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New combination treatment authorized for unresectable urothelial cancer patients

Astellas Pharma Ltd. today announced that the Medicines and Healthcare products Regulatory Agency (MHRA) has granted authorization for PADCEV™ (enfortumab vedotin, an antibody-drug conjugate [ADC]) in combination with KEYTRUDA® (pembrolizumab, a PD-1 inhibitor) for the first-line treatment of adult patients with unresectable or metastatic urothelial cancer, who are eligible for platinum-containing chemotherapy.

18 Oct 2024

New study reveals two-thirds of diabetic men suffer from erectile dysfunction

Erectile dysfunction (ED) affects up to 66% of diabetic men globally, with risk factors like age, long-term diabetes, and obesity playing a significant role. The study emphasizes the urgent need for early diagnosis and effective diabetes management to reduce the burden of ED

17 Oct 2024

Innovative approaches to lymphatic pain relief in breast cancer patients

Among the 7.8 million women with breast cancer worldwide, at least 33% to 44% are affected by lymphatic pain. Breast cancer survivors usually suffer lymphatic pain in the ipsilateral body or upper limb, and pharmacological approaches are not effective for lymphatic pain.

12 Oct 2024

Fluorescein angiography improves diagnostic accuracy in carpal tunnel surgery

In modern office life, avoiding the onset of carpal tunnel syndrome might be a daily struggle. The worst case could mean needing surgery to alleviate compression of the nerves or to repair damaged nerves.

10 Oct 2024

Study paves way to more efficient non-addictive treatment for chronic pain

Researchers at Karolinska Institutet in Sweden have developed a new comprehensive mapping of genetic activity for understanding the causes of chronic pain.

4 Oct 2024

Research heralds in a new era for genetic sequencing and testing

Research led by scientists at Queen Mary University of London is heralding in a new era for genetic sequencing and testing.

1 Oct 2024

Intensive diabetes treatment improves periodontal health

While the link between diabetes and periodontal disease is known, the impact of diabetes treatment on periodontal health is less well understood.

17 Sep 2024

Telisotuzumab vedotin shows promising results in asian patients with c-Met overexpressing NSCLC

The c-Met-directed antibody-drug conjugate telisotuzumab vedotin demonstrated durable responses and an acceptable safety profile in patients of Asian race with c-Met protein-overexpressing, epidermal growth factor receptor (EGFR) wildtype (WT), locally advanced/metastatic nonsquamous non-small cell lung cancer (NSCLC), according to research presented today at the International Association for the Study of Lung Cancer's 2024 World Conference on Lung Cancer.

11 Sep 2024

Study finds higher risk of gum disease in diabetics with microvascular complications

Gum disease is more common in individuals with microvascular complications of diabetes, new research being presented at the annual meeting of the European Association for the Study of Diabetes (EASD) in Madrid, Spain (9-13 September) and published in The Journal of Dental Research has found.

10 Sep 2024

Reduced heart rate variability linked to higher mortality in people with diabetes

Disruption to normal variations in daily heart rate (HR) is associated with a much higher risk of dying in people with type 1 and type 2 diabetes over 21 years, according to new research to be presented at this year's Annual Meeting of The European Association for the Study of Diabetes (EASD), Madrid (9-13 Sept).

9 Sep 2024

Tirzepatide beats semaglutide in lowering diabetes risk and cardiovascular events in obesity patients

A study published in eClinicalMedicine found that tirzepatide outperforms semaglutide in reducing the risk of type 2 diabetes and major cardiovascular events among individuals with obesity, with or without existing diabetes, while also achieving greater weight loss.

28 Aug 2024

SCARB2 deficiency disrupts bile acid metabolism and gut microbiome

The study details the connection between SCARB2 deficiency and gastrointestinal dysfunction, revealing that the loss of SCARB2 leads to alterations in bile acid metabolism and dysbiosis in the gut microbiome. This disruption affects the signaling pathway involving FXR, which normally regulates bile acid synthesis and intestinal lipid absorption. The hyperactive FXR in Scarb2-deficient mice leads to a decrease in epithelial cell turnover and lipid malabsorption, particularly impacting the absorption of vitamin E, which is crucial for maintaining neurological health. The researchers further explored the impact of these changes on the gut-liver axis and found alterations in the expression of genes related to bile acid synthesis.

23 Aug 2024

Stretching vs. meditation: New study finds both practices reduce nocturnal muscle cramps in cirrhosis patients

Researchers investigate the effects of stretching and meditation on nocturnal muscle cramps in patients with cirrhosis.

15 Aug 2024

$Poor physical function, not bone density, drives higher fracture risk in older women with type 2 diabetes$

Poor physical function, not bone density, drives higher fracture risk in older women with type 2 diabetes

Study indicates that older women with type 2 diabetes have a higher risk of fractures primarily due to impaired physical function rather than reduced bone density, despite stronger bone structure.

8 Aug 2024

Does type 1 diabetes affect taste and flavor recognition?

Type 1 diabetes patients show reduced taste and flavor perception, affecting food preferences and quality of life. This highlights the need for further research into the sensory changes in T1D.

7 Aug 2024

Xanthones show promise in diabetes with antioxidant and anti-inflammatory properties

Research reveals xanthones as promising agents in diabetes management, offering antioxidant, anti-inflammatory, and insulin-sensitizing benefits.

29 Jul 2024

Increased cannabis use in diabetics raises concerns about health risks

Researchers at University of California San Diego School of Medicine have found a significant increase in cannabis use among adults with diabetes in the United States, raising concerns about the potential impact on their health outcomes. The new study, which analyzed nationally representative data from the 2021-2022 National Survey on Drug Use and Health (NSDUH), estimated that 9.0 percent of adults with diabetes used cannabis in the past month, with a 33.7 percent increase in prevalence-;from 7.7 percent to 10.3 percent-;between 2021 and 2022.

23 Jul 2024