Myeloid Leukemia News and Research

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Myeloid Leukemia is an aggressive (fast-growing) disease in which too many myeloblasts (immature white blood cells that are not lymphoblasts) are found in the bone marrow and blood. Also called acute myeloblastic leukemia, acute myelogenous leukemia, acute nonlymphocytic leukemia, AML, and ANLL.

Future directions and challenges in harnessing NK cells against Acute Myeloid Leukemia

Acute Myeloid Leukemia (AML) remains one of the most challenging hematological malignancies to treat, with relapse and refractory cases continuing to pose significant hurdles

1 Oct 2024

Why children with Down’s syndrome are predisposed to developing leukaemia

The study uncovers mechanisms linking Down syndrome to leukemia, emphasizing the role of oxidative stress and genetic alterations in fetal blood development.

26 Sep 2024

New drug combo shows promise for deeper remission in chronic leukemia

Researchers leading the SWOG S1712 clinical trial have found that adding ruxolitinib to standard tyrosine kinase inhibitor (TKI) treatment for patients with chronic-phase chronic myeloid leukemia (CP-CML) significantly increased the percentage of patients who had a molecular response deep enough to warrant discontinuing treatment.

24 Sep 2024

Innovative triplet therapy shows encouraging results in advanced chronic myeloid leukemia

According to researchers at The University of Texas MD Anderson Cancer Center, 80% of patients with previously untreated or relapsed/refractory advanced-phase chronic myeloid leukemia (CML) – including both accelerated or myeloid blast phases of the disease – or Philadelphia chromosome-positive acute myeloid leukemia (AML) achieved a bone marrow remission when treated with a novel combination of decitabine, venetoclax and ponatinib.

17 Sep 2024

Study shows CAR T-cell therapy's risk of second primary malignancies comparable to other treatments

The frequency of second primary malignancies (SPMs) arising in cancer survivors following treatment with CAR T-cell therapy was statistically comparable to the frequency of SPMs following other standard-of-care therapies, according to a systematic review and meta-analysis.

11 Sep 2024

$1.2 million NIH grant may help unravel the interplay between Down syndrome and myeloid leukemia

A four-year, $1.2 million grant from the National Cancer Institute of the National Institutes of Health may help researchers find new clues to the interplay between Down syndrome (DS) and myeloid leukemia (ML).

11 Sep 2024

UC's Eric Vick receives major grants to advance research into combination therapy for leukemia

The University of Cincinnati Cancer Center's Eric Vick, MD, PhD, has been awarded a nearly $215,000 Career Development Award from the Leukemia and Lymphoma Society (LLS) and a $50,000 American Society of Clinical Oncology (ASCO) Young Investigator Award to continue research into a combination therapy treatment for acute myeloid leukemia (AML).

6 Sep 2024

Investigating inflammatory memory in hematopoietic stem cells within the AML niche

A new research perspective was published in Oncotarget's Volume 15 on September 4, 2024, entitled, "Trained and ready - the case for an inflammatory memory for hematopoietic stem and progenitor cells in the AML niche."

5 Sep 2024

Leukemia cells depend on P-bodies for growth and survival

An international team of scientists has uncovered a mechanism by which acute myeloid leukemia (AML) cells sustain their growth.

21 Aug 2024

Breakthrough in acute myeloid leukemia treatment targets stem cells

Acute myeloid leukemia is one of the deadliest cancers. Leukemic stem cells responsible for the disease are highly resistant to treatment.

24 Jul 2024

DDX41: A unique player in myeloid leukemogenesis

A new editorial paper was published in Oncotarget's Volume 15 on July 2, 2024, entitled, "DDX41 and its unique contribution to myeloid leukemogenesis."

19 Jul 2024

$Novel therapy can improve the prognosis of relapsed/refractory acute myeloid leukemia$

Novel therapy can improve the prognosis of relapsed/refractory acute myeloid leukemia

Relapsed/refractory acute myeloid leukemia (AML), a so-called blood cancer, has an extremely poor prognosis because of resistance to anti-cancer drugs and frailty of the patient's organ functions.

18 Jul 2024

Targeted gene therapy may reduce AML burden and protect the heart from cardiotoxicity

Researchers from the University of Missouri School of Medicine found that a targeted gene therapy may make acute myeloid leukemia (AML) more sensitive to chemotherapy, while also protecting the heart against toxicity often caused by cancer treatments.

27 Jun 2024

Myeloid Leukemia News and Research

Future directions and challenges in harnessing NK cells against Acute Myeloid Leukemia

Why children with Down’s syndrome are predisposed to developing leukaemia

New drug combo shows promise for deeper remission in chronic leukemia

Innovative triplet therapy shows encouraging results in advanced chronic myeloid leukemia

Study shows CAR T-cell therapy's risk of second primary malignancies comparable to other treatments

$1.2 million NIH grant may help unravel the interplay between Down syndrome and myeloid leukemia

UC's Eric Vick receives major grants to advance research into combination therapy for leukemia

Investigating inflammatory memory in hematopoietic stem cells within the AML niche

Leukemia cells depend on P-bodies for growth and survival

Breakthrough in acute myeloid leukemia treatment targets stem cells

DDX41: A unique player in myeloid leukemogenesis

Novel therapy can improve the prognosis of relapsed/refractory acute myeloid leukemia

Targeted gene therapy may reduce AML burden and protect the heart from cardiotoxicity

Artificial variants of Withanolides act highly specifically against leukemia cells

Metformin use linked to reduced risk of myeloproliferative neoplasms

AML patients at the extremes of older age derive benefit from VEN-HMA regimen

Medically aided conception vs. natural conception: Study explores cancer risk in children

Novel vaccine approach targets AML and other blood cancers

Urine-based test developed for early detection of head and neck tumors

NCCN 2024 Annual Conference focuses on practical applications for improving cancer care

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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