also increase the incidence of diseases characterized by low-grade chronic infection and inflammation such as diabetes, according to researchers in the Institute for Biomedical Sciences at Georgia State University.

28 Apr 2021

SARS-CoV-2 recruits heme metabolites in antibody evasion

A research paper recently published in the journal Science Advances by Cherepanov et al. (April 22nd, 2021) demonstrated that the NTD binds to biliverdin, a product of heme catabolism, leading to enhanced antibody escape at physiologically relevant concentrations.

28 Apr 2021

High dose of vitamin D does not have a beneficial effect on moderate or severe COVID-19 patients

Can a high dose of vitamin D administered on admission to hospital improve the condition of patients with moderate or severe COVID-19? The answer is no, according to a Brazilian study published in the Journal of the American Medical Association.

23 Apr 2021

Researchers identify natural molecule that blocks the binding of human antibodies to SARS-CoV-2

Researchers have found that a natural molecule can effectively block the binding of a subset of human antibodies to SARS-CoV-2. The discovery may help explain why some COVID-19 patients can become severely ill despite having high levels of antibodies against the virus.

23 Apr 2021

Experts to present latest research on aging and longevity at the 8th Aging Research & Drug Discovery Meeting

Scheibye-Knudsen Lab, University of Copenhagen and Deep Longevity are excited to reveal the speakers for the 8th Aging Research & Drug Discovery Meeting, the largest scientific academic, and industry conference that will transpire on August 31 - September 3, 2021, on-site at the Ceremonial Hall, University of Copenhagen, and online.

22 Apr 2021

Metabolic testing of COVID-19 patients through skin imprints

There is, therefore, a great need to understand how the illness can be diagnosed using more convenient and inexpensive methods. A new study posted to the medRxiv preprint server reveals the potential role of skin imprints to test for biomarkers that indicate a diagnosis of COVID-19 in a non-invasive way.

22 Apr 2021

Metabolites News and Research

New process could reinvigorate the search for natural product drugs to treat cancers, viral infections

A newly developed electronic ‘nose’ could identify COVID-19-infection

Researchers find natural metabolites help SARS-CoV-2 escape antibodies

“Good” bacteria demonstrate clinical potential for treating ulcerative colitis, Crohn's disease

Researchers use genomic sequencing technique to detect presence of various microbes

Blood sample analysis can help determine the origin of drugs

Study sheds new light on complex dynamics involved in microbial infections

Antithrombotic endothelial dysfunction is prevented by Tie2 activation in severe COVID-19

Measuring metabolic 'fluxes' could help scientists advance new tuberculosis drugs

Natural products a rich source for novel antiviral compounds

SARS-CoV-2 infection prolongs viral shedding and lymphocyte loss in patients with cancer

Could in vitro glycoengineering help produce better SARS-CoV-2 spike candidates for vaccine research?

New study launched to more accurately diagnose early hepatocellular carcinoma

Researchers create new, open-access tool for assessing infant brain health

Processed diets may promote diseases characterized by low-grade infection and inflammation

SARS-CoV-2 recruits heme metabolites in antibody evasion

High dose of vitamin D does not have a beneficial effect on moderate or severe COVID-19 patients

Researchers identify natural molecule that blocks the binding of human antibodies to SARS-CoV-2

Experts to present latest research on aging and longevity at the 8th Aging Research & Drug Discovery Meeting

Metabolic testing of COVID-19 patients through skin imprints

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

Latest News