Nucleoside News and Research

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NIH animal study combines Paxlovid with Lagevrio against SARS-CoV-2 Delta

In a recent study posted to the bioRxiv* preprint server, researchers at the U.S National Institutes of Health demonstrated the efficacy of molnupiravir and nirmatrelvir, two oral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antivirals in the rhesus macaque model, the closest proxy to humans.

7 Sep 2022

Molecular fate-mapping of antibodies shows effects of antigenic imprinting

In a new study, researchers developed a molecular fate-mapping method for differential detection of antibodies derived from specific B cell clones.

1 Sep 2022

Discovery may lead to the development of new systems of antifungal drugs

Mycosis is an infectious disease caused by parasitic mold or yeast and treated with an antifungal, a subgroup of antibiotics.

26 Aug 2022

Remdesivir activates urotensin II receptor and induces cardiomyocyte dysfunction

In newly released research, scientists assessed the cardiac effects of remdesivir.

12 Aug 2022

Rice University researchers model a key mechanism by which DNA replicates

Knowing the structure of a complex biological system isn't nearly enough to understand how it works. It helps to know how the system moves.

10 Aug 2022

Is cannabidiol effective against COVID-19?

A new study discusses the utility of CBD in treating the inflammatory symptoms of COVID-19

31 Jul 2022

Remdesivir resistance in renal transplant patients with long COVID-19

A new study has reported two renal transplant cases, in which individuals, after being exposed to remdesivir, developed a resistance to the drug.

1 Jul 2022

SARS-CoV-2 mRNA vaccines do not stimulate interferon stimulatory gene expression in Aicardi Goutières Syndrome patients

A new study aimed to evaluate the immunostimulatory potential of mRNA vaccines in AGS patients.

23 May 2022

Study demonstrates that ATV006 is orally bioavailable and has potent efficacy against SARS-CoV-2

A new study has revealed that ATV006, which is a 5′-hydroxyl-isobutyryl prodrug, possesses extraordinary oral pharmaco-kinetic (PK) profiles in rats and cynomolgus monkeys and exhibited significant antiviral activity against ancestral SARS-COV-2 strain as well as VOCs.

20 May 2022

sCPD9: a SARS-CoV-2 nasal vaccine candidate that may have superior efficacy

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19 May 2022

Marine bioactive compounds against SARS-CoV-2

A new review paper published in the journal Environmental Science and Pollution Research aimed to determine the possibilities of using biologically active compounds derived from various chemical classes of marine organisms against SARS-CoV-2 infection at various stages of the life cycle of the virus.

6 May 2022

SARS-CoV-2 develops partial resistance to the antiviral drug remdesivir in cell culture

The virus that causes COVID-19 can develop partial resistance to the antiviral drug remdesivir during infection of cultured cells in the laboratory by more than one mechanism.

5 May 2022

Artificial circular RNAs found to bypass cellular antiviral responses

Researchers produced artificial circular ribonucleic acid sponges in a permuted intron-exon system and showed that these did not activate innate immunity.

29 Apr 2022

Antibody response to Pfizer-BioNTech COVID-19 vaccine over 6 months

A new study published in PLoS ONE characterizes the antibody response to BNT162b2, the Pfizer-BioNTech COVID-19 vaccine

20 Apr 2022

Oral version of remdesivir could extend its reach and benefits to COVID-19 patients

Scientists at the University of North Carolina at Chapel Hill are testing a new route for remdesivir, a pill form of the COVID-19 treatment that’s given to half of all hospitalized patients with the disease.

22 Mar 2022

Innate and adaptive immune responses to BNT162b2 vaccination in mice

Researchers analyzed the innate and adaptive responses to the mRNA-based BNT162b2 COVID-19 vaccine in mice.

18 Mar 2022

Exploring biomedical literature and clinical trial records to identify new drug combinations for COVID-19 treatment

Researchers extensively searched publicly available SARS-CoV-2 biomedical literature to identify drug combinations that could effectively treat COVID-19.

7 Mar 2022

Combating COVID cytokine storm with targeted nucleic acid therapies

Researchers examine current nucleic acid-based treatments against COVID-19 and their methods of action.

6 Mar 2022

Adenosine receptor agonists provide therapeutic target in mouse SARS-CoV-2 infection

A new study describes the efficacy of adenosine receptor agonists in the treatment of SARS-CoV-2 infection.

2 Mar 2022

Study finds MK-4482 inhibits replication of multiple SARS-CoV-2 variants of concern in Syrian hamster COVID-19 model

Researchers found that an antiviral drug, was effective against SARS-CoV-2 variants, including the recently emerged Omicron variant, in Syrian hamsters.

1 Mar 2022