Oncogenesis News and Research

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Breakthrough study reveals melanoma's resistance tactics to targeted therapy

Melanoma is the deadliest form of skin cancer. With global incidence rates rising, new, more effective treatments are necessary to alleviate the health burden of the disease. Important advances in recent years include doctors using genetic tests to look for specific mutations they can target for more personalised, effective treatment.

13 Apr 2024

New protein-based micromaterials developed for targeted cancer therapy

Researchers at the Universitat Autònoma de Barcelona (UAB), in collaboration with the Sant Pau Research Institute and the CIBER-BBN, have developed micromaterials made up only of proteins, capable of delivering over an extended period of time nanoparticles that attack specific cancer cells and destroy them.

5 Apr 2024

Breakthrough in CRISPR delivery promises safer gene editing

Recent research in PNAS highlights advancements in non-viral, cell-specific delivery methods for CRISPR-Cas systems, emphasizing their potential to enhance research and gene therapy applications by minimizing risks associated with off-target effects and improving targeted delivery.

7 Mar 2024

Does vitamin D have protective role against COVID-19?

Whether vitamin D supplementation before the onset of COVID-19 could provide benefits.

1 Mar 2024

Midbody remnant found to play role in cancer spread

Once thought to be the trash can of the cell, a little bubble of cellular stuff called the midbody remnant is actually packing working genetic material with the power to change the fate of other cells -; including turning them into cancer.

9 Oct 2023

Research demonstrates a double-acting mechanism for fighting triple-negative breast cancer

Zachary Schug, Ph.D., assistant professor in the Molecular and Cellular Oncogenesis Program of the Ellen and Ronald Caplan Cancer Center at The Wistar Institute, has published a new paper in the journal Nature Cancer.

19 Sep 2023

Effect of mutations in cancer-driving genes across human cancers

Effect of mutations in cancer-driving genes across human cancers.

9 Aug 2023

Senolysis holds great promise for developing new therapeutics for cancers and age-related diseases

Announcing a new publication for Acta Materia Medica journal. The prevalence of age-related diseases has been progressively increasing worldwide.

24 Jul 2023

Study reveals molecular mechanisms of H. pylori-induced gastric carcinogenesis

Helicobacter pylori (H. pylori) infections are commonly associated with abdominal pain, bloating, and acidity. Clinical evidence suggests that infection with H. pylori cagA+ strains dramatically increases the risk of developing gastric cancer.

18 Jul 2023

Mutations in AGC kinase motif linked to colorectal cancer growth

Cancer spreads throughout the human body in cunning, almost militaristic, ways. For example, it can manipulate our genetic make-up, take over specific cell-to-cell signaling processes, and mutate key enzymes to promote tumor growth, resist therapies, and hasten its spread from the original site to the bloodstream or other organs.

3 Jul 2023

Study shows impacts of ASO-based MALAT1-inhibition on MAPK-pathway gene regulation in melanoma

A new research paper was published in Oncotarget's Volume 14 on May 26, 2023, entitled, "Deconstructing the role of MALAT1 in MAPK-signaling in melanoma: insights from antisense oligonucleotide treatment."

30 May 2023

Identify the underlying mechanism associated with the initiation of focal amplification in breast cancer

Identifying the underlying mechanism associated with the initiation of focal amplification in breast cancer.

19 May 2023

Wistar scientists uncover a key mechanism as to how p53 suppresses tumors

The p53 gene is one of the most important in the human genome: the only role of the p53 protein that this gene encodes is to sense when a tumor is forming and to kill it.

5 May 2023

Advancements in understanding and treating breast cancer

Researchers describe recent advancements in breast cancer research.

26 Mar 2023

Newly identified gene signature helps assess cancer risk and optimize treatment

In a paper published in PNAS, Maureen Murphy, Ph.D., Deputy Director of Wistar's Ellen and Ronald Caplan Cancer Center and Ira Brind Professor and Program Leader in the Molecular & Cellular Oncogenesis Program, and team have identified a gene signature that accurately predicts the functioning of P53 variants, important information to assessing cancer risk and optimizing choices for cancer therapeutics.

7 Feb 2023

New research extensively explores 12 distinctive aging traits

In a recent article published in Cell, researchers proposed that 12 distinctive traits of aging are all inter-related.

5 Jan 2023

Human fetal cerebellar cell atlas reveals the origin of aggressive medulloblastomas

Studying mice has filled encyclopedias with breakthrough medical discoveries. But when it comes to brain cancers, the little rodents have long exhibited fundamental limitations.

30 Nov 2022

Over 440 SCI articles published! BGI’s cancer genetics and cell research fuels innovation

BGI has currently published over 440 SCI (Science Citation Index) papers in the field of cancer research, with a cumulative impact factor of over 4,000 points.

From BGI Genomics 23 Nov 2022

Fungi detected in 35 cancer types, often intracellular

In a recent article published in the journal Cell, researchers found fungal deoxyribonucleic acid (DNA) and cells at low abundances across many human cancers, with cancer type-dependent variations in fungus community composition and fungal-bacteriome interactions.

22 Nov 2022

Research uncovers novel predictors of immune checkpoint inhibitor therapy for melanoma

Immune checkpoint inhibitor (ICI) therapy is a type of treatment for melanoma, the deadliest form of skin cancer, which blocks proteins on tumor or immune cells that prevent the immune system from killing cancer cells.

19 Sep 2022