Oligonucleotides News and Research

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Oligonucleotides are short sequences of nucleotides (RNA or DNA), typically with twenty or fewer bases. Automated synthesizers allow the synthesis of oligonucleotides up to 160 to 200 bases.
Polyuridine sequence of mouse coronavirus can be targeted to prevent host cell death

Polyuridine sequence of mouse coronavirus can be targeted to prevent host cell death

Could novel biosensors facilitate SARS-CoV-2 antiviral drug research?

Could novel biosensors facilitate SARS-CoV-2 antiviral drug research?

SARS-CoV-2 interacts with unusual RNA structures in human cells

SARS-CoV-2 interacts with unusual RNA structures in human cells

Neutralizing aptamers block SARS-CoV-2 infection in vitro

Neutralizing aptamers block SARS-CoV-2 infection in vitro

Uncovering cellular mechanism related to gene silencing therapies

Uncovering cellular mechanism related to gene silencing therapies

New components for oligonucleotide drugs show safety, efficacy in treating spinal muscular atrophy

New components for oligonucleotide drugs show safety, efficacy in treating spinal muscular atrophy

SARS-CoV-2 test in 20 minutes with FISH

SARS-CoV-2 test in 20 minutes with FISH

Viral phosphoesterases (including in CoVs) can restrict antiviral innate immunity

Viral phosphoesterases (including in CoVs) can restrict antiviral innate immunity

Study reveals potentially druggable process of SARS-Cov-2 assembly and replication

Study reveals potentially druggable process of SARS-Cov-2 assembly and replication

Researchers demonstrate a potentially powerful strategy for treating cystic fibrosis

Researchers demonstrate a potentially powerful strategy for treating cystic fibrosis

What makes the elderly more susceptible to SARS-CoV-2 infection?

What makes the elderly more susceptible to SARS-CoV-2 infection?

Researchers identify a common mechanism underlying diverse brain disorders

Researchers identify a common mechanism underlying diverse brain disorders

Synthetic microRNA can serve as a novel therapeutic agent for treating human cancer

Synthetic microRNA can serve as a novel therapeutic agent for treating human cancer

NUS researchers develop a way to automate the production of pharmaceutical small molecules

NUS researchers develop a way to automate the production of pharmaceutical small molecules

Intranasal COVID-19 therapeutic shows promise in preclinical trials

Intranasal COVID-19 therapeutic shows promise in preclinical trials

A new method for efficient and automated production of synthetic DNA

A new method for efficient and automated production of synthetic DNA

Brain-targeting drug delivery with nano-scaled apoptotic bodies

Brain-targeting drug delivery with nano-scaled apoptotic bodies

New efforts to improve the efficacy of nucleotide-based drugs against prostate cancer, bone metastasis

New efforts to improve the efficacy of nucleotide-based drugs against prostate cancer, bone metastasis

Novel mRNA delivery vehicle provides alternative to LNPs for SARS-CoV-2 vaccines

Novel mRNA delivery vehicle provides alternative to LNPs for SARS-CoV-2 vaccines

Single injection of RNA therapy improves vision in patient with genetic form of childhood blindness

Single injection of RNA therapy improves vision in patient with genetic form of childhood blindness

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