Muscle Wasting News and Research

RSS

New book explains about the molecular mechanisms implicated in skeletal muscle aging

Sarcopenia, the progressive loss of muscle mass and associated muscle weakness during aging, affects the functional capacity and general health in adult people radically and renders frail elders susceptible to serious injury from sudden falls and fractures.

21 Jul 2019

Indigestion remedy improves survival in people with late-stage CKD

Defined as serum bicarbonate less than 22 mmol/L, metabolic acidosis is common in people with CKD stages 4-5 (eGFR < 30 ml/min/1.73 m2) and is directly related to worsening kidney function.

17 Jun 2019

Study uncovers trigger for cachexia

Among all major cancers, pancreatic cancer has the highest rate of death - 93 percent of patients die within five years of diagnosis.

13 Jun 2019

Scientists uncover unique set of genes that play a role in muscle cellular gene regulation

York University scientists have uncovered a unique set of genes that play a role in muscle cellular gene expression and differentiation which could lead to new therapeutic targets to prevent the spread of muscle cancer.

23 May 2019

Regular endurance exercise leads to high Nrf2 nuclear translocation, DNA binding activity

Skeletal muscle mass and function becomes progressively compromised with aging, chronic disease, and physical inactivity.

26 Apr 2019

Potential drug targets cause of adult-onset muscular dystrophy

People diagnosed with myotonic dystrophy type 1 have difficulty unclenching muscles due to a genetic defect that generates toxic material within their cells.

1 Apr 2019

Increased muscle mass could save your life

As far back as Ancient Greece, a sculptured physique has been heralded as the pinnacle of physical perfection. But now, researchers from Japan have found that increased muscle mass doesn't just make you look good, it could literally save your life.

4 Mar 2019

UCL and AIIMS collaborates to increase academic and student exchange

UCL and the All India Institute of Medical Sciences have entered into a new partnership which will enable much closer research collaboration and will explore opportunities to increase academic and student exchange between the institutions.

22 Feb 2019

Intense exercise, fasting and hormones can enhance waste-protein removal, study shows

The body's ability to adapt to changing conditions and shifting physiologic demands is essential to survival. To do so, each cell must be able to dispose of damaged or unnecessary proteins--a quality-control mechanism critical for cellular performance and for the health of the entire organism.

21 Feb 2019

Loss of muscle and body weight linked with disability in stroke patients

Loss of muscle and body weight is associated with disability after stroke, reports a study presented today at Heart & Stroke 2019, a meeting of the European Society of Cardiology Council on Stroke, and published in the Journal of Cachexia, Sarcopenia and Muscle.

25 Jan 2019

Failure of critical cellular energy sensor responsible for CKD progression, study finds

Chronic kidney disease, an affliction characterized by progressive loss of kidney function, affects millions of people worldwide and is associated with multi-organ damage, cardiovascular disease, and muscle wasting.

7 Dec 2018

Curry spice may improve exercise intolerance related to heart failure

New research suggests that curcumin, a main ingredient in curry, may improve exercise intolerance related to heart failure. The study is published ahead of print in the Journal of Applied Physiology.

29 Nov 2018

Intensive care patients’ muscles less able to use fats for energy

The muscles of people in intensive care are less able to use fats for energy, contributing to an extensive loss of muscle mass, finds a new study co-led by King's College London, Guy's and St Thomas' NHS Foundation Trust and University College London.

16 Oct 2018

Study: Chemotherapy drugs may promote muscle mitochondrial dysfunction

Chemotherapy drugs to treat breast cancer may promote muscle mitochondrial dysfunction, according to new research. Dysfunctional mitochondria, the energy centers of the cells, may contribute to fatigue and weakness that some people with breast cancer experience through the course of disease treatment.

5 Oct 2018

Muscle dystrophy treatment in dogs with Crispr gene editing

Researchers in the United States have shown that genetically caused muscular dystrophy in dogs could be corrected using genetic editing tools. Muscular dystrophy is one of the most common fatal genetic conditions seen in children and is also seen in dogs

31 Aug 2018

SMA treatment may be effective even if started in children seven months and older

A drug shown to be effective in the treatment of babies with the rare muscle-wasting disease spinal muscular atrophy may be effective for muscle control even when treatment is started in children seven months and older, according to a study published in the August 29, 2018, online issue of Neurology, the medical journal of the American Academy of Neurology. Previous studies focused on children younger than seven months old.

30 Aug 2018

Scientists uncover molecular 'switch' that may control the benefits of exercise

Some people respond well to both aerobic exercise and strength training, while others don't. And some of us respond well to only one of those things, but not both. Scientists at Joslin Diabetes Center now have uncovered a surprising molecular "switch" that may help to explain why this happens.

2 Aug 2018

Muscles of people in intensive care less able to use fats for energy, shows study

The muscles of people in intensive care are less able to use fats for energy, contributing to extensive loss of muscle mass, finds a new study co-led by UCL, King's College London and Guy's and St Thomas' NHS Foundation Trust.

13 Jul 2018

Overload of zinc in muscles leads to cachexia in cancer patients

It's estimated that nearly one-third of all cancer deaths are caused not by the cancer itself but by cachexia-;a debilitating muscle-wasting syndrome that affects an estimated 80 percent of advanced cancer patients. Cachexia is linked to reduced tolerance for cancer therapy, poor quality of life, and accelerated death, but there are no effective treatments and its cause is still largely unknown.

6 Jun 2018

New cell-based technologies could help improve understanding of muscle-wasting disease

Researchers from Queen Mary University of London have developed new cell-based technologies which could help improve understanding of the muscle-wasting disease Duchenne muscular dystrophy (DMD) and test potential drugs for the disease.