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Vertex commences VX-770 and VX-809 combination Phase 2a clinical trial for cystic fibrosis

Vertex Pharmaceuticals Incorporated today announced the initiation of a Phase 2a clinical trial that will evaluate multiple combinations of VX-770 and VX-809, investigational oral cystic fibrosis transmembrane conductance regulator (CFTR) modulators for the treatment of cystic fibrosis (CF). The trial is designed to evaluate the safety and tolerability of VX-809 dosed alone for 14 days followed by dosing of VX-809 in combination with VX-770 for 7 days.

18 Oct 2010

Metabolon announces publication of metabolic analysis of biochemical changes in CF primary lung epithelial cells

Metabolon, Inc., the leader in global metabolomics, biomarker discovery and analysis, announces the publication of "Metabolomic Profiling Reveals Biochemical Pathways and Biomarkers Associated with Pathogenesis in Cystic Fibrosis Cells", in the Journal of Biological Chemistry.

18 Oct 2010

Cempra to present data on solithromycin, TAKSTA at 48th Annual Meeting in Vancouver

Cempra Pharmaceuticals today announced poster presentations on its novel fluoroketolide antibiotic, solithromycin (CEM-101), and the Company's proprietary front-loading oral dosing regimen of sodium fusidate, TAKSTA (CEM-102) at the 48th Annual Meeting of the Infectious Diseases Society of America in Vancouver, British Columbia.

18 Oct 2010

PTC announces ataluren Phase 2b efficacy data at International Congress

PTC Therapeutics, Inc. today announced that final analyses of Phase 2b efficacy data suggest the investigational new drug ataluren slowed the loss of walking ability in patients with nonsense mutation dystrophinopathy, a disease continuum comprising Duchenne and Becker muscular dystrophy (nmDBMD). These data were presented at the International Congress of the World Muscle Society in Kumamoto, Japan and will be the basis of interactions with the U.S. Food and Drug Administration (FDA) and national regulatory authorities in Europe in the fourth quarter of 2010.

18 Oct 2010

Novel approach to automated detection of bacterial pathogens in food

Researchers from the School of Science at Indiana University-Purdue University Indianapolis (IUPUI) and the Bindley Bioscience Center at Purdue University have developed a novel approach to automated detection and classification of harmful bacteria in food. The investigators have designed and implemented a sophisticated statistical approach that allows computers to improve their ability to detect the presence of bacterial contamination in tested samples.

15 Oct 2010

Discovery Labs to present lucinactant Phase 2a clinical study results at NACFC Conference

Discovery Laboratories, Inc. today announces that the Phase 2a clinical study of aerosolized KL4 surfactant (lucinactant) in patients with cystic fibrosis (CF) has completed and the results from the study will be presented at the upcoming North American Cystic Fibrosis Conference (NACFC; October 21-23, 2010).

15 Oct 2010

New development of genetic tool to speed discovery of novel genes involved in cancer

Researchers have developed a genetic tool in mice to speed the discovery of novel genes involved in cancer. The system - called PiggyBac - has already been used by the team to identify novel candidate cancer-causing genes.

15 Oct 2010

Journal of Clinical Oncology publishes IPI-504 Phase 2 study results

Infinity Pharmaceuticals, Inc. announced that results from its Phase 2 study of IPI-504, a novel IV-administered Hsp90 chaperone inhibitor, in patients with advanced non-small cell lung cancer (NSCLC) were published in the Journal of Clinical Oncology.

15 Oct 2010

ARTS protein increases apoptosis mechanism to balance stem cells' regenerative power: Research

Stem cells, the prodigious precursors of all the tissues in our body, can make almost anything, given the right circumstances. Including, unfortunately, cancer. Now research from Rockefeller University shows that having too many stem cells, or stem cells that live for too long, can increase the odds of developing cancer.

15 Oct 2010

Study finds multiple genetic variations can contribute to common childhood obesity

A new study uncovers multiple genetic variations associated with common childhood obesity. The research, published by Cell Press on October 14th in the American Journal of Human Genetics, is likely to guide future studies aimed at characterizing the affected genes and unraveling the complex biology that underlies childhood obesity.

15 Oct 2010

Scientists identify root cause of chromosomal errors and gene diversity

A team led by a scientist at the University of Pittsburgh School of Medicine has discovered a regulatory protein that influences where genetic material gets swapped between maternal and paternal chromosomes during the process of creating eggs and sperm. The findings, which shed light on the roots of chromosomal errors and gene diversity, appear in tomorrow's issue of Nature.

