Opioids News and Research

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An opioid is a chemical that works by binding to opioid receptors, which are found principally in the central nervous system and the gastrointestinal tract. The receptors in these two organ systems mediate both the beneficial effects and the side effects of opioids.

FDA panel favors continued research on novel pain medicine

A panel of experts for the U.S. Food and Drugs Administration (FDA) this Monday recommended that the federal government should allow continued testing of an experimental class of pain drugs for arthritis, despite links to bone decay and joint failure.

13 Mar 2012

Veterans prescribed more opioid pain killers: Study

According to a new government study Morphine and similar powerful painkillers are sometimes prescribed to recent war veterans suffering from post-traumatic stress along with physical pain. The study suggests that these vets are at high risk for drug and alcohol abuse, but they're two times more likely to get prescriptions for addictive painkillers than vets with only physical pain.

7 Mar 2012

Methylnaltrexone may restore bowel function in critically ill patients

Opioids are a mainstay of care in the critical care unit, but their use frequently causes constipation which can lead to adverse outcomes including delayed feeding and later discharge from the ICU. Researchers from London, UK, and Chicago, IL, have found that methylnaltrexone (MNTX), a peripheral opioid antagonist, may restore bowel function in critically ill patients.

2 Mar 2012

New NPS information on dextropropoxyphene: recommendations and alternatives

NPS has published information online for prescribers to help them prepare for the TGA’s cancellation of Capadex and Paradex, two of the four medicines available in Australia containing dextropropoxyphene.

1 Mar 2012

Report identifies patterns in misuse of illicit and prescription drugs among young adults

A new report from researchers at the Drexel University School of Public Health identifies patterns in the misuse of illicit drugs among young adults who also misuse prescription drugs.

28 Feb 2012

JAM study highlights emerging problem in addiction therapy

A Journal of Addiction Medicine (JAM) study was cited in a recent Center for Substance Abuse Research (CESAR) series highlighting an emerging problem in addiction therapy: the diversion and misuse of the medication buprenorphine.

28 Feb 2012

Chronic pain patients at high-risk for comorbid substance abuse benefit from 3-week program

Research presented at the American Academy of Pain Medicine's 28th Annual Meeting shows that substance use education incorporated into a cognitive behavioral rehabilitation programming is effective to improve pain and function for the chronic pain patient at high-risk for comorbid substance abuse.

27 Feb 2012

Endo fourth quarter total revenues increase 57% to $803.4 million

Endo Pharmaceuticals today reported financial results for the fourth quarter of 2011.

24 Feb 2012

OGF-OGFr axis discovery provides new insights into ovarian cancer

Researchers at The Pennsylvania State University College of Medicine, Hershey, Pennsylvania have discovered that the presence and integrity of the opioid growth factor receptor (OGFr), which mediates the inhibitory action of opioid growth factor (OGF) on cell proliferation, is a key to understanding the progression and treatment of human ovarian cancer.

22 Feb 2012

Modified imatinib cancer drug prevents morphine tolerance in rats

By reformulating the common cancer drug imatinib (Gleevec), researchers have eliminated morphine tolerance in rats - an important step toward improving the effectiveness of chronic pain management in patients, according to researchers at The University of Texas MD Anderson Cancer Center.

20 Feb 2012

FSMB initiatives to raise awareness about opioid prescribing

The Federation of State Medical Boards (FSMB) announced today several initiatives aimed at addressing the rise of opioid abuse and related deaths in the United States, while safeguarding legitimate access to medications for patients with pain.

18 Feb 2012

Web-based intervention can effectively manage chronic migraine

painACTION.com is a free, non-promotional online program designed to support self-management and improve overall function in people with chronic pain. This study tested painACTION.com's ability to increase the use of self-management skills in people with chronic migraine headaches.

17 Feb 2012

Trevena commences TRV130 Phase I clinical trial for severe post-operative pain

Trevena, Inc., the leader in discovery and development of G-protein coupled receptor (GPCR) biased ligands, announced today the initiation of a Phase I clinical trial of TRV130, a novel candidate designed for the intravenous treatment of moderate-to-severe post-operative pain.

13 Feb 2012

Bupivacaine may effectively manage pain after total knee replacement

Researchers at the Rothman Institute at Jefferson have shown that local anesthesia delivered through a catheter in the joint, intraarticularly, may be more beneficial than traditional opioids such as morphine and Oxycontin for pain management following total knee replacement surgery.

10 Feb 2012

Comprehensive program to help reduce health risks of narcotics drugs on injured workers

Accident Fund Holdings, Inc. recently created a comprehensive narcotics program to help reduce the health risks of these drugs on injured workers and ultimately provide a mechanism for them to get back to work sooner.

6 Feb 2012

New editorial offers clarity on confusing drug and alcohol addiction terminology

A new editorial released this week offers clarity and structure on confusing drug and alcohol addiction terminology for prescribers, users and regulators. "Through a glass darkly: can we improve clarity about mechanism and aims of medications in drug and alcohol treatments?" is published in the Journal of Psychopharmacology, the official journal of the British Association for Psychopharmacology, published by SAGE.

4 Feb 2012

Takeda, SPI announce that lubiprostone phase 3 trial on OBD meets primary endpoint

Sucampo Pharmaceuticals, Inc. and Takeda Pharmaceuticals U.S.A., Inc. announced today that lubiprostone met the primary endpoint in a phase 3 clinical trial for the treatment of opioid-induced bowel dysfunction (OBD) in patients with chronic, non-cancer pain, excluding those taking methadone.

2 Feb 2012

Array second quarter revenue increases to $23.2 million

Array BioPharma Inc. today reported financial results for the second quarter of fiscal 2012.

31 Jan 2012

Research on neuron interaction could lead to potential treatment for addiction

Harvard scientists have developed the fullest picture yet of how neurons in the brain interact to reinforce behaviors ranging from learning to drug use, a finding that might open the door to possible breakthroughs in the treatment of addiction.

19 Jan 2012

Heavy drinking may reinforce itself by stimulating endorphin release: Study

A new study has shown that drinking alcohol causes a pleasant feeling because it releases endorphins, the brain’s natural opioids. It adds that problem drinkers differ from social drinkers in the way alcohol affects one part of the brain. The report appeared Wednesday in Science Translational Medicine.

15 Jan 2012