Neuropathy News and Research

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Research shows how loss of de-N-glycosylation enzyme causes detrimental effects

Peptide: N-glycanase (NGLY1) is an evolutionarily conserved enzyme for removing N-linked glycans (N-glycans) from glycoproteins and is involved in proteostasis of N-glycoproteins in the cytosol. In 2012, a rare genetic disorder called NGLY1 deficiency was discovered by an exome analysis.

7 Jul 2021

Are women more likely to develop long COVID?

Researchers found different groups of symptoms persisting after coronavirus disease 2019 (COVID-19), with fatigue and higher IL-6 levels common in women. About 75% of the patients they treated were women, indicating a link between sex hormones and immune response.

8 Jun 2021

Researchers discover a new and unique form of ALS

In a study of 11 medical-mystery patients, an international team of researchers led by scientists at the National Institutes of Health and the Uniformed Services University discovered a new and unique form of amyotrophic lateral sclerosis (ALS).

31 May 2021

Diabetes-prevention program supports the addition of quality-adjusted life-years to average lifespan

You can do a lot in four years: go from white to black belt in taekwondo, plant a dwarf apple tree and pick its fruit, see your grandchild off to college and attend her graduation or get your own degree.

18 May 2021

New peptide could allow cannabis to fight pain without side effects

Many people live with chronic pain, and in some cases, cannabis can provide relief. But the drug also can significantly impact memory and other cognitive functions.

12 May 2021

Normalizing cholesterol metabolism in microglia alleviates chronic neuropathic pain

Chemotherapy can induce a painful peripheral neuropathy (CIPN), a chronic condition and common adverse effect for cancer patients undergoing treatment.

10 May 2021

Novel CBD analog alleviates pain in mouse model of chemotherapy-induced peripheral neuropathy

For patients with chronic pain, ineffective treatments, lowered work productivity, and other factors often coalesce, fueling feelings of hopelessness and anxiety and setting the stage for even bigger problems, including substance use disorders.

5 May 2021

Study provides new insights into how signal molecules are transported in the axons

In a new study, researchers from the University of Copenhagen have gained new insights into how signal molecules are transported in some of the longest cells in the nervous system.

17 Apr 2021

FDA approves immunotherapy for first-line treatment of advanced gastric cancer

Today, the U.S. Food and Drug Administration approved Opdivo (nivolumab), in combination with certain types of chemotherapy, for the initial treatment of patients with advanced or metastatic gastric cancer, gastroesophageal junction cancer and esophageal adenocarcinoma.

16 Apr 2021

Targeted therapy achieves excellent outcomes, reduces side effects in high-risk Hodgkin lymphoma

Scientists are reporting results of the first frontline clinical trial to use targeted therapy to treat high-risk pediatric Hodgkin lymphoma.

8 Apr 2021

Can COVID-19 cause hearing loss, vertigo, and tinnitus?

Researchers at the University of Manchester, UK, aimed to systematically review the literature to provide evidence on SARS-CoV-2 and audio-vestibular symptoms. They found that COVID-19 has been tied to hearing loss, vertigo, and tinnitus.

26 Mar 2021

UTHSC professor awarded $1.79 million grant to develop new amyloidosis treatment

The National Institute of Diabetes and Digestive and Kidney Diseases recently awarded Jonathan Wall, PhD, professor in the University of Tennessee Health Science Center's Graduate School of Medicine in Knoxville, a $1.79 million grant for his study titled "Developing a Theranostic Immunotherapy for Systemic Amyloidosis."

16 Mar 2021

An increase in the risk of clinical sequelae after SARS-CoV-2 infection

A new piece of research, published on the medRxiv preprint server, focused on the role of factors such as gender, age, hospitalization, etc., in understanding the risks of clinical sequelae in the post-acute phase of COVID-19, in adults aged between 18 and 65 years.

15 Mar 2021

Discovery may help cancer patients to avoid chemotherapy's debilitating side effects

A discovery by University of Queensland pain researchers may allow some future cancer patients, including children with leukemia, to avoid their chemotherapy's worst and most debilitating side effects.

15 Mar 2021

Study reveals potential risk factors for developing nerve damage after cancer treatment

A low hemoglobin count, older age and high BMI are possible risk factors for developing nerve damage after cancer treatment, a UNSW-led study has found.

4 Mar 2021

Human brain adapts to loss of sensory information by tapping into visual cues

Evidence that a sense of our physical selves can develop even without the sense of touch has been uncovered in a new study by researchers in the UK and the United States.

18 Feb 2021

UC San Diego researchers launch clinical trial to test gene therapy for Alzheimer’s disease

Researchers at University of California San Diego School of Medicine have launched a first-in-human Phase I clinical trial to assess the safety and efficacy of a gene therapy to deliver a key protein into the brains of persons with Alzheimer's disease (AD) or Mild Cognitive Impairment (MCI), a condition that often precedes full-blown dementia.

18 Feb 2021

Study shows that physical embodiment can occur without sense of touch

Researchers at the University of Chicago, the University of Birmingham, and Bournemouth University have uncovered evidence that physical embodiment can occur without the sense of touch, thanks to a study involving two participants who lack the ability to feel touch. The research was published on Feb. 12 in Experimental Brain Research.

17 Feb 2021

How SARS-CoV-2 enters the central nervous system

The central nervous system (CNS) is highly protected in the human body. Yet, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades the CNS, causing profound clinical complications. How is the CNS involved in a respiratory virus infection?

15 Feb 2021

New review supports stricter control of HbA1C levels among children with type 1 diabetes

Diabetes is characterized by elevated levels of sugar or glucose (hyperglycemia) in the blood. This occurs due to the lack of the hormone insulin in type 1 diabetes, and to reduced insulin levels in combination with insulin resistance in type 2 diabetes.

15 Jan 2021