14 Oct 2010

Research may pave way to cure cystic fibrosis

A University of Missouri researcher believes his latest work moves scientists closer to a cure for cystic fibrosis, one of the world's most common fatal genetic diseases.

13 Oct 2010

Cancer Research UK launches programme to turn genetic revolution into better treatment for cancer patients

Cancer Research UK has launched a multimillion pound programme, alongside the Technology Strategy Board's Innovation Platform, to help turn the genetic revolution into better treatment for cancer patients.

13 Oct 2010

Defect in 21st amino acid leads to progressive brain atrophy: Study

A research team at Ben-Gurion University of the Negev and Soroka University Medical Center in Beer-Sheva, Israel has detected a genetic mutation resulting in a progressive disease of severe mental retardation and epilepsy beginning at infancy. The research was just published in the American Journal of Human Genetics.

13 Oct 2010

BIOBASE introduces Genome Trax Next Generation Sequencing solution

BIOBASE announced today that it is entering the Next Generation Sequencing (NGS) market with the launch of a new solution. Genome Trax™ enables researchers to identify genome variations of functional significance by mapping them to known elements such as gene regulatory sites and disease-linked mutations.

13 Oct 2010

Scientists identify mutant protein in type 2 diabetes

University of Michigan scientists have identified events inside insulin-producing pancreatic cells that set the stage for a neonatal form of non-autoimmune type 1 diabetes, and may play a role in type 2 diabetes as well. The results point to a potential target for drugs to protect normally functioning proteins essential for producing insulin.

13 Oct 2010

AACR announces recipients of Outstanding Investigator Award for Breast Cancer Research

The 33rd Annual CTRC-AACR San Antonio Breast Cancer Symposium will honor two leading breast cancer researchers during its meeting, which will be held Dec. 8-12 in the Henry B. Gonzales Convention Center, San Antonio, Texas. Klaus Pantel, M.D., Ph.D., is the recipient of the 2010 AACR Outstanding Investigator Award for Breast Cancer Research, funded by Susan G. Komen for the Cure.

12 Oct 2010

New targeted therapy adds benefit to erlotinib in some patients with advanced lung cancer

A subset of lung cancer patients seem to live longer and experience delays in disease progression when a new drug that targets a cancer-associated molecule called MET is added to treatment with erlotinib, the results of a double-blind Phase-II trial show.

11 Oct 2010

Erlotinib improves progression-free survival as first-line therapy in advanced lung cancer

For patients with advanced lung cancer whose tumors carry EGFR activating mutations, first-line treatment with erlotinib nearly tripled progression-free survival compared to a standard chemotherapy combination, show results from the first prospective Phase-III study to report findings in this setting.

11 Oct 2010

New phase 2 study shows first-line promise of lung cancer drug PF-299

A new-generation lung cancer drug has shown an impressive ability to prevent disease progression when administered as a first-line treatment in patients with advanced disease, investigators reported at the 35th Congress of the European Society for Medical Oncology (ESMO).

11 Oct 2010

Mutation News and Research

Vertex commences VX-770 and VX-809 combination Phase 2a clinical trial for cystic fibrosis

Metabolon announces publication of metabolic analysis of biochemical changes in CF primary lung epithelial cells

Cempra to present data on solithromycin, TAKSTA at 48th Annual Meeting in Vancouver

PTC announces ataluren Phase 2b efficacy data at International Congress

Novel approach to automated detection of bacterial pathogens in food

Discovery Labs to present lucinactant Phase 2a clinical study results at NACFC Conference

New development of genetic tool to speed discovery of novel genes involved in cancer

Journal of Clinical Oncology publishes IPI-504 Phase 2 study results

ARTS protein increases apoptosis mechanism to balance stem cells' regenerative power: Research

Study finds multiple genetic variations can contribute to common childhood obesity

Scientists identify root cause of chromosomal errors and gene diversity

Research may pave way to cure cystic fibrosis

Cancer Research UK launches programme to turn genetic revolution into better treatment for cancer patients

Defect in 21st amino acid leads to progressive brain atrophy: Study

BIOBASE introduces Genome Trax Next Generation Sequencing solution

Scientists identify mutant protein in type 2 diabetes

AACR announces recipients of Outstanding Investigator Award for Breast Cancer Research

New targeted therapy adds benefit to erlotinib in some patients with advanced lung cancer

Erlotinib improves progression-free survival as first-line therapy in advanced lung cancer

New phase 2 study shows first-line promise of lung cancer drug PF-299

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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