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Potential new cancer fighting drug found by mistake

Researchers in the United States appear to have almost inadvertently stumbled across what could be a new cancer treatment.

5 Feb 2007

Corn, oats, cherries and red wine's high melatonin content can help delay ageing

The Spanish Ageing Research Network (Red Nacional de Investigación del Envejecimiento), funded by Carlos III Health Institute and headed by professor Darío Acuna Castroviejo, from the University of Granada, is very near to achieving one of today's Science greatest goals: allowing humans to age in the best possible health conditions.

31 Jan 2007

Probing proteins can lead to better understanding of anti-tumor agents

There are a number of naturally occurring chemicals that are used in phototherapy of skin diseases. Hypocrellin A (HA), which can be extracted from a parasitic fungus, has been taken orally as a folk medicine for several centuries in China.

29 Jan 2007

Scientists tackle huntingtin protein

McMaster scientists are very close to defining small molecule drugs that should be able to redirect the huntingtin protein from accumulating in the wrong place within brain cells, which could potentially translate to a therapy for Huntington's Disease (HD).

29 Jan 2007

Design of gold nanoparticles for magnetic resonance imaging

Molecular complexes containing the element gadolinium are proven agents for increasing the diagnostic utility of magnetic resonance imaging (MRI), but their use in detecting small tumors is limited by the relatively weak signal these agents produce.

29 Jan 2007

SH2B1 protein plays a key role in controlling body weight, response to insulin and leptin

A single protein in brain cells may act as a linchpin in the body's weight-regulating system, playing a key role in the flurry of signals that govern fat storage, sugar use, energy balance and weight, University of Michigan Medical School researchers report.

29 Jan 2007

Cellular mechanism linked to inflammation and cancer

A team led by biochemists at the University of California, San Diego has found what could be a long-elusive mechanism through which inflammation can promote cancer. The findings may provide a new approach for developing cancer therapies.

28 Jan 2007

RNA used to turn on genes to alleviate disease

A new technique that employs RNA, a tiny chemical cousin of DNA, to turn on genes could lead to therapeutics for conditions in which nudging a gene awake would help alleviate disease, researchers at UT Southwestern Medical Center say.

28 Jan 2007

Small molecule targets weak mRNA

A new strategy for fighting cancer aims to make its genes get lost in translation, according to a report in the January 26, 2007, issue of the journal Cell.

28 Jan 2007

Disorderly protein brings order to cell division

The secret to the ability of a molecule critical for cell division to throw off the protein yoke that restrains its activity is the yoke itself a disorderly molecule that seems to have a mind of its own, say investigators at St. Jude Children's Research Hospital, Innsbruck Medical University and Max Planck Institute.

28 Jan 2007

Possible reason for severe side-effects of Northwick Park clinical trial

A possible reason why the Northwick Park clinical trial of the drug TGN1412 caused multiple organ failure in human volunteers is revealed in research presented at a conference near Paris.

25 Jan 2007

Nano Chemical Systems files patent for breakthrough new material

Nano Chemical Systems announced today that it has filed a US Patent application on a breakthrough new material that exhibits light (luminescent) in the absence of heat.

23 Jan 2007

Single protein plays a major role in prion diseases

A single protein plays a major role in deadly prion diseases by smashing up clusters of these infectious proteins, creating the "seeds" that allow fatal brain illnesses to quickly spread, new Brown University research shows.

23 Jan 2007

Sequella receives FDA fast track status for pulmonary tuberculosis drug

Sequella, Inc. has announced it has received Fast Track designation from the U.S. Food and Drug Administration (FDA) for SQ109, the company's proprietary lead drug candidate for treatment of pulmonary tuberculosis (TB).

22 Jan 2007

Nanoparticles yield delivery tools for therapeutic nucleic acids

Cancer researchers hold great hope that nucleic acid-based therapeutics, such as anticancer genes, antisense oligonucleotides, and small interfering RNA (siRNA) molecules, will prove to be powerful antitumor agents.

16 Jan 2007

Biomimetic amplification of nanoparticle homing to tumors

A collaborative, multidisciplinary team of researchers has created nanoparticles that act much like a developing clot to target tumors.

16 Jan 2007

Fibrinogen molecule structure acts as a molecular spring

Researchers at the University of Pennsylvania School of Medicine and the School of Arts and Sciences have shown that a well-known protein structure acts as a molecular spring, explaining one way that clots may stretch and bend under such physical stresses as blood flow.

14 Jan 2007