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Drinkable, carbon monoxide-infused foam supercharges cancer therapy

Did smokers do better than non-smokers in a clinical trial for an experimental cancer treatment? That was the intriguing question that led University of Iowa researchers and their colleagues to develop a drinkable, carbon monoxide-infused foam that boosted the effectiveness of the therapy, known as autophagy inhibition, in mice and human cells.

12 Jan 2024

Unlocking protein secrets: X-ray crystallography reveals hidden shapes

Proteins do the heavy lifting of performing biochemical functions in our bodies by binding to metabolites or other proteins to complete tasks.

12 Jan 2024

New molecule targets key protein in autoimmune diseases

Scientists from Scripps Research have developed a small molecule that blocks the activity of a protein linked to autoimmune diseases, including systemic lupus erythematosus (SLE) and Crohn's disease.

11 Jan 2024

Study sheds light on how impaired autophagy can play a role in causing heart failure

A new study sheds light on how autophagy, the body's process for removing damaged cell parts, when impaired, can play a role in causing heart failure.

11 Jan 2024

Extended liver preservation technique shows promise for daytime transplants

Phase II clinical trial evaluates the safety and feasibility of prolonged DHOPE for extending human donor liver preservation to 20 hours, showing potential for facilitating daytime liver transplantation.

11 Jan 2024

Study uncovers new weapon against PARP inhibitor-resistant ovarian cancers

A new editorial paper was published in Oncotarget's Volume 14 on December 22, 2023, entitled, "One more step toward treatment of PARP inhibitor-resistant ovarian cancers."

10 Jan 2024

mRNA therapy shows promise for curing children's rare liver disease

By exploiting the technology used in Covid-19 vaccines, a team led by UCL, King's College London and Moderna scientists has created an effective therapy for a rare disease, in a study in mice, demonstrating the technology's potential therapeutic use in people.

10 Jan 2024

Protein secrets revealed: Single-molecule spectroscopy ushers in era of personalized medicine

Infrared vibrational spectrum of a single protein is observed using advanced measurement techniques based on near-field optical microscopy.

9 Jan 2024

Breakthrough in gene editing: Enhanced virus-like particles promise new era in genetic disease treatment

Researchers developed an advanced prime editor-engineered virus-like particle (PE-eVLP) system, significantly enhancing gene editing efficiency in human cells and showing potential for treating genetic diseases.

9 Jan 2024

Scripps scientists debunk long-held theory about alcohol and the brain

Ethanol-;the compound found in alcoholic beverages-;interferes with the normal functioning of a long list of biological molecules, but how each of these interactions contributes to the behavioral effects of alcohol is not fully understood.

8 Jan 2024

New test detects Parkinson's disease before symptoms appear

In the development of Parkinson's disease (PD), the changes that will lead to neurodegeneration take place in the brain long before patients show any symptoms.

8 Jan 2024

Bacterial "freight elevator" unpacked: How pathogens hide from the immune system

Some bacterial membrane transporters work almost like freight elevators to transport substances through the cell membrane into the interior of the cell. The transporter itself spans the bacterial membrane.

8 Jan 2024

Revolutionary study reveals Lactobacillus acidophilus could ward off liver cancer linked to fatty liver disease

Probiotic supplementation with Lactobacillus acidophilus could help prevent non-alcoholic fatty liver disease.

8 Jan 2024

St. Jude scientists develop novel spectinomycin derivatives to combat Mycobacterium abscessus

Scientists at St. Jude Children's Research Hospital are tackling Mycobacterium abscessus (Mab) antibiotic resistance.

5 Jan 2024

Stapled lipopeptides show promise as broad-spectrum antiviral agents

Compounds that obstruct the "landing gear" of a range of harmful viruses can successfully protect against infection by the virus that causes COVID-19, a study published today and led by Dana-Farber Cancer Institute scientists shows.

5 Jan 2024

Epilepsy drug may alleviate joint degeneration associated with osteoarthritis

A new study in Nature described Nav1.7 as a key regulatory molecule in cartilage cells and reported the effectiveness of Nav1.7 blockade in reducing pain and slowing progression in OA.

5 Jan 2024

Unlocking the power of diet: How miRNAs influence health and disease

The role of dietary microRNAs (miRNAs) in health and disease.

5 Jan 2024

Metabolically armored CAR-T cells demonstrate lasting efficacy against solid tumors

At EPFL's School of Engineering, Professor Li Tang's Laboratory of Biomaterials for Immunoengineering has made significant strides in cancer treatment research.

4 Jan 2024

Revolutionary RNA-based switch offers new control over gene expression in mammalian cells

Researchers developed an RNA-based switch, the pA regulator system, to control gene expression in mammalian cells by modulating synthetic polyA signal cleavage, offering a novel approach for gene therapy applications.

4 Jan 2024

Researchers develop peptide to target "chaotic" MYC protein in 75% of cancers

Meet MYC, the shapeless protein responsible for making the majority of human cancer cases worse.

4 Jan 2024

Molecule News and Research

Drinkable, carbon monoxide-infused foam supercharges cancer therapy

Unlocking protein secrets: X-ray crystallography reveals hidden shapes

New molecule targets key protein in autoimmune diseases

Study sheds light on how impaired autophagy can play a role in causing heart failure

Extended liver preservation technique shows promise for daytime transplants

Study uncovers new weapon against PARP inhibitor-resistant ovarian cancers

mRNA therapy shows promise for curing children's rare liver disease

Protein secrets revealed: Single-molecule spectroscopy ushers in era of personalized medicine

Breakthrough in gene editing: Enhanced virus-like particles promise new era in genetic disease treatment

Scripps scientists debunk long-held theory about alcohol and the brain

New test detects Parkinson's disease before symptoms appear

Bacterial "freight elevator" unpacked: How pathogens hide from the immune system

Revolutionary study reveals Lactobacillus acidophilus could ward off liver cancer linked to fatty liver disease

St. Jude scientists develop novel spectinomycin derivatives to combat Mycobacterium abscessus

Stapled lipopeptides show promise as broad-spectrum antiviral agents

Epilepsy drug may alleviate joint degeneration associated with osteoarthritis

Unlocking the power of diet: How miRNAs influence health and disease

Metabolically armored CAR-T cells demonstrate lasting efficacy against solid tumors

Revolutionary RNA-based switch offers new control over gene expression in mammalian cells

Researchers develop peptide to target "chaotic" MYC protein in 75% of cancers

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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